Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

eLife(2022)10.7554/elife.73862Source: DataRank Database

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth is a research paper published in eLife (2022). On theSindex it has a DataRank of 0. It has been cited 14 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access14 citations

Download PDF

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)OA: goldTopics (65)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (39)

Stefania Ferrari ORCID,Matteo Santucci ORCID,Outi M. H. Salo‐Ahen ORCID,Emanuele Carosati ORCID,Silvia Franchini ORCID

Live enrichment

PubMed:36475542

Associazione Italiana per la Ricerca sul Cancro

Grant: IG25785

Associazione Italiana per la Ricerca sul Cancro

Grant: IG16977

Associazione Italiana per la Ricerca sul Cancro

Grant: 14422 Start-Up

CCA foundation grant

Grant: CCA2015-1-19

National Institute of General Medical Sciences

Grant: GM24485

Associazione Italiana per la Ricerca sul Cancro

Grant: IG23670

Ministero dell'Istruzione, dell'Università e della Ricerca

Grant: 2017XA5J5N

Academy of Finland

Grant: 137918

European Commission

Grant: GA037852

National Institutes of Health

Grant: 5R01GM024485-47

Molecular Basis for Transmembrane Conduction & Signaling

NIGMS NIH HHS

Grant: R01 GM024485

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.73862

publisherhttps://cdn.elifesciences.org/articles/73862/elife-73862-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/73862/elife-73862-v2.xml

publisherhttps://elifesciences.org/articles/73862

repositoryhttps://research.vumc.nl/en/publications/803eb8c1-115f-40c2-b0db-b8d16fd96d34

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciencesFemaleAnimalsMiceHumansBinding SitesThymidylate SynthaseFluorouracilOvarian NeoplasmsEnzyme Inhibitors

MeSH Terms

FemaleAnimalsMiceHumansBinding SitesThymidylate SynthaseFluorouracilOvarian NeoplasmsEnzyme Inhibitors

Keywords

proteasomal degradationBiomedical and clinical sciencesbiochemistry; cancer biology; chemical biology; humanMiceBiology (General)Enzyme Inhibitorsenzyme dissociative inhibition mechanismCancercancer biologyOvarian Neoplasmstarget engagementQRBiological SciencesOvarian Cancerbiochemistry; cancer biology; cancer growth inhibition; chemical biology; enzyme dissociative inhibition mechanism; human; proteasomal degradation; protein dimer destabilizers; target engagement; thymidylate synthase5.1 PharmaceuticalsMedicineFemaleFluorouracilBiotechnologyHuman570protein dimer destabilizersQH301-705.5ScienceOncology and CarcinogenesisAnimals; Binding Sites; Enzyme Inhibitors; Female; Fluorouracil; Humans; Mice; Ovarian Neoplasms; Thymidylate Synthasechemical biologythymidylate synthaseRare DiseasesBiochemistry and Chemical Biology615biochemistryAnimalsHumansBinding Sitesprotein dimer destabilizerHealth sciencescancer growth inhibitionOrphan DrugWomen's HealthBiochemistry and Cell BiologyDigestive Diseases

Sustainable Development Goals

SDG 3: 3. Good health