Jack F. Shern

Also affiliated with National Institutes of Health, Dana-Farber Cancer Institute, Center for Cancers and Blood Disorders, National Cancer Institute, Center for Cancer Research

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 44 papers. Top paper: “Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression”.

Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression

Cell stem cell(2021)10.1016/j.stem.2021.04.029

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1.3DataRank · unranked

43 citations

Xuanhua Xie, Xiyuan Zhang, Zilai Wang, Sameer Farouk Sait, Swathi V. Iyer +7 more

Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial

Nature Medicine(2025)10.1038/s41591-024-03361-4

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0.954DataRank · unranked

41 citations

Geraldine O’Sullivan Coyne, Eva Dombi, Cecilia Tibery, William G. Herrick, Staci Martin +30 more

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study

PLoS Medicine(2021)10.1371/journal.pmed.1003734

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0.665DataRank · unranked

83 citations

R. Taylor Sundby, Paul A. Jones, Divya Srihari, Noah Earland, Peter K. Harris +16 more

Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-0709

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0.652DataRank · unranked

20 citations

R. Taylor Sundby, Donna Bernstein, John Glod, Rosandra N. Kaplan, Marielle E. Yohe +17 more

Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group

Scientific Reports(2020)10.1038/s41598-020-69015-w

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0.581DataRank · unranked

47 citations

Valentin Dinu, Xiyuan Zhang, Haiyan Lei, Jack F. Shern, Jin Hyoung Park +10 more

Protocol for using single-cell sequencing to study the heterogeneity of NF1 nerve sheath tumors from clinical biospecimens

STAR Protocols(2023)10.1016/j.xpro.2023.102297

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0.269DataRank · unranked

5 citations

Vishaka Gopalan, Neeraja Syed, Sridhar Hannenhalli, Jack F. Shern, Xiyuan Zhang

Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics

medRxiv(2024)10.1101/2024.01.18.24301053

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0.208DataRank · unranked

3 citations

Jeffrey J. Szymanski, Alexander Pan, Paul A. Jones, Sana Mahmood, Olivia H. Reid +24 more

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: a cross-sectional study

medRxiv(2021)10.1101/2021.04.22.21255769

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0DataRank · unranked

19 citations

R. Taylor Sundby, Paul A. Jones, Divya Srihari, Noah Earland, Peter K. Harris +16 more

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

JCI Insight(2022)10.1172/jci.insight.154513

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0DataRank · unranked

65 citations

Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa R. Perrino, Nathan Salomonis +3 more

Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-0717

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0DataRank · unranked

31 citations

Xiyuan Zhang, Ming Sun, Shahroze Abbas, Charlie Seibert, Michael C. Kelly +3 more

Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-1663

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0DataRank · unranked

28 citations

Hyun Jung, G. Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle +20 more

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Cell Reports(2022)10.1016/j.celrep.2022.111363

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0DataRank · unranked

27 citations

Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda Jafarah, Haiyan Lei +10 more

The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-1646

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0DataRank · unranked

21 citations

Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye +29 more

Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry

Cell Death and Disease(2022)10.1038/s41419-022-05314-6

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0DataRank · unranked

6 citations

Xiyuan Zhang, Man Xu, Haiyan Lei, Jack F. Shern, Carol J. Thiele +1 more

A “ cooperative collaboration ” between HAND2 and MYCN shapes neuroblastoma cell identity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.18.492511

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0DataRank · unranked

1 citations

Ming Sun, Xiyuan Zhang, Rosa Nguyen, Haiyan Lei, Jack F. Shern +3 more

KDM3B inhibitors disrupt PAX3-FOXO1 oncogenic activity in fusion positive rhabdomyosarcoma.

Research Square(2022)10.21203/rs.3.rs-2298627/v1

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0DataRank · unranked

0 citations

Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud +26 more

Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-1872

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0DataRank · unranked

40 citations

Ekaterina Doubrovina, Charlotte M. Mousset, Benjamin Y. Jin, Reona Okada, Xiyuan Zhang +13 more

HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype

Cancer Research(2023)10.1158/0008-5472.can-22-2042

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0DataRank · unranked

21 citations

Ming Sun, Xiyuan Zhang, Rosa Nguyen, Haiyan Lei, Jack F. Shern +3 more

Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-0200

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0DataRank · unranked

13 citations

Victor J. Collins, Choh Yeung, Takeshi Itoh, Sameer H. Issaq, David O. Holland +16 more

MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.11.548643

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0DataRank · unranked

3 citations

Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei +3 more

Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

(2023)10.1158/0008-5472.22422704

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0DataRank · unranked

0 citations

Anna E. Gibson, Sameer H. Issaq, Nobu Oshima, Joshua T. Baumgart, Leah D. Edessa +23 more

Data from Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group

(2023)10.1158/1078-0432.c.6532878.v1

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0DataRank · unranked

0 citations

Hyun Jung, G. Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle +20 more

Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Figshare(2023)10.1158/0008-5472.22422704.v1

N/A

0DataRank · unranked

0 citations

Anna E. Gibson, Sameer H. Issaq, Nobu Oshima, Joshua T. Baumgart, Leah D. Edessa +23 more

Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

Clinical Cancer Research(2024)10.1158/1078-0432.ccr-24-0797

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0DataRank · unranked

22 citations

Jeffrey J. Szymanski, Alexander Pan, Paul A. Jones, Sana Mahmood, Olivia H. Reid +24 more

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Nature Communications(2024)10.1038/s41467-024-45902-y

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0DataRank · unranked

18 citations

Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud +27 more

Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma

JAMA Network Open(2024)10.1001/jamanetworkopen.2024.4170

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0DataRank · unranked

13 citations

He Li, Michael E. Scheurer, Dana L. Casey, Shannon Dugan‐Perez, Deborah A. Marquez-Do +19 more

MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription

PLoS Biology(2024)10.1371/journal.pbio.3002240

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0DataRank · unranked

12 citations

Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei +3 more

Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity

The EMBO Journal(2024)10.1038/s44318-024-00206-1

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0DataRank · unranked

8 citations

Jason J Hong, Xiyuan Zhang, Ming Sun, Xingyu Liu, Jeeyoun Kang +11 more

Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma

Cancers(2024)10.3390/cancers16132320

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0DataRank · unranked

6 citations

Jacob S. Roth, Edjay R. Hernandez, Joshua T. Kowalczyk, Nancy E. Sealover, Katie E. Hebron +17 more

ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity

Molecular Cancer Research(2024)10.1158/1541-7786.mcr-24-0490

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0DataRank · unranked

3 citations

Olivia L. Perkins, Angela Kim, Xiaoying Jian, Sofia A. Girald-Berlingeri, Haiyan Lei +5 more

Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma

UNC Libraries(2024)10.17615/m7sp-3e70

N/A

0DataRank · unranked

0 citations

Shannon Dugan‐Perez, Michael E. Scheurer, Sharon E. Plon, Brian D. Crompton, Philip J. Lupo +19 more

GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma

Cancer Immunology Research(2025)10.1158/2326-6066.cir-24-0975

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0DataRank · unranked

9 citations

Jeyshka M. Reyes‐González, Constanza Rodríguez, Taisuke Kondo, Jangsuk Oh, Ming Sun +10 more

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

Oncogenesis(2025)10.1038/s41389-025-00557-2

N/A

0DataRank · unranked

6 citations

Jason J Hong, Xiyuan Zhang, Carly M. Sayers, Wendy Fang, Man Xu +9 more

Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer

Molecular Cancer Therapeutics(2025)10.1158/1535-7163.mct-25-0022

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0DataRank · unranked

2 citations

Stacey Stauffer, Hyun Lee, Kristine A. Isanogle, Ying Wu, Katie Powell +17 more

Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children’s Oncology Group

European Journal of Cancer(2025)10.1016/j.ejca.2025.115600

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0DataRank · unranked

1 citations

David P. Douglass, Sapna Oberoi, Natalie B. Collins, Ajay Gupta, Jonathan Metts +17 more

The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children’s Oncology Group

Human Genetics and Genomics Advances(2025)10.1016/j.xhgg.2025.100466

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0DataRank · unranked

0 citations

Christina L. Magyar, Bailey A. Martin‐Giacalone, Michael E. Scheurer, Deborah A. Marquez-Do, Mark Zobeck +17 more

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

Journal of Clinical Investigation(2020)10.1172/jci130059

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0DataRank · unranked

70 citations

Marie Pouzolles, Christopher D. Chien, Rebecca Erwin-Cohen, M. Eric Kohler, Haiying Qin +16 more

The prostate is a common site of disease in patients with MEN2B and medullary thyroid carcinoma

Endocrine Related Cancer(2025)10.1530/erc-24-0243

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0DataRank · unranked

0 citations

Srivandana Akshintala, Andrea M. Gross, Eva Dombi, Barış Türkbey, Sandra Bednarova +9 more

Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy

Leukemia(2020)10.1038/s41375-020-0760-x

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0DataRank · unranked

45 citations

Constance M. Yuan, Katherine E. Masih, Pallavi Galera, Dalia Salem, Haneen Shalabi +8 more

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor

Genes(2020)10.3390/genes11030287

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0DataRank · unranked

41 citations

Béga Murray, George Mo, Jack F. Shern, Xiyuan Zhang

Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia

Journal for ImmunoTherapy of Cancer(2020)10.1136/jitc-2020-001563

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0DataRank · unranked

31 citations

Hao‐Wei Wang, Aimee C. Talleur, Shilpa Shahani, Bonnie Yates, Haneen Shalabi +13 more

Immuno-transcriptomic profiling of extracranial pediatric solid malignancies

Cell Reports(2021)10.1016/j.celrep.2021.110047

N/A

0DataRank · unranked

74 citations

Sivasish Sindiri, Jun S. Wei, David Milewski, Hsien-Chao Chou, Young C. Song +32 more

Liquid biopsies in pediatric oncology: opportunities and obstacles

Current Opinion in Pediatrics(2021)10.1097/mop.0000000000001088

N/A

0DataRank · unranked

26 citations

Alexander Pan, Jack F. Shern, R. Taylor Sundby

Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification

Journal of Clinical Investigation(2021)10.1172/jci138022

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0DataRank · unranked

26 citations

Prasantha L. Vemu, Gregory Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern +4 more