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Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies

Molecules(2025)10.3390/molecules30102171Source: DataRank Database

Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies is a research paper published in Molecules (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Enrichment:Funding (2 grants)OA: goldTopics (29)IDs (PubMed, PMC)Annotations (1)

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Authors (6)

Maria Paola Giovannoni ORCID,Tengis S. Pavlov ORCID,Veniamin Ivanov ORCID,Fabrizio Melani,Gabriella Guerrini ORCID

Live enrichment

PubMed:40430343 PMC:PMC12114274

NIH

Grant: DK123266

National Institutes of Health

Grant: 5R01DK123266-04

Pannexin-1/P2X7 interaction promotes excessive ATP release in kidney cysts and ADPKD progression via reduced NaCl reabsorption

goldLicense: cc-by

publisherhttps://doi.org/10.3390/molecules30102171

publisherhttps://www.mdpi.com/1420-3049/30/10/2171/pdf

repositoryhttps://doaj.org/article/345ce0cecaca4eeabd84d1a1d1cd3c54

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12114274

Europe_PMChttps://europepmc.org/articles/PMC12114274

Fields of Study

01 natural sciences0104 chemical sciences

MeSH Terms

AnimalsHumansMefloquineQuinolonesConnexinsNerve Tissue ProteinsMolecular StructureStructure-Activity RelationshipMolecular Docking Simulation

Keywords

Patch clampMolecular dockingQUinolonesMultiple Linear Regression (Mlr)Panx1Channel BlockersPanx1; channel blockers; quinolones; patch clamp; molecular docking; multiple linear regression (MLR)Molecular StructureOrganic chemistryNerve Tissue ProteinsArticleConnexinsMefloquineMolecular Docking SimulationStructure-Activity RelationshipQD241-441HumansAnimals