Michael Regnier

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 54 papers. Top paper: “Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts”.

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

eLife(2022)10.7554/elife.74919

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0.992DataRank · unranked

22 citations

Matthew C. Childers, Amanda L. Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh +10 more

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

Archives of Biochemistry and Biophysics(2020)10.1016/j.abb.2020.108733

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14 citations

Michael A. Geeves, Valerie Daggett, Michael Regnier, Matthew C. Childers

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics(2020)10.1016/j.abb.2020.108582

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10 citations

Yasser Aboelkassem, Abigail E. Teitgen, Gary Huber, J. Andrew McCammon, Michael Regnier +2 more

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP

The Journal of Physiology(2020)10.1113/jp280402

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37 citations

Matthew C. Childers, Jason D. Murray, Farid Moussavi‐Harami, Henry Gong, Robert S. Weiss +4 more

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

JCI Insight(2020)10.1172/jci.insight.142446

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35 citations

Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina Flint, Jil C. Tardiff +6 more

Controlling cardiac fibrosis through fibroblast state space modulation

Cellular Signalling(2020)10.1016/j.cellsig.2020.109888

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33 citations

Kalen Z. Robeson, Michael Regnier, Jennifer Davis, Isabella M. Reichardt

Multiscale modeling of twitch contractions in cardiac trabeculae

The Journal of General Physiology(2021)10.1085/jgp.202012604

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44 citations

Momčilo Prodanović, Corrado Poggesi, Michael A. Geeves, Michael Regnier, Srboljub M. Mijailovich

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Cell Reports(2021)10.1016/j.celrep.2021.109088

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22 citations

Dasom Yoo, Jennifer VanOudenhove, Yusheng Chen, Rachel Cohn, Feria A. Ladha +11 more

The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions

Journal of Molecular and Cellular Cardiology(2021)10.1016/j.yjmcc.2021.02.009

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21 citations

Momčilo Prodanović, Corrado Poggesi, Joseph D. Powers, Jennifer Davis, Michael A. Geeves +2 more

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101640

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70 citations

Kerry Y. Kao, Michael Regnier, Michael A. Geeves, Jonathan Walklate

Thick filament activation is different in fast‐ and slow‐twitch skeletal muscle

The Journal of Physiology(2022)10.1113/jp283574

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21 citations

Weikang Ma, Michael Regnier, Thomas C. Irving, Henry Gong

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

International Journal of Molecular Sciences(2022)10.3390/ijms23031135

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15 citations

Michael A. Geeves, Corrado Poggesi, Michael Regnier, Srboljub M. Mijailovich, Momčilo Prodanović

RETRACTED: dATP elevation induces myocardial metabolic remodeling to support improved cardiac function

Journal of Molecular and Cellular Cardiology(2022)10.1016/j.yjmcc.2022.11.010

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4 citations

Jason D. Murray, Galina Flint, Timothy S. McMillen, Gerhard Weber, Majid Shakeri +10 more

dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.07.515235

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1 citations

Jason D. Murray, Galina Flint, Timothy S. McMillen, Gerhard Weber, Majid Shakeri +10 more

Thick Filament Activation Is Different in Fast and Slow-Twitch Skeletal Muscle

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.09.499423

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0 citations

Weikang Ma, Michael Regnier, Thomas C. Irving, Henry Gong

Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2207615120

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60 citations

Timothy S. McMillen, Matthew C. Childers, Henry Gong, Michael Regnier, Thomas C. Irving +1 more

Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle

Circulation Research(2023)10.1161/circresaha.123.322629

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48 citations

Saffie Mohran, Kyrah L. Turner, Weikang Ma, Amy Martinson, Galina Flint +16 more

The biochemically defined super relaxed state of myosin—A paradox

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105565

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42 citations

Kristina B. Kooiker, Max Mahoney-Schaefer, Christian Mandrycky, Kerry Y. Kao, An-Yue Tu +5 more

Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects

Human Genetics and Genomics Advances(2023)10.1016/j.xhgg.2023.100213

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18 citations

Matthew C. Childers, Colby T. Marvin, Anthony J. Marcello, Hernán Gonorazky, Lili‐Naz Hazrati +13 more

Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2215836120

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14 citations

Shengjun You, Michael Regnier, J. Andrew McCammon, Wen Ma

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics(2023)10.1063/5.0157935

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5 citations

Abigail E. Teitgen, Kimberly J. McCabe, Sophia P. Hirakis, Gary Huber, Michael Regnier +4 more

Efficacy and muscle safety assessment of fukutin-related protein gene therapy

Molecular Therapy — Methods & Clinical Development(2023)10.1016/j.omtm.2023.05.022

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7 citations

Joseph W. Maricelli, Jane T. Seto, John K. Hall, Christine L. Halbert, Jacqueline Wicki +7 more

Incorporating Diversity, Equity, and Inclusion Content Into Bioengineering Curricula: A Program-Level Approach

Journal of Biomechanical Engineering(2023)10.1115/1.4063819

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3 citations

Emily Olszewski, Casey L. Kiyohara, Danafe D. Matusalem, Alexander Ochs, P. I. Imoukhuede +5 more

WITHDRAWN: Cell based dATP delivery as a therapy for chronic heart failure

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.24.538108

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6 citations

Julie Mathieu, Amy Martinson, Galina Flint, Leslie P. Blakley, Arash Tabesh +14 more

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.23.523684

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5 citations

Isabella M. Reichardt, Kristin A. Zabrecky, Alex J. Goldstein, Logan R.J. Bailey, Darrian Bugg +14 more

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.31.526380

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5 citations

Saffie Mohran, Kyrah L. Turner, Weikang Ma, Galina Flint, Lin Qi +16 more

MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.16.532974

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3 citations

Darrian Bugg, Isabella M. Reichardt, C. Dessirée Ortaç, Jagadambika Gunaje, Richard S. Johnson +6 more

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.08.544276

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2 citations

Alison Schroer Vander Roest, Cheavar A. Blair, Kerry Y. Kao, Samantha Bremner, Matthew C. Childers +19 more

Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects

medRxiv(2023)10.1101/2023.03.07.23286862

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0DataRank · unranked

0 citations

Matthew C. Childers, Colby T. Marvin, Anthony J. Marcello, Hernán Gonorazky, Lili‐Naz Hazrati +13 more

Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2318413121

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14 citations

Alison S. Vander Roest, Cheavar A. Blair, Kerry Y. Kao, Samantha Bremner, Matthew C. Childers +19 more

MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States

Circulation(2024)10.1161/circulationaha.123.066860

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20 citations

Darrian Bugg, Isabella M. Reichardt, C. Dessirée Ortaç, Abigail Nagle, Jagadambika Gunaje +8 more

Noncontractile Stem Cell-Cardiomyocytes Preserve Post-Infarction Heart Function

Circulation Research(2024)10.1161/circresaha.124.325133

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15 citations

Dasom Yoo, Amy Martinson, Xiulan Yang, Hans Reinecke, Michael Regnier +2 more

MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy

Journal of Molecular and Cellular Cardiology(2024)10.1016/j.yjmcc.2024.04.010

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14 citations

Saffie Mohran, Logan R.J. Bailey, Timothy S. McMillen, Kristina B. Kooiker, Neil B. Wood +8 more

Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways

GeroScience(2024)10.1007/s11357-024-01209-w

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13 citations

Renny S. Lan, Michael Regnier, Samuel G. Mackintosh, Ravinandan Venkatasubramanian, Dao‐Fu Dai +1 more

Calcium has a direct effect on thick filament activation in porcine myocardium

The Journal of General Physiology(2024)10.1085/jgp.202413545

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9 citations

Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian +7 more

Interacting myosin head dynamics and their modification by 2′-deoxy-ADP

Biophysical Journal(2024)10.1016/j.bpj.2024.10.013

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8 citations

Michael A. Geeves, Michael Regnier, Matthew C. Childers

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

The Journal of General Physiology(2024)10.1085/jgp.202413538

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8 citations

Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman +1 more

The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+]

