H. Ümit Kanıskan

Also affiliated with Icahn School of Medicine at Mount Sinai

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 51 papers. Top paper: “Cancer Selective Target Degradation by Folate-Caged PROTACs”.

Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society(2021)10.1021/jacs.1c00451

N/A

8.4DataRank · unranked

292 citations

He Chen, Yi Liu, Yudao Shen, Fanye Meng, H. Ümit Kanıskan +3 more

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Neuron(2020)10.1016/j.neuron.2020.11.002

N/A

0.806DataRank · unranked

215 citations

Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode +37 more

Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00901

N/A

0.712DataRank · unranked

114 citations

Jing Liu, H. Ümit Kanıskan, Wenyi Wei, Jian Jin, He Chen

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

Cell chemical biology(2021)10.1016/j.chembiol.2021.08.004

N/A

0.624DataRank · unranked

63 citations

Fanye Meng, Kwang‐Su Park, Aaron J. Storey, Weida Gong, Yi‐Hsuan Tsai +12 more

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00100

N/A

0.621DataRank · unranked

62 citations

Chris Anderson, Kwang‐Su Park, H. Ümit Kanıskan, Anqi Ma, Yudao Shen +6 more

Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c02120

N/A

0.587DataRank · unranked

49 citations

Fengling Li, Elissa A. Fink, Irene Chau, Alice Shi Ming Li, Annia Rodríguez‐Hernández +18 more

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116154

N/A

0.546DataRank · unranked

37 citations

Brandon Dale, Kwang‐Su Park, H. Ümit Kanıskan, Xufen Yu, Jian Jin +1 more

Chemically induced degradation of epigenetic targets

Chemical Society Reviews(2023)10.1039/d3cs00100h

N/A

0.510DataRank · unranked

29 citations

Xufen Yu, H. Ümit Kanıskan, Jian Jin, Md Kabir

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Advanced Science(2023)10.1002/advs.202205573

N/A

0.505DataRank · unranked

28 citations

Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong +5 more

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice

Science Translational Medicine(2023)10.1126/scitranslmed.adh7668

N/A

0.449DataRank · unranked

19 citations

Lei Bai, Jiazhen Dong, Xiaoping Hu, Jingchao Wang, Joao A. Paulo +22 more

Discovery of the first-in-class DOT1L PROTAC degrader

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117595

N/A

0.345DataRank · unranked

9 citations

Renhong Sun, Zhongli Xu, Huen Suk Kim, Min Jeong Kim, Tao Cao +5 more

Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes

Digital Discovery(2024)10.1039/d4dd00006d

N/A

0.345DataRank · unranked

9 citations

Matthew F. D. Hurley, Fengling Li, Eva Konkoľová, Martin Klíma, Jana Trylčová +21 more

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.19.517138

N/A

0.178DataRank · unranked

2 citations

Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong +5 more

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.03.560722

N/A

0.165DataRank · unranked

2 citations

Matthew F. D. Hurley, Fengling Li, Eva Konkoľová, Martin Klíma, Jana Trylčová +21 more

Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1

Cell Death and Differentiation(2023)10.1038/s41418-023-01180-7

N/A

0DataRank · unranked

62 citations

Huan Li, Bo Chu, Ning Kon, Xiaoping Hu, Jianping Hu +5 more

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53

Journal of the American Chemical Society(2023)10.1021/jacs.3c04640

N/A

0DataRank · unranked

55 citations

Ning Sun, Xiaoping Hu, Tiphaine Martin, Jingjie Yi, Yue Zhong +6 more

Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

Cell Host & Microbe(2023)10.1016/j.chom.2023.05.030

N/A

0DataRank · unranked

39 citations

Jessica Ho, Fanye Meng, Simin Zheng, Andrew P. Kurland, Lu Tian +11 more

Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins

Journal of the American Chemical Society(2023)10.1021/jacs.3c02783

N/A

0DataRank · unranked

30 citations

Jing Liu, He Chen, Xing Qiu, Ling Xie, H. Ümit Kanıskan +4 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00651

N/A

0DataRank · unranked

22 citations

Davide Provasi, Xing Qiu, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement

Cell(2023)10.1016/j.cell.2023.09.009

N/A

0DataRank · unranked

18 citations

Damayanti Chakraborty, Reuben R. Duttweiler, Gulnaz D. Alekbaeva, Sedona E. Murphy, Kashish Chetal +21 more

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2

Journal of the American Chemical Society(2023)10.1021/jacs.3c06023

N/A

0DataRank · unranked

13 citations

Jing Liu, Xing Qiu, Dingpeng Zhang, Hiroyuki Inuzuka, Li Chen +7 more

Recent advances in developing degraders & inhibitors of lysine methyltransferases

Current Opinion in Chemical Biology(2023)10.1016/j.cbpa.2023.102356

N/A

0DataRank · unranked

10 citations

H. Ümit Kanıskan, Jian Jin, Julia Velez

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7 -methyltransferase

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.12.523677

N/A

0DataRank · unranked

2 citations

Fengling Li, Elissa A. Fink, Irene Chau, Alice Li, Annia Rodríguez‐Hernández +18 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.25.537995

N/A

0DataRank · unranked

1 citations

Davide Provasi, Xing Qui, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.12.544352

