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Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9

eLife(2024)10.7554/elife.99275Source: DataRank Database

Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9 is a research paper published in eLife (2024). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Enrichment:Funding (16 grants)OA: goldTopics (20)IDs (PubMed)

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Authors (9)

Alexa L Knight ORCID,Alexandra M. D’Ordine ORCID,Chinmai Pindi ORCID,Zhi-Qiang Fan ORCID,Jinping Luo ORCID

Live enrichment

PubMed:21097893

National Institutes of Health

Grant: R01GM136815

National Science Foundation

Grant: MCB2143760

National Institutes of Health

Grant: R01GM141329

National Science Foundation

Grant: CHE2144823

Alfred P. Sloan Foundation

Grant: FG-2023-20431

Camille and Henry Dreyfus Foundation

Grant: TC-24-063

National Science Foundation

Grant: 2138286

Track 2: Customized Multi-tier Assistance, Training, and Computational Help (MATCH) for End User ACCESS to CI

National Institutes of Health

Grant: 5R01GM136815-04

Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes

National Science Foundation

Grant: 2138307

Track 3: COre National Ecosystem for CyberinfrasTructure (CONECT)

National Science Foundation

Grant: 2143760

CAREER: Molecular Resolution of Long-range Allostery in CRISPR-Cas9

National Science Foundation

Grant: 2137603

Track 4: Advanced CI Coordination Ecosystem: Monitoring and Measurement Services

National Science Foundation

Grant: 2144823

CAREER: Mechanistic Investigations of Conformational Activation and Catalysis in Emerging CRISPR-Cas Systems

National Institutes of Health

Grant: 5P30GM133893-04

The Center for Biomolecular Structure at NSLS-II

National Science Foundation

Grant: 2138296

ACO: An Open CI Ecosystem to Advance Scientific Discovery (OpenCI)

National Institutes of Health

Grant: 3R01GM141329-05S1

Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9

National Science Foundation

Grant: 2138259

Track 1: ACCESS Resource Allocations Marketplace and Platform Services (RAMPS)

goldLicense: cc-by

publisherhttps://github.com/elifesciences/enhanced-preprints-data/raw/master/data/99275/v1/99275-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/99275/elife-99275-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/99275/elife-99275-v1.xml

publisherhttps://elifesciences.org/articles/99275

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12088677

Fields of Study

0301 basic medicine03 medical and health sciences

Keywords

allosteryQH301-705.5Protein ConformationScienceStructural Biology and Molecular BiophysicsQRspecificityRNA, Guide, CRISPR-Cas Systemsmolecular dynamicsGeobacillus stearothermophilusNMR spectroscopyBacterial ProteinsCRISPR-Associated Protein 9MedicineCRISPR-Cas9Biology (General)CRISPR-Cas Systems