Tyler S. Beyett

MedicineBiochemistry, Genetics and Molecular BiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 31 papers. Top paper: “Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors”.

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Nature Communications(2022)10.1038/s41467-022-30258-y

N/A

2.0DataRank · unranked

88 citations

Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang +7 more

Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00848

N/A

1.3DataRank · unranked

45 citations

David E. Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K. Rana +13 more

Oncogenic K-Ras suppresses global miRNA function

Molecular Cell(2023)10.1016/j.molcel.2023.06.008

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0.442DataRank · unranked

18 citations

Tyler S. Beyett, Zhengyi Chen, Xiaoyi Li, Gaspare La Rocca, William Gazlay +5 more

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c01891

N/A

0.241DataRank · unranked

4 citations

Wenchao Lu, Tyler S. Beyett, Scott B. Ficarro, Jie Jiang, Jason Tse +8 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-cs3xn-v2

N/A

0.208DataRank · unranked

3 citations

Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner +15 more

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Cancer Research(2022)10.1158/0008-5472.can-21-2693

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0DataRank · unranked

36 citations

Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano +13 more

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128718

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0DataRank · unranked

23 citations

David E. Heppner, Tyler S. Beyett, Ciric To, Seth C. Azevedo, Jaebong Jang +11 more

Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.27.505540

N/A

0DataRank · unranked

5 citations

Jaimin K. Rana, Ilse K. Schaeffner, David E. Heppner, Michael J. Eck, Tyler S. Beyett

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ChemRxiv(2022)10.26434/chemrxiv-2022-5m8h5-v2

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0DataRank · unranked

3 citations

Tyler S. Beyett, Tatiana Shaurova, Calvin Pham, Florian Wittlinger, Ilse K. Schaeffner +6 more

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ChemRxiv(2022)10.26434/chemrxiv-2022-5m8h5

N/A

0DataRank · unranked

0 citations

Tyler S. Beyett, Tatiana Shaurova, Calvin Pham, Florian Wittlinger, Ilse K. Schaeffner +6 more

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104634

N/A

0DataRank · unranked

70 citations

Kunhua Li, Gonzalo L. González‐Del Pino, Byung Hak Ha, Javier Viñals, Eunyoung Park +3 more

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors

Methods in enzymology on CD-ROM/Methods in enzymology(2023)10.1016/bs.mie.2023.03.013

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0DataRank · unranked

8 citations

Florian Wittlinger, Tyler S. Beyett, Michael J. Eck, Stefan Laufer, David E. Heppner +1 more

Development of Mutant-Selective Allosteric EGFR Inhibitors for Drug-Resistant Lung Cancer

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.162040

N/A

0DataRank · unranked

1 citations

Ciric To, David E. Heppner, Thomas W. Gero, Nathanael S. Gray, David A. Scott +3 more

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

Molecular Pharmacology(2023)10.1124/molpharm.123.000768

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0DataRank · unranked

2 citations

Ilse K. Schaeffner, David E. Heppner, Ciric To, Pasi A. Jänne, Tyler S. Beyett +2 more

Examining molecular factors of inactive versus active bivalent EGFR inhibitors: A missing link in fragment-based drug design.

ChemRxiv(2023)10.26434/chemrxiv-2023-cs3xn

N/A

0DataRank · unranked

3 citations

Blessing C. Ogboo, Calvin D. Pham, Ilse K. Schaeffner, Surbhi P. Chitnis, Tahereh Damghani +12 more

The origin of potency and mutant-selective inhibition by bivalent ATP-allosteric EGFR inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-zzfc3

N/A

0DataRank · unranked

2 citations

Surbhi P. Chitnis, Calvin D Pham, Tahereh Damghani, Ilse K. Schaeffner, Matthew Q. Deng +13 more

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.

ChemRxiv(2023)10.26434/chemrxiv-2023-v522v

N/A

0DataRank · unranked

0 citations

Florian Wittlinger, Tyler S. Beyett, Michael J. Eck, Stefan Laufer, David E. Heppner +1 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Research Square(2023)10.21203/rs.3.rs-3286949/v1

N/A

0DataRank · unranked

0 citations

Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin Pham +15 more

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Communications Chemistry(2024)10.1038/s42004-024-01108-3

N/A

0DataRank · unranked

24 citations

Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner +15 more

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

ACS Central Science(2024)10.1021/acscentsci.3c01245

N/A

0DataRank · unranked

15 citations

Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares +9 more

Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase

ChemMedChem(2024)10.1002/cmdc.202300343

N/A

0DataRank · unranked

10 citations

Jaimin K. Rana, Ilse K. Schaeffner, David E. Heppner, Michael J. Eck, Tyler S. Beyett

Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent “Type V” Kinase Inhibitors

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c02311

N/A

0DataRank · unranked

8 citations

Surbhi P. Chitnis, Calvin D. Pham, Tahereh Damghani, Kishan B. Patel, Mareike Möllers +17 more

Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2417144121

N/A

0DataRank · unranked

5 citations

Tyler S. Beyett, Jie Jiang, Jaimin K. Rana, Ilse K. Schaeffner, J. A. da S. Santana +3 more

Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer’s Disease

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01425

N/A

0DataRank · unranked

1 citations

Andrew Li, Payton Fleming, Julia Gralla, Kristos Negrón Terón, Ying Zhou +7 more

Enantioselective protein affinity selection mass spectrometry (E-ASMS)

Nature Communications(2025)10.1038/s41467-025-67403-2

N/A

0DataRank · unranked

1 citations

Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, U Hang Chan +34 more

Molecular Design of a “Two-in-One” Orthosteric-Allosteric Chimeric Mutant Selective EGFR Inhibitor

ChemRxiv(2020)10.26434/chemrxiv.13416452

N/A

0DataRank · unranked

1 citations

david heppner, Ciric To, Marcel C. Guenther, Bo Hee Shin, Jaimin K Rana +6 more

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.17.633682

N/A

0DataRank · unranked

7 citations

Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, U Hang Chan +33 more

Molecular Design of a “Two-in-One” Orthosteric-Allosteric Chimeric Mutant Selective EGFR Inhibitor

(2020)10.26434/chemrxiv.13416452.v1

N/A

0DataRank · unranked

0 citations

David E. Heppner, Ciric To, Marcel C. Guenther, Bo Hee Shin, Jaimin K Rana +6 more

Biochemical characterization of the interaction between KRAS and Argonaute 2

Biochemistry and Biophysics Reports(2021)10.1016/j.bbrep.2021.101191

N/A

0DataRank · unranked

8 citations

Tyler S. Beyett, Varun V. Gadkari, Ronald F. Siebenaler, Carson Kenum, Sunita Shankar +4 more

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Nature Cancer(2022)10.1038/s43018-022-00351-8

N/A

0DataRank · unranked

163 citations

Tyler S. Beyett, Jaebong Jang, William W. Feng, Magda Bahcall, Heidi M. Haikala +21 more

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01041

N/A

0DataRank · unranked

31 citations

Tyler S. Beyett, William W. Feng, Andreas Krämer, Janik Weckesser, Ilse K. Schaeffner +6 more