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Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling

10.64898/2025.12.12.694068Source: DataRank Database

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling is a research paper. On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)OA: greenTopics (13)IDs (PubMed, OpenAlex)

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Authors (5)

R.A.P. Padua ORCID,Adedolapo Ojoawo ORCID,Camille Sullivan ORCID,Dorothee Kern ORCID,Andrew Glaser ORCID

Live enrichment

PubMed:41415432 OpenAlex:https://openalex.org/W4417524484

NIGMS NIH HHS

Grant: P30 GM124169

NIGMS NIH HHS

Grant: P30 GM133894

NIGMS NIH HHS

Grant: R24 GM141526

NIH HHS

Grant: S10 OD021832

Howard Hughes Medical Institute

greenLicense: cc-by

repositoryhttps://doi.org/10.64898/2025.12.12.694068

publisherhttps://syndication.highwire.org/content/doi/10.64898/2025.12.12.694068

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41415432

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12710772/

Fields of Study

Protein Tyrosine PhosphatasesDiabetes and associated disordersProtein Kinase Regulation and GTPase Signaling

Keywords

PhosphopeptideProtein tyrosine phosphatasePhosphataseSH2 domainRegulatorMutationConformational changeConformational ensemblesSalt bridgeMolecular dynamics

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling

FAIR Checklist

Authors (5)

Funding (5 grants)

Open Access

Topics