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HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

eLife(2021)10.7554/elife.64563Source: DataRank Database

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains is a research paper published in eLife (2021). On theSindex it has a DataRank of 0. It has been cited 242 times.

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Enrichment:Funding (33 grants)Impact (FWCI 13.03)OA: goldTopics (65)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC, OpenAlex)Annotations (2)

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Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (10)

David A. Brown ORCID,Lucy D. Brennan ORCID,Roman Renger ORCID,Harrison Khoo ORCID,Christopher R. Carlson ORCID

Live enrichment

PubMed:33661100 PMC:PMC7932698 OpenAlex:https://openalex.org/W3135396596

National Cancer Institute

Grant: F31CA243360

University of California, San Francisco

Grant: Discovery Fellows Program

National Cancer Institute

Grant: F99CA245719

NOMIS Stiftung

Grant: Graduate Student Fellowship

National Institute of General Medical Sciences

Grant: GM129652

National Institute of General Medical Sciences

Grant: GM131641

National Cancer Institute

Grant: CA231300

Chan Zuckerberg Initiative

Grant: Biohub Investigator

Deutsche Forschungsgemeinschaft

Grant: SPP 1782

Deutsche Forschungsgemeinschaft

Grant: GSC 97

Deutsche Forschungsgemeinschaft

Grant: GR 3271/2

Deutsche Forschungsgemeinschaft

Grant: GR 3271/3

Deutsche Forschungsgemeinschaft

Grant: GR 3271/4

H2020 European Research Council

Grant: 742712

Chiral Morphogenesis - Physical Mechanisms of Actomyosin-Based Left/Right Symmetry Breaking in Biological Systems

National Institute of General Medical Sciences

Grant: GM127020

National Science Foundation

Grant: 1921794

Collaborative Research: URoL: Epigenetics 2: Phase separated genome compartments as drivers of epigenetic phenotypes

University of California, San Francisco

Grant: Program for Breakthrough Biomedical Research

Marine Biological Laboratory

Grant: Whitman Fellowship

NIBIB NIH HHS

Grant: R21 EB022798

NIGMS NIH HHS

Grant: R35 GM127020

NIGMS NIH HHS

Grant: R21 GM129652

NCI NIH HHS

Grant: R01 CA231300

NIGMS NIH HHS

Grant: R01 GM124334

NIGMS NIH HHS

Grant: R01 GM131641

NIGMS NIH HHS

Grant: T32 GM007810

National Institutes of Health

Grant: 1R21GM129652-01

Rapid screening of gene-edited cells

National Institutes of Health

Grant: 5R35GM127020-02

ATP-dependent and independent mechanisms of regulating chromatin states

Deutsche Forschungsgemeinschaft

Grant: 24185540/GSC 97

Dresden International Graduate School for Biomedicine and Bioengineering

National Institutes of Health

Grant: 5R01GM131641-06

Mapping endogenous protein dynamics in living cells

National Institutes of Health

Grant: 5R01CA231300-03

(PQ7) Defining a new mode of RAS signaling in cancer from cytoplasmic protein granules

National Institutes of Health

Grant: 1F99CA245719-01

Dissecting the molecular mechanism of heterochromatin misregulation at the nuclear periphery in cancer

Deutsche Forschungsgemeinschaft

Grant: 255103767/SPP 1782

Epithelial intercellular junctions as dynamic hubs to integrate forces, signals and cell behaviour

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

FWCI

13.03

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.64563

publisherhttps://doi.org/10.7554/elife.64563

publisherhttps://cdn.elifesciences.org/articles/64563/elife-64563-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/64563/elife-64563-v1.xml

publisherhttps://elifesciences.org/articles/64563

Fields of Study

RNA Research and SplicingGenomics and Chromatin DynamicsRNA and protein synthesis mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesCells, CulturedChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNAHeterochromatinHumansProtein Binding

MeSH Terms

Chromobox Protein Homolog 5Cells, CulturedChromosomal Proteins, Non-HistoneDNAHeterochromatinHumansProtein Binding

Keywords

Heterochromatin protein 1HeterochromatinDNAPhase (matter)BiophysicsComponent (thermodynamics)GenomePhysicsDNA sequencingBiologyChemical physicsBiological systemChemistryEvolutionary biologyComputational biologyGeneticsChromatinGeneHumanBiochemistryPhase separationChromatin organizationStructural BiologyChemical BiologyMolecular BiophysicsChromobox Protein Homolog 5: geneticsQH301-705.5Chromosomal Proteins, Non-HistoneScienceChromobox Protein Homolog 5: metabolism612Biochemistry and Chemical BiologyHumansBiology (General)Cells, CulturedChromosomal Proteins, Non-Histone: geneticsDNA: metabolismQRHeterochromatin: metabolismChromosomal Proteins, Non-Histone: metabolismChromobox Protein Homolog 5info:eu-repo/classification/ddc/600MedicineProtein Binding

Additional file 4 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098410figshare

Additional file 4 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098410.v1figshare

Additional file 7 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098419figshare

Additional file 3 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098407.v1figshare

Additional file 3 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098407figshare

Additional file 2 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098404figshare

Additional file 5 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098413.v1figshare

Additional file 1 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098401.v1figshare

Additional file 7 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098419.v1figshare

Additional file 6 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098416.v1figshare

Additional file 2 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098404.v1figshare

Additional file 5 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098413figshare

Additional file 1 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098401figshare

Additional file 6 of CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

10.6084/m9.figshare.24098416figshare

Related Papers (10)

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

N/A

7.2DataRank · unranked

Molecular Cell(2020)

co-cited

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ALS‐linked mutations impair UBQLN2 stress‐induced biomolecular condensate assembly in cells

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Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding

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Taurine deficiency as a driver of aging

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10.1126/science.abn9257

The molecular basis of heterochromatin assembly and epigenetic inheritance

Molecular Cell(2023)

co-cited

10.1016/j.molcel.2023.04.020

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

FAIR Checklist

Authors (10)

Funding (33 grants)

Impact

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)

Related Papers (10)