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scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

eLife(2021)10.7554/elife.64175Source: DataRank Database

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution is a research paper published in eLife (2021). On theSindex it has a DataRank of 1.7. It has been cited 62 times, with 50 citing works in its 1-hop citation network.

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1.7DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access62 citations · 50 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE161645

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)OA: goldTopics (39)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 37%Citation Network 63%

Base Score Contribution

0.621

From this paper's citation signal

Citation Network Contribution

1.1

From 42 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 50 citers.

AAV capsid bioengineering in primary human retina models
Scientific Reports202323 citations29 referencesContributes 0.110
Extensive length and homology dependent chimerism in pool-packaged AAV libraries
bioRxiv (Cold Spring Harbor Laboratory)20258 citations32 referencesContributes 0.069
Digital Technologies: Advancing Individualized Treatments through Gene and Cell Therapies, Pharmacogenetics, and Disease Detection and Diagnostics
Biomedicines202233 citations56 referencesContributes 0.063
Extended functional rescue following AAV gene therapy in a canine model of LRIT3-congenital stationary night blindness
Vision Research20238 citations35 referencesContributes 0.063
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion
Molecular Therapy202324 citations54 referencesContributes 0.060

Authors (19)

Molly Johnson ORCID,Michael Kleyman ORCID,Serhan Turunç,Jing He ORCID,Sara Jabalameli

Live enrichment

PubMed:19767382

National Eye Institute

Grant: F32EY023891

National Eye Institute

Grant: R24EY-022012

National Eye Institute

Grant: R01EY017549

National Eye Institute

Grant: P30EY001583

National Institute of Mental Health

Grant: UG3MH120094

National Institute of Mental Health

Grant: DP2MH113095

Research to Prevent Blindness

Grant: Career Development Award

Foundation Fighting Blindness

Grant: Individual Investigator Research Award

NIH/NEI

Grant: EY-06855

National Institutes of Health

Grant: 1DP2MH113095-01

Neural correlates of optimal value seeking in the reward system

National Institutes of Health

Grant: 5UG3MH120094-02

A Massive Library of AAVs to Target Transcriptionally-Defined Primate Cell Types

National Science Foundation

Grant: 1445606

Bridges: From Communities and Data to Workflows and Insight

National Institutes of Health

Grant: 2R01EY017549-06

Translational Research for Retinal Degeneration Therapies

National Institutes of Health

Grant: 5P30EY001583-15

CORE GRANT FOR VISION RESEARCH

National Science Foundation

Grant: 1928147

Category I: Bridges-2: Scalable Converged Computing, Data, and Analytics for Rapidly Evolving Science and Engineering Research

National Institutes of Health

Grant: 5F32EY023891-02

Optimizing Gene Therapies in Large Animal Models of Retinal Degeneration

National Institutes of Health

Grant: 1R24EY022012-01

Large animal therapy studies

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.64175

publisherhttps://cdn.elifesciences.org/articles/64175/elife-64175-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/64175/elife-64175-v3.xml

publisherhttps://elifesciences.org/articles/64175

repositoryhttps://doaj.org/article/2f839da7c7b643a2acc12975971ae2e2

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

medicineBiomedical and clinical sciencesQH301-705.5macaca fascicularisScienceMedical BiotechnologyGenetic Vectorsadeno-associated virusRetinaneuroscienceTransductionGeneticTransduction, GeneticRhesus macaqueGeneticsAnimalsBiology (General)Eye Disease and Disorders of Vision5.2 Cellular and gene therapiesInflammatory and immune systemGene Expression ProfilingQNeurosciencesRHealth sciencesGene TherapyDependovirusBiological sciencescallithrix jacchusscRNA-Seqretinal degenerationOtherBiochemistry and Cell BiologyDevelopment of treatments and therapeutic interventionsTranscriptomeBiotechnology

Sustainable Development Goals

SDG 3: 3. Good health