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Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

eLife(2024)10.7554/elife.99575Source: DataRank Database

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic is a research paper published in eLife (2024). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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gen uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: goldTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Sophia B Scobell ORCID,Meru J. Sadhu ORCID,Michael Chambers ORCID

Live enrichment

PubMed:39531012 PMC:PMC11556786 OpenAlex:https://openalex.org/W4401819879

National Human Genome Research Institute

Grant: 1ZIAHG200401

Intramural NIH HHS

Grant: ZIA HG200401

goldLicense: cc-by

journalhttps://elifesciences.org/reviewed-preprints/99575.pdf

publisherhttps://elifesciences.org/reviewed-preprints/99575.pdf

publisherhttps://cdn.elifesciences.org/articles/99575/elife-99575-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/99575/elife-99575-v1.xml

publisherhttps://elifesciences.org/articles/99575

Fields of Study

Virus-based gene therapy researchPoxvirus research and outbreaksCRISPR and Genetic Engineering

MeSH Terms

Protein DomainsHumansPoxviridaeVaccinia virusViral ProteinsEukaryotic Initiation Factor-2Evolution, MoleculareIF-2 KinasePolymorphism, Single Nucleotide

Keywords

Protein kinase RBiologyProtein kinase AViral replicationEIF-2 kinaseCell biologyGeneticsKinaseComputational biologyVirusMitogen-activated protein kinase kinaseCyclin-dependent kinase 2HumanVirusesS. cerevisiaeGenomicsEvolutionary BiologyPkrK3Deep Mutational ScanningK3l

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

FAIR Checklist

Authors (3)

Funding (2 grants)

Open Access

Topics

Annotations (Europe PMC)