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Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

eLife(2022)10.7554/elife.78163Source: DataRank Database

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation is a research paper published in eLife (2022). On theSindex it has a DataRank of 0.807. It has been cited 27 times, with 21 citing works in its 1-hop citation network.

N/A

0.807DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access27 citations · 21 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE196666

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (21 grants)Impact (FWCI 2.10)OA: goldTopics (54)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 62%Citation Network 38%

Base Score Contribution

0.500

From this paper's citation signal

Citation Network Contribution

0.308

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 21 citers.

Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer
International Immunopharmacology202342 citations43 referencesContributes 0.087
MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5
Journal of Experimental & Clinical Cancer Research20246 citations45 referencesContributes 0.043
KMT2C and KMT2D aberrations in breast cancer
Trends in cancer202428 citations86 referencesContributes 0.039
Exploring promising natural compounds for breast cancer treatment: in silico molecular docking targeting WDR5-MYC protein interaction
Journal of Biomolecular Structure and Dynamics20243 citations42 referencesContributes 0.033
Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL
Blood20256 citations62 referencesContributes 0.031

Authors (19)

Jocelyn Fang-Yi Chen ORCID,Huacui Chen ORCID,Emily Wingrove,Sarah J. Kurley ORCID,Lok-Hei Chan ORCID

Live enrichment

PubMed:36043466 PMC:PMC9584608 OpenAlex:https://openalex.org/W4293765082

National Science Foundation

Grant: Graduate Research FellowshipDGE-1122492

National Cancer Institute

Grant: F31CA243295

Congressionally Directed Medical Research Programs

Grant: W81XWH-15-1-0117 and W81XWH-21-1-0411

National Cancer Institute

Grant: R01CA237586

National Cancer Institute

Grant: R01CA166376

National Cancer Institute

Grant: P30CA016359

Yale Cancer Center

Grant: Class of '61 Cancer Research Award

National Institutes of Health

Grant: 1S10OD025132 and 1S10OD028504

Yale Cancer Center

Grant: Class of '61 Cancer Research Award

NCATS NIH HHS

Grant: UL1 TR001863

NIH HHS

Grant: S10 OD028504

NCI NIH HHS

Grant: R01 CA268384

NIH HHS

Grant: S10 OD025132

NCI NIH HHS

Grant: T32 CA193200

National Institutes of Health

Grant: 1R01CA237586-01A1

TARGETING HISTONE DEMETHYLASE KDM5B IN BREAST CANCER

National Institutes of Health

Grant: 2P30CA016359-15

COMPREHENSIVE CANCER CENTER

National Institutes of Health

Grant: 5F31CA243295-03

THE ROLE OF CBX7 IN BREAST CANCER METASTASIZE TO THE BRAIN

National Science Foundation

Grant: 1122492

Graduate Research Fellowship Program

National Institutes of Health

Grant: 1S10OD025132-01A1

An AVANCE NEO 600 MHz NMR Spectrometer System for Structural and Chemical Biology

National Institutes of Health

Grant: 1R01CA166376-01A1

A Novel Lineage Specific Metastasis Suppressor Pathway in Lung Cancer

National Institutes of Health

Grant: 1S10OD028504-01

An AVANCE NEO 400 MHz NMR Spectrometer for Chemical Biology and Drug Discovery

FWCI

2.10

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.78163

publisherhttps://doi.org/10.7554/elife.78163

publisherhttps://cdn.elifesciences.org/articles/78163/elife-78163-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/78163/elife-78163-v2.xml

publisherhttps://elifesciences.org/articles/78163

Fields of Study

Cancer-related gene regulationEpigenetics and DNA MethylationRNA modifications and cancer03 medical and health sciences0302 clinical medicine

MeSH Terms

Breast NeoplasmsFemaleHumansHistone-Lysine N-MethyltransferaseCell Line, TumorIntracellular Signaling Peptides and ProteinsCell Proliferation

Keywords

Breast cancerCancer researchGene knockdownMetastasisEpigeneticsClonogenic assayCancerPI3K/AKT/mTOR pathwayBiologyTriple-negative breast cancerTranslation (biology)Metastatic breast cancerMedicineInternal medicineIn vivoSignal transductionCell cultureGeneMessenger RNACell biologyGeneticsCancer metastasisMousechromosomesGene ExpressionCancer BiologyMllTranslation RegulationWdr5Kmt2QH301-705.5ScienceQRIntracellular Signaling Peptides and ProteinsBreast NeoplasmsHistone-Lysine N-MethyltransferaseCell Line, TumorHumansFemaleBiology (General)Cell Proliferation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being