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Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase

ChemMedChem(2024)10.1002/cmdc.202300343Source: DataRank Database

Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase is a research paper published in ChemMedChem (2024). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (22 grants)Topics (25)IDs (PubMed, PMC)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Jaimin K. Rana,Ilse K. Schaeffner,David E. Heppner ORCID,Michael J. Eck ORCID,Tyler S. Beyett ORCID

Live enrichment

PubMed:38523074 PMC:PMC11212799

National Institutes of Health

Grant: RO1 CA201049

National Institutes of Health

Grant: PO1 CA154303

National Institutes of Health

Grant: R35 CA242461

NCI NIH HHS

Grant: F32 CA247198

Nathanael Gray

Grant: BI-4020

Ruth L. Kirschstein National Research Service Award

Grant: F32CA247198-01

Northeastern Collaborative Access Team beamlines

Grant: P30GM124165

NIH-ORIP HEI grant

Grant: S10OD021527

National Center for Advancing Translational Sciences of the NIH

Grant: UL1TR001412-07

NIGMS NIH HHS

Grant: P41 GM103403

Advanced Photon Source at the Argonne National Laboratory

Grant: DE-AC02-06CH11357

NCI NIH HHS

Grant: P01 CA154303

NCI NIH HHS

Grant: R01 CA201049

NCATS NIH HHS

Grant: UL1 TR001412

National Institutes of Health

Grant: 5R35CA242461-04

Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway

National Institutes of Health

Grant: 5P41GM103403-15

NE-CAT Center for Advanced Macromolecular Crystallography

National Institutes of Health

Grant: 5P01CA154303-09

Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma

National Institutes of Health

Grant: 3P30GM124165-03S1

NE-CAT: A Resource for Advanced Macromolecular Crystallography

National Institutes of Health

Grant: 5F32CA247198-03

Studies of mutant-selective allosteric inhibitors of EGFR for non-small cell lung cancer

National Institutes of Health

Grant: 3UL1TR001412-08S3

Buffalo Clinical and Translational Research Center

National Institutes of Health

Grant: 2R01CA201049-06

Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M

National Institutes of Health

Grant: 1S10OD021527-01

Pixel Array Detector for Macromolecular Crystallography

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

HumansMacrocyclic CompoundsAntineoplastic AgentsProtein Kinase InhibitorsCrystallography, X-RayBinding SitesMolecular StructureStructure-Activity RelationshipDose-Response Relationship, DrugModels, MolecularErbB Receptors

Keywords

Models, MolecularMacrocyclic CompoundsBinding SitesMolecular StructureDose-Response Relationship, DrugAntineoplastic AgentsCrystallography, X-RayErbB ReceptorsStructure-Activity RelationshipHumansProtein Kinase Inhibitors

Sustainable Development Goals

SDG 3: 3. Good health