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Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

eLife(2020)10.7554/elife.52687Source: DataRank Database

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway is a research paper published in eLife (2020). On theSindex it has a DataRank of 2.5. It has been cited 91 times, with 85 citing works in its 1-hop citation network.

N/A

2.5DataRank · unranked

Scored on demand from live citation data

Open Access91 citations · 85 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)OA: goldTopics (49)IDs (PubMed, PMC)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 27%Citation Network 73%

Base Score Contribution

0.678

From this paper's citation signal

Citation Network Contribution

1.8

From 69 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 85 citers.

Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions
npj Vaccines202326 citations36 referencesContributes 0.092
AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice
AAPS PharmSciTech202117 citations42 referencesContributes 0.069
Differential Regulation of DC Function, Adaptive Immunity, and MyD88 Dependence by Two Squalene Emulsion-Based Vaccine Adjuvants
Vaccines202416 citations43 referencesContributes 0.066
TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model
The Journal of Immunology202317 citations46 referencesContributes 0.063
Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast
Biotechnology for Biofuels and Bioproducts202225 citations52 referencesContributes 0.063

Authors (15)

Matthew C. Woodruff ORCID,Lilit Grigoryan ORCID,Barbara B. Maier ORCID,Song Hee Lee,Pratyusha Mandal ORCID

Live enrichment

PubMed:32515732 PMC:PMC7314549

National Institutes of Health

Grant: R37 DK057665

National Institutes of Health

Grant: R37 AI048638

National Institutes of Health

Grant: U19 AI057266

National Institutes of Health

Grant: U19 AI090023

NIAID NIH HHS

Grant: R38 AI140299

NCRR NIH HHS

Grant: S10 RR025679

NIAID NIH HHS

Grant: R01 AI048638

NIAID NIH HHS

Grant: R01 AI020211

NCATS NIH HHS

Grant: UL1 TR000454

National Institutes of Health

Grant: 1S10RR025679-01

FEI Transmission Electron Microscope with Tomography Capability

National Institutes of Health

Grant: 3U19AI057266-05S1

IMMUNOLOGICAL MEMORY TO VACCINATION

National Institutes of Health

Grant: 1U19AI090023-01

Systems Biological Analysis of Innate and Adaptive Responses to Vaccination

National Institutes of Health

Grant: 5UL1TR000454-07

Atlanta Clinical and Translational Science Institute (ACTSI) Renewal

National Institutes of Health

Grant: 5R37DK057665-19

Polarizing T Cell Responses in vivo With Dendritic Cells

National Institutes of Health

Grant: 5R37AI048638-12

Understanding the role of mucosal antigen presenting cells in regulating immune r

Bill and Melinda Gates Foundation

Soffer Fund

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.52687

publisherhttps://cdn.elifesciences.org/articles/52687/elife-52687-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/52687/elife-52687-v3.xml

publisherhttps://elifesciences.org/articles/52687

repositoryhttps://doaj.org/article/e62364c0766c48fdad9fa823a8b76041

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Lymph NodesCD8-Positive T-LymphocytesMacrophagesAnimalsMice, Inbred C57BLMicePolysorbatesSqualeneRepressor ProteinsAdjuvants, ImmunologicEmulsionsAntibody FormationBasic-Leucine Zipper Transcription FactorsReceptor-Interacting Protein Serine-Threonine KinasesImmunity, Innate

Keywords

MacrophageMouseVaccineInflammationCell deathAdjuvantimmunologyMf59Ripk3SqualeneQH301-705.5SciencePolysorbatesCD8-Positive T-LymphocytesMiceImmunology and InflammationAdjuvants, ImmunologicAnimalsBiology (General)MacrophagesQRImmunity, InnateMice, Inbred C57BLRepressor ProteinsBasic-Leucine Zipper Transcription FactorsReceptor-Interacting Protein Serine-Threonine KinasesAntibody FormationMedicineEmulsionsLymph Nodes

Sustainable Development Goals

SDG 3: 3. Good health