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The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

eLife(2023)10.7554/elife.89967Source: DataRank Database

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults is a research paper published in eLife (2023). On theSindex it has a DataRank of 0.345. It has been cited 6 times, with 5 citing works in its 1-hop citation network.

N/A

0.345DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access6 citations · 5 citing works in its network

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Linked data & code

gen refsnp

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE239566

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 1.67)OA: goldTopics (78)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 84%Citation Network 16%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

0.0536

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 5 citers.

The crucial role of potassium ion channels in diabetes mellitus and its complications: A review
Channels20255 citations76 referencesContributes 0.024
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
Journal of Clinical Investigation20256 citations104 referencesContributes 0.019
Comparative transcriptomic and molecular interaction analysis of olive polyphenols: Unraveling their mechanisms in immune regulation and metabolic processes in adipocytes
Computers in Biology and Medicine20251 citations60 referencesContributes 0.012
Linking molecular pathways and islet cell dysfunction in human type 1 diabetes
bioRxiv (Cold Spring Harbor Laboratory)20252 citations119 referencesContributes 0.009
KCNK 16 Deficiency Deteriorates Body Growth and Diet‐Independently Decreases Lipid Accumulation in Mice
Comprehensive physiology20260 citations34 referencesContributes 0.000

Authors (11)

Prasanna K. Dadi ORCID,Jin‐Sun Kim ORCID,Matthew T. Dickerson ORCID,Soma Behera,Jordyn R Dobson ORCID

Live enrichment

PubMed:38700926 PMC:PMC11068355 OpenAlex:https://openalex.org/W4386896964

National Institutes of Health

Grant: R01DK097392

National Institutes of Health

Grant: R01DK129340

National Institutes of Health

Grant: R01DK115620

NCI NIH HHS

Grant: P30 CA068485

NIDDK NIH HHS

Grant: P30 DK020593

NIDDK NIH HHS

Grant: R01 DK136768

NIDDK NIH HHS

Grant: U2C DK059637

National Institutes of Health

Grant: 5R01DK129340-04

Molecular Mechanisms Regulating Pancreatic Delta Cell Function and Dysfunction

National Institutes of Health

Grant: 5P60DK020593-25

Diabetes Research and Training Center

National Institutes of Health

Grant: 3P30CA068485-23S2

Cancer Center Support Grant

National Institutes of Health

Grant: 5R01DK097392-08

Two-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone Secretion

National Institutes of Health

Grant: 5R01DK115620-03

Designing selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetes

National Institutes of Health

Grant: 5U2CDK059637-19

Vanderbilt Mouse Metabolic Phenotyping Center

FWCI

1.67

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://elifesciences.org/reviewed-preprints/89967.pdf

publisherhttps://elifesciences.org/reviewed-preprints/89967.pdf

publisherhttps://cdn.elifesciences.org/articles/89967/elife-89967-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/89967/elife-89967-v1.xml

publisherhttps://elifesciences.org/articles/89967

Fields of Study

Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsMaleMiceAnimals, NewbornDiabetes Mellitus, Type 2Disease Models, AnimalGlucagonGlucoseHomeostasisInsulinInsulin SecretionIslets of LangerhansMice, Inbred C57BLMutationPotassium ChannelsPotassium Channels, Tandem Pore DomainMaturity-Onset Diabetes of the Young, Type 2

MeSH Terms

Insulin SecretionAnimalsAnimals, NewbornDiabetes Mellitus, Type 2Disease Models, AnimalGlucagonGlucoseHomeostasisInsulinIslets of LangerhansMaleMice, Inbred C57BLMutationPotassium ChannelsPotassium Channels, Tandem Pore DomainMice

Keywords

EndocrinologyInternal medicineIsletSecretionGlucagonInsulinDiabetes mellitusInsulin oscillationMedicineMutationBiologyGeneticsGeneCalciumMousesystems biologycomputational biologydevelopmental biologyMonogenic DiabetesTalk-1MalePotassium ChannelsQH301-705.5ScienceMiceIslets of LangerhansPotassium Channels, Tandem Pore DomainInsulin SecretionAnimalsHomeostasisBiology (General)QRMice, Inbred C57BLDisease Models, AnimalGlucoseAnimals, NewbornDiabetes Mellitus, Type 2Computational and Systems Biology

Sustainable Development Goals

SDG 0: Good health and well-being