The Journal of Physiology(2024)10.1113/jp286802

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5 citations

Blake J. Vander Top, Kristina B. Kooiker, Saffie Mohran, Christian Mandrycky, Timothy S. McMillen +5 more

Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor

The Journal of General Physiology(2024)10.1085/jgp.202313503

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3 citations

Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng +11 more

Dynamics of the Pre-Powerstroke Myosin Lever Arm and the Effects of Omecamtiv Mecarbil

International Journal of Molecular Sciences(2024)10.3390/ijms251910425

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2 citations

Michael Regnier, Matthew C. Childers

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.29.582851

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10 citations

Debanjan Bhowmik, Matthew C. Childers, Rama Reddy Goluguri, Aminah Dawood, Michael Regnier +3 more

Far-red and sensitive sensor for monitoring real time H 2 O 2 dynamics with subcellular resolution and in multi-parametric imaging applications

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.06.579232

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6 citations

Amanda Nguyen, Z. Jin, Aida Moghadasi, Chelsea E. Gibbs, Sarah J. Wait +14 more

Far-red and sensitive sensor for monitoring real time H2O2 dynamics with subcellular resolution and in multi-parametric imaging applications.

Research Square(2024)10.21203/rs.3.rs-3974015/v1

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1 citations

Justin Daho Lee, Amanda Nguyen, Z. Jin, Aida Moghadasi, Chelsea E Gibbs +15 more

An atomistic model of myosin interacting heads motif dynamics and their modification by 2’-deoxy-ADP

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.06.597809

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1 citations

Michael A. Geeves, Michael Regnier, Matthew C. Childers

MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient-induced stem cell-derived cardiomyocyte model of hypertrophic cardiomyopathy

Biophysical Journal(2024)10.1016/j.bpj.2023.11.1955

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0 citations

Saffie Mohran, Logan R.J. Bailey, Timothy S. McMillen, Kristina B. Kooiker, Neil B. Wood +8 more

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy

Science(2025)10.1126/science.adv9157

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9 citations

Isabella M. Reichardt, Kristin A. Zabrecky, Abigail Nagle, Logan R.J. Bailey, Darrian Bugg +17 more

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity

The Journal of General Physiology(2025)10.1085/jgp.202413628

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8 citations

Sonette Steczina, Ateeqa Naim, Michael Regnier, Michael A. Geeves, Neil M. Kad +1 more

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

Journal of Molecular and Cellular Cardiology(2025)10.1016/j.yjmcc.2025.10.008

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2 citations

Saffie Mohran, Matthew C. Childers, Timothy S. McMillen, Ateeqa Naim, Matvey Pilagov +14 more

Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms

Archives of Biochemistry and Biophysics(2025)10.1016/j.abb.2025.110380

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1 citations

Michael J. Rynkiewicz, Wen Jian, An-Yue Tu, Michael Regnier, William Lehman +2 more

Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin’s biochemical activity without changing thick filament structure

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.14.654110

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3 citations

Kristina B. Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Kyrah L. Turner +13 more

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.27.672708

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3 citations

Saffie Mohran, Matthew C. Childers, Timothy S. McMillen, Ateeqa Naim, Matvey Pilagov +14 more

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)(2025)10.1101/2025.05.08.652664

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0 citations

Marica Dente, Weikang Ma, Beatrice Scellini, Nicoletta Piroddi, Marina Scardigli +12 more

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Biophysical Journal(2020)10.1016/j.bpj.2020.07.006

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56 citations

Elumalai Pavadai, Michael J. Rynkiewicz, Jonathan Walklate, Esther Bullitt, Jeffrey R. Moore +4 more

Functional interrogation of contextually correct MYH7 variants using CRaTER-flox gene editing and contractility profiling

Journal of Clinical Investigation(2025)10.1172/jci192057

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0 citations

Wei‐Ming Chien, Ashley Mckinstry, Dania Ahmed, Matthew C. Childers, Michael Regnier +3 more