Andrew A. Pieper

Also affiliated with Discovery Institute, University Hospitals Cleveland Medical Center, Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center, University School, Case Western Reserve University

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 50 papers. Top paper: “Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease”.

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

Nature Aging(2021)10.1038/s43587-021-00138-z

N/A

0.800DataRank · unranked

206 citations

Pengyue Zhang, Yadi Zhou, Chien‐Wei Chiang, Juan Tan, Yuan Hou +6 more

Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer’s disease

Cell Reports(2022)10.1016/j.celrep.2022.111717

N/A

0.702DataRank · unranked

107 citations

Chengsheng Mao, Yuan Hou, Yuan Luo, Jessica Binder, Yadi Zhou +12 more

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery

Alzheimer s Research & Therapy(2021)10.1186/s13195-020-00760-w

N/A

0.673DataRank · unranked

88 citations

Jiansong Fang, Lynn M. Bekris, Young Heon Kim, Andrew A. Pieper, James B. Leverenz +3 more

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Alzheimer s Research & Therapy(2022)10.1186/s13195-022-01151-z

N/A

0.546DataRank · unranked

37 citations

Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin +8 more

Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution

Cell Reports(2024)10.1016/j.celrep.2024.114911

N/A

0.529DataRank · unranked

18 citations

Alice Chaplin, Lin Di, Anastasia Ravodina, Graham H. Bevan, Huiyun Gao +10 more

Network medicine informed multiomics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis

npj Systems Biology and Applications(2024)10.1038/s41540-024-00449-y

N/A

0.385DataRank · unranked

12 citations

Jielin Xu, Ranjan Dutta, Bruce Trapp, Andrew A. Pieper, Feixiong Cheng +1 more

Single-nucleus multiome analysis of human cerebellum in Alzheimer’s disease-related dementia

Research Square(2024)10.21203/rs.3.rs-4871032/v1

N/A

0.241DataRank · unranked

4 citations

Yayan Feng, Margaret E. Flanagan, Borna Bonakdarpour, Pouya Jamshidi, Rudolph J. Castellani +12 more

Combining genetics with real-world patient data enables ancestry-specific target identification and drug discovery in Alzheimer’s disease

Research Square(2025)10.21203/rs.3.rs-5716817/v1

N/A

0.208DataRank · unranked

3 citations

Yuan Hou, Pengyue Zhang, Yi‐Chen Li, Noah Lorincz‐Comi, Fan Fan +27 more

Population‐based discovery and Mendelian randomization analysis identify telmisartan as a candidate medicine for Alzheimer's disease in African Americans

Alzheimer s & Dementia(2022)10.1002/alz.12819

N/A

0DataRank · unranked

26 citations

Yuan Hou, Wanzhu Tu, Noll L. Campbell, Andrew A. Pieper, James B. Leverenz +4 more

A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease

Acta Neuropathologica(2022)10.1007/s00401-022-02499-0

N/A

0DataRank · unranked

14 citations

Xiaoyan Sun, Xiaoqin Chen, QuanQiu Wang, Evan J. Wang, Emiko Miller +4 more

CYP46A1 Activation By Low-Dose Efavirenz Enhances Brain Cholesterol Metabolism In Subjects With Mild Cognitive Impairment Due To Alzheimer’s Disease

Research Square(2022)10.21203/rs.3.rs-1348328/v1

N/A

0DataRank · unranked

0 citations

Steven E. Arnold, Erin Maxfield, Aaron Koenig, Mária Tóth, Brooke Fortin +8 more

Hydrogen sulfide signalling in neurodegenerative diseases

British Journal of Pharmacology(2023)10.1111/bph.16170

N/A

0DataRank · unranked

57 citations

Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul, Sunil Jamuna Tripathi

Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury

Biomedicines(2023)10.3390/biomedicines11041154

N/A

0DataRank · unranked

52 citations

Bindu D. Paul, Andrew A. Pieper, Sarah Barker

Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease

Alzheimer s & Dementia(2023)10.1002/alz.13546

N/A

0DataRank · unranked

22 citations

Jessica Caldwell, Justin D. Lathia, James B. Leverenz, Andrew A. Pieper, Jeffrey L. Cummings +2 more

Slingshot homolog-1–mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer’s disease