N/A

0DataRank · unranked

1 citations

James M. Vicari, Bik Tzu Huang, Lila Shapiro, Kun-Hyung Roh, Aaron E. Silver +10 more

Data from SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

(2023)10.1158/1078-0432.c.6530477

N/A

0DataRank · unranked

0 citations

Stephanie Christie, Violetta V. Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano +13 more

Data from SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

(2023)10.1158/1078-0432.c.6530477.v1

N/A

0DataRank · unranked

0 citations

Stephanie Christie, Violetta V. Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano +13 more

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1

Journal of the American Chemical Society(2024)10.1021/jacs.3c13646

N/A

0DataRank · unranked

30 citations

Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu +8 more

A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

Science Advances(2024)10.1126/sciadv.ado1432

N/A

0DataRank · unranked

14 citations

Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie +10 more

Discovery of the First-in-Class G9a/GLP PROTAC Degrader

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c02394

N/A

0DataRank · unranked

12 citations

Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang‐Su Park +5 more

Discovery of the First-in-class G9a/GLP PROTAC Degrader

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.26.582210

N/A

0DataRank · unranked

2 citations

Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang‐Su Park +5 more

Novel Insights into SOX11 Modulation of BCR Signaling and Targeting of BTK Resistance

Blood(2024)10.1182/blood-2024-210591

N/A

0DataRank · unranked

1 citations

Heng‐Huan Lee, Ravi Prakash Shukla, Violetta V. Leshchenko, Fanye Meng, Fangfang Yan +7 more

Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00295

N/A

0DataRank · unranked

12 citations

Jerrel L. Catlett, Youngeun Lee, Qiong Wu, Zhongli Xu, Ling Xie +5 more

Structure–Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02161

N/A

0DataRank · unranked

5 citations

Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit +9 more

Targeting the Mitochondrial Protease ClpP for Anticancer Therapy

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01315

N/A

0DataRank · unranked

3 citations

Dmitry Pokushalov, Md Kabir, Youngeun Lee, Mrittika Chattopadhyay, Edmund C. Jenkins +5 more

Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype

Molecular Psychiatry(2025)10.1038/s41380-025-02972-8

N/A

0DataRank · unranked

5 citations

Jianping Hu, Hsiao‐Yun Lin, Rachel Fisher-Foye, Anthony Blando, Xiaoping Hu +10 more

SOX11 modulates BCR signaling through the PAX5/CD19 axis for therapeutic targeting in BTK-resistant mantle cell lymphoma

Blood Advances(2025)10.1182/bloodadvances.2025016801

N/A

0DataRank · unranked

3 citations

Heng‐Huan Lee, Violetta V. Leshchenko, Ravi Prakash Shukla, Fangfang Yan, Yang Liu +7 more

Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma

iScience(2025)10.1016/j.isci.2025.112387

N/A

0DataRank · unranked

3 citations

Reshmee Bhattacharya, Seungyeul Yoo, Feng Jiang, Eric Park, Genesis Lara Granados +8 more

Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions

Medicinal Research Reviews(2020)10.1002/med.21764

N/A

0DataRank · unranked

415 citations

Avner Schlessinger, Daniel Wacker, H. Ümit Kanıskan, Jian Jin, Ming‐Ming Zhou +2 more

A First-in-class, Highly Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.04.412569

N/A

0DataRank · unranked

1 citations

Fengling Li, Magdalena M. Szewczyk, Levon Halebelian, Irene Chau, Mohammad S. Eram +19 more

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

UNC Libraries(2020)10.17615/s278-v194

N/A

0DataRank · unranked

0 citations

Luo Xiao, Magdalena M. Szewczyk, Masoud Vedadi, Aiping Dong, David Smil +24 more

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Journal of the American Chemical Society(2021)10.1021/jacs.1c03852

N/A

0DataRank · unranked

233 citations

He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen, Jian Jin +2 more

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Science Translational Medicine(2021)10.1126/scitranslmed.abj1578

N/A

0DataRank · unranked

158 citations

Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang‐Su Park +14 more

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Journal of the American Chemical Society(2021)10.1021/jacs.1c04841

N/A

0DataRank · unranked

144 citations

Fanye Meng, Kwang‐Su Park, Hyerin Yim, Julia Velez, Prashasti Kumar +11 more

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Neuropharmacology(2021)10.1016/j.neuropharm.2021.108673

N/A

0DataRank · unranked

34 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.0c02160

N/A

0DataRank · unranked

27 citations

Fengling Li, Magdalena M. Szewczyk, Levon Halabelian, Irene Chau, Mohammad S. Eram +22 more

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.24.445057

N/A

0DataRank · unranked

0 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors

Journal of the American Chemical Society(2022)10.1021/jacs.2c04824

N/A

0DataRank · unranked

61 citations

Xufen Yu, He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen +3 more

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00807

N/A

0DataRank · unranked

58 citations

Chenxi Xu, Kwang‐Su Park, H. Ümit Kanıskan, Gang Greg Wang, Jian Jin +1 more

Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01505

N/A

0DataRank · unranked

38 citations

Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez +4 more

An MDM2 degrader for treatment of acute leukemias

Leukemia(2022)10.1038/s41375-022-01735-6

N/A

0DataRank · unranked

34 citations

Xiaobao Yang, H. Ümit Kanıskan, Claudia Brady, He Chen, Karie Chen +13 more