Taosheng Chen

Pharmacology, Toxicology and PharmaceuticsMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 7%percentile

0.123Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.06.407973

Top 71%

0.123DataRank

Top 71%1 citations

Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin +34 more

Papers

Driven by 51 papers — median percentile 29. Top paper: “Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases”.

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Nature Communications(2020)10.1038/s41467-020-18708-x

N/A

0.985DataRank · unranked

26 citations

Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari +10 more

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

Nature Communications(2021)10.1038/s41467-021-24168-8

N/A

0.624DataRank · unranked

63 citations

Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin +35 more

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Drug Metabolism and Disposition(2022)10.1124/dmd.122.000858

N/A

0.553DataRank · unranked

39 citations

Andrew D. Huber, Taosheng Chen, Shyaron Poudel

Regulation of PXR in drug metabolism: chemical and structural perspectives

Expert Opinion on Drug Metabolism & Toxicology(2024)10.1080/17425255.2024.2309212

N/A

0.500DataRank · unranked

27 citations

Andrew D. Huber, Taosheng Chen, Rebecca R. Florke Gee

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2

Nature Communications(2024)10.1038/s41467-024-52966-3

N/A

0.494DataRank · unranked

26 citations

Suresh Dharuman, Elizabeth C. Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King +17 more

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Clinical and Translational Science(2021)10.1111/cts.13012

N/A

0.434DataRank · unranked

17 citations

Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang +23 more

17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

iScience(2020)10.1016/j.isci.2020.101996

N/A

0.425DataRank · unranked

16 citations

Ahmed Abu‐Zaid, Wenwei Lin, Jonathan Low, Alireza Abdolvahabi, Hongjian Jin +24 more

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure(2023)10.1016/j.str.2023.08.020

N/A

0.406DataRank · unranked

14 citations

Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J. Miller +2 more

Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

Cell Reports Medicine(2024)10.1016/j.xcrm.2024.101468

N/A

0.385DataRank · unranked

12 citations

Jie Fang, Hongjian Jin, Shivendra V. Singh, Prahalathan Pichavaram, Qiong Wu +21 more

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Acta Pharmaceutica Sinica B(2023)10.1016/j.apsb.2023.07.014

N/A

0.373DataRank · unranked

11 citations

Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett‐Miller +2 more

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research(2023)10.1093/nar/gkad1175

N/A

0.352DataRank · unranked

7 citations

Shyaron Poudel, Jing Wu, Darcie J. Miller, Wenwei Lin, Lei Yang +7 more

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.25.432934

N/A

0.292DataRank · unranked

6 citations

William C. Wright, Rich Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder +24 more

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators

Structure(2025)10.1016/j.str.2025.09.011

N/A

0.165DataRank · unranked

2 citations

Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu, Darcie J. Miller +2 more

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.06.407973

Top 71%

0.123DataRank

Top 71%1 citations

Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin +34 more

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.12.536612

N/A

0.104DataRank · unranked

1 citations

William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang +16 more

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader

ChemRxiv(2021)10.26434/chemrxiv-2021-zvq4t

N/A

0.104DataRank · unranked

1 citations

Huda Zahid, Wenwei Lin, Taosheng Chen, Daniel A. Harki, William C. K. Pomerantz +1 more

Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells

Cancer & Metabolism(2023)10.1186/s40170-023-00303-5

N/A

0DataRank · unranked

26 citations

Mollie Merrell, Anna G. Skubiz, Noah Thornton, Sandra Milasta, Douglas R. Green +6 more

A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics

Nature Communications(2023)10.1038/s41467-023-43134-0

N/A

0DataRank · unranked

23 citations

William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang +16 more

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217804120

N/A

0DataRank · unranked

18 citations

Andrew D. Huber, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

Genes & Diseases(2023)10.1016/j.gendis.2023.101079

N/A

0DataRank · unranked

6 citations

Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D. Huber +6 more

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00343

N/A

0DataRank · unranked

5 citations

Molly Sneddon, Joseph E. McPherson, Sourav Das, Clifford T. Gee, Michael J. Grillo +7 more

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small Molecule Inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-8t7wn

N/A

0DataRank · unranked

1 citations

Molly Sneddon, Joseph McPherson, Sourav Das, Clifford T. Gee, Michael A. Grillo +7 more

Data from Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation

(2023)10.1158/1078-0432.c.6530622

N/A

0DataRank · unranked

0 citations

Mingqing Chen, Kyle Z. Pasquariello, Alice A. Gibson, James J. Petti, Shichen Shen +11 more

Structure-guided approach to modulate small molecule binding to the promiscuous pregnane X receptor

