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Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

eLife(2022)10.7554/elife.70826Source: DataRank Database

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy is a research paper published in eLife (2022). On theSindex it has a DataRank of 0.897. It has been cited 19 times, with 16 citing works in its 1-hop citation network.

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0.897DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access19 citations · 16 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE209630

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 1.25)OA: goldTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 50%Citation Network 50%

Base Score Contribution

0.449

From this paper's citation signal

Citation Network Contribution

0.448

From 12 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 16 citers.

Impaired Color Recognition in HCN1 Epilepsy: A Single Case Report
Frontiers in Neurology20229 citations19 referencesContributes 0.121
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy
Epilepsia202211 citations25 referencesContributes 0.099
Cation leak: a common functional defect causing HCN1 developmental and epileptic encephalopathy
Brain Communications20238 citations26 referencesContributes 0.085
The HCN1 p.Ser399Pro variant causes epileptic encephalopathy with super-refractory status epilepticus
Human Genome Variation20231 citations16 referencesContributes 0.043
Org 34167 rescues voltage dependence of mutant channels and normalizes hyperexcitability in HCN1 epilepsy
Epilepsia20252 citations28 referencesContributes 0.039

Authors (14)

Jacquelin Kasemir ORCID,Eric W. Buss ORCID,Félix Leroy ORCID,Tobias Bock ORCID,Alessandro Porro ORCID

Live enrichment

PubMed:35972069 PMC:PMC9481245 OpenAlex:https://openalex.org/W4292177663

National Institutes of Health

Grant: NS106983

National Institutes of Health

Grant: NS109366

National Institutes of Health

Grant: NS123648

Deutsche Forschungsgemeinschaft

Grant: FOR 2715 (IS63/10-1/2)

Deutsche Forschungsgemeinschaft

Grant: CRC 1451 (project ID 431549029 - B01)

Fondazione Telethon

Grant: GGP20021

NCI NIH HHS

Grant: P30 CA013696

NINDS NIH HHS

Grant: R01 NS106983

NINDS NIH HHS

Grant: R01 NS123648

NINDS NIH HHS

Grant: R01 NS109366

Deutsche Forschungsgemeinschaft

Grant: 377782854/FOR 2715

Epileptogenesis of genetic epilepsies

National Institutes of Health

Grant: 5P30CA013696-44

Cancer Center Support Grant

National Institutes of Health

Grant: 1R01NS123648-01

Role of HCN1 channels in the function and malfunction of parvalbumin positive interneurons

National Institutes of Health

Grant: 5R01NS109366-05

Structural Studies of HCN Channels in Health and Disease

National Institutes of Health

Grant: 5R01NS106983-05

The role of CA2 in epilepsy and social comorbidity

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

FWCI

1.25

Citation Percentile

0.8%

Influential Citations

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://elifesciences.org/articles/70826.bib

GOLDhttps://elifesciences.org/articles/70826.bib

publisherhttps://elifesciences.org/articles/70826.bib

publisherhttps://cdn.elifesciences.org/articles/70826/elife-70826-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/70826/elife-70826-v3.xml

Fields of Study

Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchEpilepsy research and treatmentBiologyMedicine0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsAnticonvulsantsBrain DiseasesChildHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsLamotrigineLigand-Gated Ion ChannelsMicePhenytoinPotassium ChannelsSeizures

MeSH Terms

LamotrigineAnimalsAnticonvulsantsBrain DiseasesChildHumansPhenytoinSeizuresPotassium ChannelsMiceLigand-Gated Ion ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Keywords

EpilepsyPhenotypeLamotriginePhenytoinNeuroscienceBiologyDravet syndromePharmacologyMedicineGeneGeneticsIon channelsMouseEpileptic EncephalopathyHcn1ddc:600Potassium ChannelsSeizures: geneticsQH301-705.5ScienceHyperpolarization-Activated Cyclic Nucleotide-Gated Channels: geneticsMiceSeizuresHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnimalsHumansBiology (General)Brain Diseases: geneticsChildBrain DiseasesQPotassium Channels: geneticsRLigand-Gated Ion ChannelsSeizures: drug therapyDravet syndrome; HCN1; epileptic encephalopathy; ion channels; lamotrigine; mouse; neuroscience; phenytoininfo:eu-repo/classification/ddc/600Anticonvulsants

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (14)

Funding (16 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)