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217128120

N/A

0DataRank · unranked

21 citations

Jung A. Woo, Xinming Wang, Tian Liu, Shanon Rego, Teresa R. Kee +5 more

Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury

Neurotherapeutics(2023)10.1007/s13311-023-01427-8

N/A

0DataRank · unranked

17 citations

Emiko Miller, Andrew A. Pieper, Preethy Sridharan

Longitudinal in vivo monitoring of axonal degeneration after brain injury

Cell Reports Methods(2023)10.1016/j.crmeth.2023.100481

N/A

0DataRank · unranked

10 citations

Julie Borovicka, Davina Patel, Min‐Kyoo Shin, Edwin Vázquez‐Rosa, Emiko Miller +4 more

Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer’s disease

Cell Reports Medicine(2024)10.1016/j.xcrm.2023.101379

N/A

0DataRank · unranked

57 citations

Fei Wang, Jian Tang, Yadi Zhou, Zhimin Fu, Pengyue Zhang +8 more

Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease

Cell Reports(2024)10.1016/j.celrep.2024.114128

N/A

0DataRank · unranked

34 citations

Yuan Hou, Dhruv Gohel, Yadi Zhou, Jielin Xu, Marina Bykova +8 more

Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease

Current Opinion in Chemical Biology(2024)10.1016/j.cbpa.2024.102511

N/A

0DataRank · unranked

33 citations

Andrew A. Pieper, Bindu D. Paul

Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury

Cell Reports Medicine(2024)10.1016/j.xcrm.2024.101715

N/A

0DataRank · unranked

32 citations

Yeojung Koh, Emiko Miller, Di Hu, Suwarna Chakraborty, Sunil Jamuna Tripathi +24 more

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Science Advances(2020)10.1126/sciadv.abb8680

N/A

0DataRank · unranked

193 citations

Rihua Wang, Di Hu, Xiaoyan Sun, Hisashi Fujioka, Kathleen C. Lundberg +7 more

Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons

Journal of Alzheimer s Disease(2024)10.3233/jad-231391

N/A

0DataRank · unranked

18 citations

Pengyue Zhang, Amit Gupta, Yi‐Chen Li, Chien‐Wei Chiang, Lang Li +5 more

Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Biomolecules(2024)10.3390/biom14020155

N/A

0DataRank · unranked

20 citations

Andrew A. Pieper, Bindu D. Paul

Single‐microglia transcriptomic transition network‐based prediction and real‐world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.14373

N/A

0DataRank · unranked

13 citations

Wenqiang Song, Zhenxing Xu, Michael M. Danziger, Ehud Karavani, Chengxi Zang +16 more

Elevated Autoantibodies to the GluA1 Subunit of the AMPA Receptor in Blood Indicate Risk of Cognitive Impairment in Contact Sports Athletes, Irrespective of Concussion

Neurotrauma Reports(2024)10.1089/neur.2023.0132

N/A

0DataRank · unranked

1 citations

D Soden, Joseph C. Maroon, Warren R. Selman, Christopher Tangen, John Gunstad +5 more

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

Research Square(2024)10.21203/rs.3.rs-4869009/v1

N/A

0DataRank · unranked

0 citations

Lijun Dou, Zhigang Xu, Jielin Xu, Chang Su, Andrew A. Pieper +5 more

Real‐world observations of GLP‐1 receptor agonists and SGLT‐2 inhibitors as potential treatments for Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.70639

N/A

0DataRank · unranked

16 citations

Chengsheng Mao, Anna Sun, Yuedi Yang, Yuan Hou, Zhimin Fu +7 more

Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00586

N/A

0DataRank · unranked

13 citations

Sudarshana M. Sharma, Andrew A. Pieper, Bindu D. Paul, Bobby Thomas, Priyanka Soni

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

npj Parkinson s Disease(2025)10.1038/s41531-025-00870-y

N/A

0DataRank · unranked

10 citations

Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper +6 more

Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

Cell Reports Medicine(2025)10.1016/j.xcrm.2025.102535

N/A

0DataRank · unranked

10 citations

Edwin Vázquez-Rosa, Sunil Jamuna Tripathi, Min-Kyoo Shin, Youngmin Yu, Matasha Dhar +31 more

Human herpesvirus‐associated transposable element activation in human aging brains with Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.14595

