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PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

eLife(2020)10.7554/elife.52241Source: DataRank Database

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation is a research paper published in eLife (2020). On theSindex it has a DataRank of 1.2. It has been cited 34 times, with 29 citing works in its 1-hop citation network.

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1.2DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access34 citations · 29 citing works in its network

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doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE138692

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)OA: goldTopics (54)IDs (PubMed, PMC)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 45%Citation Network 55%

Base Score Contribution

0.533

From this paper's citation signal

Citation Network Contribution

0.641

From 24 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 29 citers.

Identification of potent and selective inhibitors of PKR via virtual screening and traditional design
Bioorganic & Medicinal Chemistry Letters202214 citations38 referencesContributes 0.071
dsRNA-induced condensation of antiviral proteins modulates PKR activity
Proceedings of the National Academy of Sciences202266 citations61 referencesContributes 0.069
Kinetics of osmotic stress regulate a cell fate switch of cell survival
Science Advances202137 citations53 referencesContributes 0.069
Polarity-Driven Fluorescence Monitoring of Lipid Droplet Dynamics in Dry Eye Disease
Analytical Chemistry202425 citations56 referencesContributes 0.058
PRKRA promotes pancreatic cancer progression by upregulating MMP1 transcription via the NF-κB pathway
Heliyon202312 citations52 referencesContributes 0.049

Authors (20)

Dawid Krokowski,Bo‐Jhih Guan,Zhaofeng Gao ORCID,Xing‐Huang Gao ORCID,Jing Wu ORCID

Live enrichment

PubMed:32175843 PMC:PMC7145421

National Institutes of Health

Grant: R01DK53307

National Institute of Allergy and Infectious Diseases

Grant: R01AI116730

National Science Centre

Grant: 2018/30/E/NZ1/00605

Cleveland Digestive Disease Research Core Center

Grant: DK097948

National Institutes of Health

Grant: R01DK060596

National Institutes of Health

Grant: R01DK113196

National Institute of Allergy and Infectious Diseases

Grant: R21AI144264

NCI NIH HHS

Grant: P01 CA062220

NIDDK NIH HHS

Grant: R01 DK053307

NIDDK NIH HHS

Grant: P30 DK097948

National Institutes of Health

Grant: 1R01DK060596-01

Translational Control by Nutrients

National Institutes of Health

Grant: 1R21AI144264-01

Regulation of B cell function and antibody class switching by c-Rel O-GlcNAcylation

National Institutes of Health

Grant: 5P30DK097948-05

The Cleveland Digestive Diseases Research Core Center (DDRCC)

National Institutes of Health

Grant: 5R01DK053307-09

Regulation of Cationic Amino Acid Transport by Stress.

National Institutes of Health

Grant: 5R01AI116730-02

Transcriptional regulation by O-GlcNAcylation in T lymphocytes

National Institutes of Health

Grant: 1R01DK113196-01A1

Sarcopenia in cirrhosis is mediated by a hyperammonemic stress response

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.52241

publisherhttps://cdn.elifesciences.org/articles/52241/elife-52241-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/52241/elife-52241-v2.xml

publisherhttps://elifesciences.org/articles/52241

repositoryhttps://doaj.org/article/bfbaa90f7d4c41fb9bf0e7ea7e264f23

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Cell LineAnimalsHumansMiceeIF-2 KinaseCarrier ProteinsRNA-Binding ProteinsNF-kappa BProto-Oncogene Proteins c-relAdaptation, PhysiologicalSignal TransductionGene Expression RegulationRNA InterferenceOsmotic Pressure

Keywords

GeneticsMouseInflammationGenomicsimmunologyTonebpPkrHyperosmotic StressNf-κb P65PactNf-κb C-rel570OsmoadaptationQH301-705.5Science610Cell LineMiceeIF-2 KinaseOsmotic PressureAnimalsHumansBiology (General)Hyperosmotic streQRNF-kappa BRNA-Binding ProteinsGenetics and GenomicsAdaptation, PhysiologicalHyperosmotic stress; NF-κB c-Rel; NF-κB p65; Osmoadaptation; PACT; PKR; TonEBPProto-Oncogene Proteins c-relGene Expression RegulationMedicineRNA InterferenceCarrier ProteinsSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good healthSDG 6: 6. Clean water

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (20)

Funding (16 grants)

Open Access

Topics

Annotations (Europe PMC)