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Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism

Pathogens(2024)10.3390/pathogens13100867Source: DataRank Database

Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism is a research paper published in Pathogens (2024). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (51)IDs (PubMed, PMC)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Samuel B. Anyona ORCID,Ivy Hurwitz ORCID,Evans Raballah ORCID,Sharely A. Wasena ORCID,Shamim W Osata ORCID

Live enrichment

PubMed:39452740 PMC:PMC11510049

National Institutes of Health (NIH)

Grant: R01AI130473

National Institutes of Health (NIH)

Grant: R01AI51305

National Institutes of Health (NIH)

Grant: R01AI051305

National Institutes of Health (NIH)

Grant: K43TW011581

National Institutes of Health (NIH)

Grant: D43TW05884

National Institutes of Health (NIH)

Grant: D43TW010543

National Institutes of Health (NIH)

Grant: 20150090DR

FIC NIH HHS

Grant: D43 TW005884

NIH HHS

Grant: 1C06TW058841-24S26

National Institutes of Health

Grant: 3D43TW010543-06S3

Partnership for Global Health Research Training Program(Renewal)

National Institutes of Health

Grant: 5D43TW005884-16

Training and Research on Severe Malarial Anemia

National Institutes of Health

Grant: 1K43TW011581-01

Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial Anemia

National Institutes of Health

Grant: 2R01AI130473-06A1

Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic Strategies

National Institutes of Health

Grant: 5R01AI051305-02

GENETIC BASIS OF SEVERE MALARIAL ANEMIA

goldLicense: cc-by

publisherhttps://www.mdpi.com/2076-0817/13/10/867/pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11510049/pdf/pathogens-13-00867.pdf

Europe_PMChttps://europepmc.org/articles/PMC11510049

Europe_PMChttps://europepmc.org/articles/PMC11510049?pdf=render

https://doi.org/10.3390/pathogens13100867

Fields of Study

03 medical and health sciences0303 health sciences

MeSH Terms

HumansPlasmodium falciparumMalaria, FalciparumAnemiaGlutamineChaperonin 60Mitochondrial ProteinsProteomicsSignal TransductionChildChild, PreschoolInfantKenyaFemaleMaleHSP70 Heat-Shock ProteinsToll-Like Receptor 2Toll-Like Receptor 4Transcriptome

Keywords

Heat shock proteinsGlutamine synthetaseProteomicsDifferential gene expressionToll-like receptorsRna-seqHost Immune ResponseGlutamine TransportersChildhood Innate ImmunityMaleGlutaminePlasmodium falciparumArticleMitochondrial ProteinsHumansHSP70 Heat-Shock ProteinsMalaria, FalciparumChildRInfantAnemiaChaperonin 60KenyaToll-Like Receptor 2Toll-Like Receptor 4Child, PreschoolMedicineFemaleTranscriptomeSignal Transduction