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An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics

10.64898/2026.03.23.26349105Source: DataRank Database

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics is a research paper. On theSindex it has a DataRank of 0.181. It has been cited 2 times, with 2 citing works in its 1-hop citation network.

N/A

0.181DataRank · unranked

Scored on demand from live citation data

2 citations · 2 citing works in its network

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:OA: greenTopics (12)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

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DataRank Breakdown

Base Score 91%Citation Network 9%

Base Score Contribution

0.165

From this paper's citation signal

Citation Network Contribution

0.0159

From 1 citing papers with measurable signal

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Top 2 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 2 citers.

Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans
Frontiers in Genetics20263 citations74 referencesContributes 0.019
Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer’s Disease
bioRxiv (Cold Spring Harbor Laboratory)20260 citations73 referencesContributes 0.000

Authors (12)

Alina PS Pang,Ryan P. Coyle,Johannes Schlachetzki,Anthony J.A. Molina,Lane Bushman

Live enrichment

PubMed:41929344 OpenAlex:https://openalex.org/W7140556499

greenLicense: cc-by-nc-nd

repositoryhttps://doi.org/10.64898/2026.03.23.26349105

repositoryhttps://doi.org/10.64898/2026.03.23.26349105

publisherhttps://syndication.highwire.org/content/doi/10.64898/2026.03.23.26349105

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41929344

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13042090/

Fields of Study

HIV-related health complications and treatmentsEpigenetics and DNA MethylationHIV/AIDS drug development and treatment

Keywords

EpigeneticsDNA methylationRetrotransposonPharmacokineticsDosingBiological ageReverse transcriptasePharmacodynamicsHuman immunodeficiency virus (HIV)

Sustainable Development Goals

SDG 0: Good health and well-being