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JAK inhibition decreases the autoimmune burden in Down syndrome

eLife(2024)10.7554/elife.99323Source: DataRank Database

JAK inhibition decreases the autoimmune burden in Down syndrome is a research paper published in eLife (2024). On theSindex it has a DataRank of 0.670. It has been cited 28 times, with 21 citing works in its 1-hop citation network.

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0.670DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access28 citations · 21 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE251967 GSE190125
ClinicalTrials.govNCT04246372

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)OA: goldTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 75%Citation Network 25%

Base Score Contribution

0.505

From this paper's citation signal

Citation Network Contribution

0.164

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 21 citers.

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Authors (22)

Elizabeth Wallace ORCID,Emily Gurnee,Belinda A Enriquez Estrada,Kayleigh R Worek,Keith P. Smith ORCID

Live enrichment

PubMed:39737640 PMC:PMC11687933 OpenAlex:https://openalex.org/W4401418906

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Grant: R61AR077495

National Institute of Allergy and Infectious Diseases

Grant: R01AI150305

National Cancer Institute

Grant: T32CA190216

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Grant: 2T32AR007411-31

National Center for Advancing Translational Sciences

Grant: UM1TR004399

National Cancer Institute

Grant: P30CA046934

NIAMS NIH HHS

Grant: R33 AR077495

NIAMS NIH HHS

Grant: T32 AR007411

National Institutes of Health

Grant: 2T32AR007411-31A1

Training in Immunodermatology

National Institutes of Health

Grant: 3P30CA046934-20S2

Cancer Center Support Grant

National Institutes of Health

Grant: 1UM1TR004399-01A1

Colorado Clinical and Translational Sciences Institute (CCTSI)

National Institutes of Health

Grant: 1R61AR077495-01

JAK Inhibition in Down Syndrome

National Institutes of Health

Grant: 1R01AI150305-01

Understanding Down Syndrome as an Interferonopathy

National Institutes of Health

Grant: 5T32CA190216-03

Training Program in Cancer Biology

Boettcher Foundation

Global Down Syndrome Foundation

Anna and John J. Sie Foundation

Fast Grants

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.99323

publisherhttps://doi.org/10.7554/elife.99323

publisherhttps://cdn.elifesciences.org/articles/99323/elife-99323-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/99323/elife-99323-v1.xml

publisherhttps://elifesciences.org/articles/99323

Fields of Study

Down syndrome and intellectual disability researchImmunodeficiency and Autoimmune DisordersDiabetes and associated disorders0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Janus Kinase InhibitorsAdolescentAdultAutoantibodiesChildChild, PreschoolDown SyndromeFemaleHumansInfantMaleMiddle AgedPiperidinesPyrimidinesPyrrolesAutoimmunityCytokinesYoung Adult

Keywords

Autoimmune diseaseMedicineImmunologyBiologyAntibodyHumanInterferonsInflammationAutoimmunityJAKDown syndromeSKinAdultMaleAdolescentQH301-705.5ScienceArticleYoung AdultImmunology and InflammationPiperidinesHumansJanus Kinase InhibitorsPyrrolesBiology (General)ChildAutoantibodiesQRInfantMiddle AgedPyrimidinesChild, PreschoolCytokinesFemale

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being