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GaugeFixer: overcoming parameter non-identifiability in models of sequence-function relationships

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.08.693054Source: DataRank Database

GaugeFixer: overcoming parameter non-identifiability in models of sequence-function relationships is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (20)IDs (PubMed, OpenAlex)

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Authors (3)

David M. McCandlish ORCID,Justin B. Kinney ORCID,Carlos Martí‐Gómez ORCID

Live enrichment

PubMed:41427346 OpenAlex:https://openalex.org/W4417200173

National Institutes of Health

Grant: R01HG011787

National Institutes of Health

Grant: R35GM133777

National Institutes of Health

Grant: R35GM133613

National Institutes of Health

Grant: S10OD028632

greenLicense: cc-by

repositoryhttps://doi.org/10.64898/2025.12.08.693054

publisherhttps://syndication.highwire.org/content/doi/10.64898/2025.12.08.693054

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41427346

repositoryhttps://repository.cshl.edu/id/eprint/42037/1/10.64898.2025.12.08.693054.pdf

Fields of Study

RNA and protein synthesis mechanismsEvolution and Genetic DynamicsGenomics and Phylogenetic Studies

Keywords

Mathematical modelQuadratic growthInterpretation (philosophy)Python (programming language)ExploitMathematical structureProjection (relational algebra)HeuristicsBridging (networking)EpistasisFitness landscapeGauge fixingGeneralized one-hot modelsKronecker productParameter non-identifiabilitySequence-function relationshipsShine-Dalgarno sequence