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Z-REX uncovers a bifurcation in function of Keap1 paralogs

eLife(2022)10.7554/elife.83373Source: DataRank Database

Z-REX uncovers a bifurcation in function of Keap1 paralogs is a research paper published in eLife (2022). On theSindex it has a DataRank of 0. It has been cited 14 times.

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Open Access14 citations

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cellosaurus pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)Impact (FWCI 0.86)OA: goldTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Jesse R. Poganik ORCID,Kuan‐Ting Huang ORCID,Saba Parvez ORCID,Yi Zhao ORCID,Hongyu Lin ORCID

Live enrichment

PubMed:36300632 PMC:PMC9754640 OpenAlex:https://openalex.org/W4307362500

European Research Council

Grant: 101043303

National Institutes of Health

Grant: NIH T32GM008500

AHA predoctoral Fellowship

Grant: 17PRE33670395

NIGMS NIH HHS

Grant: T32 GM008500

National Institutes of Health

Grant: 2T32GM008500-16

Chemistry of Biological Systems

Swiss Federal Institute of Technology Lausanne

Novartis FreeNovation

HHMI International Fellow

Howard Hughes Medical Institute

FWCI

0.86

Citation Percentile

0.7%

Citation Trend

2023

2024

2026

goldLicense: cc-by

journalhttps://elifesciences.org/articles/83373.bib

publisherhttps://elifesciences.org/articles/83373.bib

publisherhttps://cdn.elifesciences.org/articles/83373/elife-83373-v4.pdf

publisherhttps://cdn.elifesciences.org/articles/83373/elife-83373-v4.xml

publisherhttps://elifesciences.org/articles/83373

Fields of Study

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsBiochemical Acid Research Studies0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsHumansKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2ZebrafishAntioxidantsSignal Transduction

MeSH Terms

Kelch-Like ECH-Associated Protein 1AnimalsAntioxidantsHumansZebrafishSignal TransductionNF-E2-Related Factor 2

Keywords

ElectrophileKEAP1Downregulation and upregulationCell biologySignal transductionGene knockdownBiologymTORC1GeneticsTranscription factorBiochemistryGenePI3K/AKT/mTOR pathwayZebrafishChemical BiologyElectrophile SignalingKeap1/nrf2 Antioxidant ResponseRex TechnologiesCovalent Drug Mode-of-actionParalog-specific SignalingKelch-Like ECH-Associated Protein 1QH301-705.5NF-E2-Related Factor 2ScienceQRAntioxidantsBiochemistry and Chemical BiologyAnimals; Humans; Kelch-Like ECH-Associated Protein 1/genetics; Kelch-Like ECH-Associated Protein 1/metabolism; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; Zebrafish/metabolism; Antioxidants/metabolism; Signal Transduction; Keap1/Nrf2 antioxidant response; REX technologies; biochemistry; chemical biology; covalent drug mode-of-action; electrophile signaling; paralog-specific signaling; zebrafishMedicineAnimalsHumansBiology (General)

Z-REX uncovers a bifurcation in function of Keap1 paralogs

FAIR Checklist

Authors (9)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)