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Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons

eLife(2024)10.7554/elife.92915Source: DataRank Database

Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons is a research paper published in eLife (2024). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)OA: goldTopics (77)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Keyong Li ORCID,Mona Safari ORCID,Alshaima’a M. Qunies ORCID,Brittany D. Spitznagel ORCID,C. David Weaver ORCID

Live enrichment

PubMed:39392867 PMC:PMC11469685 OpenAlex:https://openalex.org/W4390705165

NIH/NINDS

Grant: R01NS130042

NIH/NINDS

Grant: R01NS031348

NIH/NINDS

Grant: R33NS109521

NIH/NINDS

Grant: U54OD020351

NIH/NINDS

Grant: R01 NS110945

National Institutes of Health

Grant: 4R33NS109521-02

Slack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies

National Institutes of Health

Grant: 1U54OD020351-01

Project 1 - Epilepsy Project

National Institutes of Health

Grant: 5R01NS130042-04

Cell Type-Specific Roles of the Na-Activated K Current in KCNT1-Related Epilepsy

National Institutes of Health

Grant: 5R01NS110945-02

Synaptic changes and hypersynchronous network activity in mTORopathies

National Institutes of Health

Grant: 5R01NS031348-04

GENETIC DETERMINANTS OF EPILEPSY

goldLicense: cc-by

journalhttps://github.com/elifesciences/enhanced-preprints-data/raw/master/data/92915/v1/92915-v1.pdf

publisherhttps://github.com/elifesciences/enhanced-preprints-data/raw/master/data/92915/v1/92915-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/92915/elife-92915-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/92915/elife-92915-v1.xml

publisherhttps://elifesciences.org/articles/92915

Fields of Study

Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchEpilepsy research and treatment03 medical and health sciences0302 clinical medicineAnimalsSomatostatinMiceGABAergic NeuronsParvalbuminsGain of Function MutationHeterozygoteCerebral CortexMaleAction PotentialsFemaleMutation, MissensePotassium Channels, Voltage-Gated

MeSH Terms

Gain of Function MutationAction PotentialsAnimalsCerebral CortexFemaleHeterozygoteMaleParvalbuminsSomatostatinMutation, MissensePotassium Channels, Voltage-GatedMiceGABAergic Neurons

Keywords

GlutamatergicNeuroscienceBiologyRheobaseGABAergicNeuronAfterhyperpolarizationChannelrhodopsinExcitatory postsynaptic potentialParvalbuminPremovement neuronal activityPatch clampElectrophysiologyGlutamate receptorOptogeneticsInhibitory postsynaptic potentialReceptorGeneticsCortexEpilepsyMouseModelingAction potentialInterneuronStructural BiologyKcnt1Molecular BiophysicsMaleHeterozygoteQH301-705.5ScienceMutation, MissenseAction PotentialsMiceAnimalsBiology (General)GABAergic NeuronsCerebral CortexQRParvalbuminsPotassium Channels, Voltage-GatedGain of Function MutationMedicineFemaleSomatostatin

Sustainable Development Goals

SDG 0: Good health and well-being