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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

eLife(2023)10.7554/elife.88206Source: DataRank Database

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology is a research paper published in eLife (2023). On theSindex it has a DataRank of 0.535. It has been cited 15 times, with 7 citing works in its 1-hop citation network.

N/A

0.535DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access15 citations · 7 citing works in its network

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Linked data & code

omim hpa refseq pdb

Data availability

Repositories this paper deposited data in (declared in PubMed).

Dryad10.5061/dryad.sn02v6x88

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 3.24)OA: goldTopics (65)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 78%Citation Network 22%

Base Score Contribution

0.416

From this paper's citation signal

Citation Network Contribution

0.119

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 7 citers.

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Authors (19)

Margaux Silvestre ORCID,Carrow I. Wells ORCID,Jennifer L. Sanderson ORCID,Carla A. Ferrer,Han Wee Ong ORCID

Live enrichment

PubMed:37490324 PMC:PMC10406435 OpenAlex:https://openalex.org/W4385230232

National Institute of Neurological Disorders and Stroke

Grant: NS112770

Children's Hospital Colorado Foundation

Grant: Ponzio Family Chair in Neuroscience Research

NC Biotechnology Center Institutional Support Grant

Grant: 2018-IDG-1030

National Institutes of Health

Grant: U24DK116204

National Institutes of Health

Grant: R44TR001916

Cancer Research UK

Grant: CC2037

Kinases and Brain Development Laboratory

LouLou Foundation

Grant: 11015

NINDS NIH HHS

Grant: R21 NS112770

European Commission

Grant: 875510

EUbOPEN: Enabling and Unlocking biology in the OPEN

National Institutes of Health

Grant: 1R21NS112770-01A1

Pilot studies to characterize CDKL5 inhibitors

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5U24DK116204-04

Illuminating Function of the Understudied Druggable Kinome

National Institutes of Health

Grant: 5R44TR001916-02

Tools for Accelerating R&D for Historically Understudied Protein Kinases

Structural Genomics Consortium

FWCI

3.24

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.88206

publisherhttps://doi.org/10.7554/elife.88206

publisherhttps://cdn.elifesciences.org/articles/88206/elife-88206-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/88206/elife-88206-v3.xml

publisherhttps://elifesciences.org/articles/88206

Fields of Study

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanismsMicrotubule and mitosis dynamics03 medical and health sciences0302 clinical medicineEpileptic SyndromesGlycogen Synthase Kinase 3 betaSpasms, InfantileMice, KnockoutHumansMiceAnimalsHippocampusCyclin-Dependent KinasesProtein Serine-Threonine KinasesCDKL5 deficiency disorder

MeSH Terms

Glycogen Synthase Kinase 3 betaEpileptic SyndromesAnimalsHippocampusHumansSpasms, InfantileProtein Serine-Threonine KinasesMice, KnockoutCyclin-Dependent KinasesMice

Keywords

KinaseThreonineSerineHippocampal formationCell biologyProtein kinase AProtein-Serine-Threonine KinasesDYRK1ABiologyChemistryBiochemistryPhosphorylationNeuroscienceProtein kinaseHippocampusRatLTPGsk3Cdkl5QH301-705.5ScienceProtein Serine-Threonine KinasesMiceSignalling & OncogenesHumansAnimalsBiology (General)Mice, KnockoutChemical Biology & High ThroughputGlycogen Synthase Kinase 3 betaFOS: Clinical medicineQRNeurosciencesCyclin-Dependent KinasesMedicineEpileptic SyndromesSpasms, InfantileDevelopmental Biology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being