N/A

0DataRank · unranked

13 citations

Shuqin Cao, Yi Shi, Anna Sun, Margaret E. Flanagan, James B. Leverenz +7 more

Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2528478122

N/A

0DataRank · unranked

5 citations

Sunil Jamuna Tripathi, Edwin Vázquez-Rosa, Kalyani Chaubey, Hisashi Fujioka, Emiko Miller +12 more

Cystic Fibrosis-related neurodegenerative disease associated with tauopathy and cognitive decline in aged CF mice

Journal of Cystic Fibrosis(2025)10.1016/j.jcf.2025.04.003

N/A

0DataRank · unranked

3 citations

Xinming Wang, Sarah Barker, Deborah A. Corey, Edwin Vázquez‐Rosa, Nichele Abeyesundere +7 more

15-PGDH inhibition enhances hematopoietic regeneration during aging

Stem Cells(2025)10.1093/stmcls/sxaf047

N/A

0DataRank · unranked

2 citations

Brittany A Cordova, Hong Ma, Bailey R Klein, Lyannah A Contreras, Ritisha Rashmil +7 more

Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders

Handbook of experimental pharmacology(2025)10.1007/164_2025_757

N/A

0DataRank · unranked

1 citations

Bindu D. Paul, Andrew A. Pieper

Synergistic mitochondrial impairment by endogenously elevated cyanide and hydrogen sulfide in Down syndrome; commentary on: Cyanide overproduction impairs cellular bioenergetics in Down syndrome

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00757

N/A

0DataRank · unranked

2 citations

Bindu D. Paul, Andrew A. Pieper

15-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during aging

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.11.648417

N/A

0DataRank · unranked

1 citations

Brittany Cordova, Hong Ma, Bailey Klein, Lyannah A. Contreras, Ritisha Rashmil +7 more

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.04.657936

N/A

0DataRank · unranked

0 citations

Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S. Dhindsa +16 more

Erratum to ‘Utilization of precision medicine digital twins for drug discovery in Alzheimer's disease’, Neurotherapeutics, 22(3), e00553

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00628

N/A

0DataRank · unranked

0 citations

Andrew A. Pieper, Feixiong Cheng, Yunxiao Ren

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

Research Square(2025)10.21203/rs.3.rs-7207381/v1

N/A

0DataRank · unranked

0 citations

Yunguang Qiu, Yuan Hou, Liam Wetzel Wetzel, Jessica Caldwell, Xiongwei Zhu +3 more

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer s & Dementia Translational Research & Clinical Interventions(2025)10.1002/trc2.70193

N/A

0DataRank · unranked

0 citations

Ehud Karavani, Michael M. Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou +6 more

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Molecular Neurodegeneration(2024)10.1186/s13024-024-00733-9

N/A

0DataRank · unranked

22 citations

Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan +13 more

Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing

Medicinal Research Reviews(2020)10.1002/med.21709

N/A

0DataRank · unranked

96 citations

Andrew A. Pieper, Ruth Nussinov, Garam Lee, Lynn M. Bekris, James B. Leverenz +3 more

Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer’s Disease

medRxiv(2020)10.1101/2020.01.15.20017160

N/A

0DataRank · unranked

15 citations

Pengyue Zhang, Quan Wang, Yadi Zhou, Chien‐Wei Chiang, Rui Chen +8 more

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.23.310466

N/A

0DataRank · unranked

13 citations

Pengyue Zhang, Yin Huang, Lynn M. Bekris, Justin D. Lathia, Chien‐Wei Chiang +6 more

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer’s Therapeutic Discovery

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.17.302612

N/A

0DataRank · unranked

0 citations

Jiansong Fang, Lynn M. Bekris, Young Heon Kim, Andrew A. Pieper, James B. Leverenz +3 more

A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.06.322883

N/A

0DataRank · unranked

0 citations

Calvin S. Carter, Qihong Zhang, Sunny C. Huang, Charles Searby, Ying Hsu +11 more

Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

Genome Research(2021)10.1101/gr.272484.120

N/A

0DataRank · unranked

82 citations

Pengyue Zhang, Yin Huang, Yadi Zhou, Yuan Hou, Lynn M. Bekris +8 more

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease

Alzheimer s Research & Therapy(2022)10.1186/s13195-021-00951-z

N/A

0DataRank · unranked

121 citations

Pengyue Zhang, Quan Wang, Chien‐Wei Chiang, Yadi Zhou, Yuan Hou +11 more