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.524030

N/A

0DataRank · unranked

0 citations

Wenwei Lin, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

Determination of Regulation of Drug Metabolizing Enzymes and Transporters

(2023)10.1002/9781119660699.ch41

N/A

0DataRank · unranked

0 citations

Taosheng Chen, Wen Xie, Sergio C. Chai

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Nature Communications(2024)10.1038/s41467-024-48472-1

N/A

0DataRank · unranked

20 citations

Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu +5 more

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network

Structure(2024)10.1016/j.str.2024.09.016

N/A

0DataRank · unranked

10 citations

Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chen, Andrew D. Huber

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01926

N/A

0DataRank · unranked

10 citations

Kwan‐Young Jung, Yongtao Li, Wenwei Lin, Jing Wu, Shyaron Poudel +5 more

Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition

iScience(2024)10.1016/j.isci.2024.110289

N/A

0DataRank · unranked

9 citations

Jing Wu, Yang Ka, Junmin Peng, Taosheng Chen, Meritxell B. Cutrona

Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.06.592815

N/A

0DataRank · unranked

1 citations

Richard D. Lutze, Matthew A. Ingersoll, Regina G. Kelmann, K.H. Ly, Duane Currier +4 more

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

Cell(2025)10.1016/j.cell.2025.11.002

N/A

0DataRank · unranked

43 citations

Jianlin Lu, Alexandre F. Carisey, Sangappa B. Chadchan, Ha Won Lee, R. K. Subbarao Malireddi +12 more

Decoding the selective chemical modulation of CYP3A4

Nature Communications(2025)10.1038/s41467-025-58749-8

N/A

0DataRank · unranked

6 citations

Stanley Nithianantham, Sergio C. Chai, Kwan‐Young Jung, Lei Yang, Han Wee Ong +5 more

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

Nature Communications(2025)10.1038/s41467-025-64773-5

N/A

0DataRank · unranked

1 citations

Wenwei Lin, Kwan‐Young Jung, Shyaron Poudel, Guangwei Yang, Jing Wu +15 more

Receptor Allostery Promotes Context-Dependent Sonic Hedgehog Signaling During Embryonic Development

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.28.635336

N/A

0DataRank · unranked

0 citations

Miriam E. Dillard, Mohamed Ghonim, Yan Zhang, Daniel P. Stewart, Robin Canac +11 more

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b02067

N/A

0DataRank · unranked

59 citations

Jude Chenge, Jingheng Wang, Hazel M. Girvan, Lei Yang, Sergio C. Chai +6 more

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.20.689490

N/A

0DataRank · unranked

0 citations

Yang Xu, Mingrui Zhu, Xinran Dong, Honglei Zhou, Brandon Bianski +14 more

KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion

Scientific Reports(2020)10.1038/s41598-020-58448-y

N/A

0DataRank · unranked

11 citations

Jesse Bakke, William C. Wright, Taosheng Chen, Peter Oladimeji

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid

Cells(2020)10.3390/cells9071654

N/A

0DataRank · unranked

9 citations

Kiran Kodali, Jing Wu, Timothy I. Shaw, Junmin Peng, Taosheng Chen +1 more

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

Cell Death Discovery(2020)10.1038/s41420-020-00342-7

N/A

0DataRank · unranked

9 citations

Joseph N. Miller, Raju R. Rayavarapu, Zhenya Hong, Gamze B. Bulut, Wei Zhuang +8 more

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Cancer Research(2020)10.1158/0008-5472.can-19-3934

N/A

0DataRank · unranked

41 citations

Liying Chi, Mi‐Kyung Yun, Lyudmila Tsurkan, Nancy E. Martinez, Barbara Jonchère +25 more

PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches

Expert Opinion on Drug Metabolism & Toxicology(2020)10.1080/17425255.2020.1779701

N/A

0DataRank · unranked

32 citations

Monicah N Bwayi, Rebecca R. Florke Gee, Taosheng Chen, Jingheng Wang

MEKK3-MEK5-ERK5 Signaling Promotes Mitochondrial Degradation

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.15.098442

N/A

0DataRank · unranked

0 citations

Joseph N. Miller, Raju R. Rayavarapu, Zhenya Hong, Gamze B. Bulut, Wei Zhuang +8 more

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Angewandte Chemie International Edition(2021)10.1002/anie.202108848

N/A

0DataRank · unranked

159 citations

Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchère, Seung Wook Yang, Jamie Jarusiewicz +22 more

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

Nature Communications(2021)10.1038/s41467-021-26640-x

N/A

0DataRank · unranked

93 citations

William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder +25 more

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Angewandte Chemie(2021)10.1002/ange.202108848

N/A

0DataRank · unranked

15 citations

Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchère, Seung Wook Yang, Jamie Jarusiewicz +22 more

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Nucleic Acids Research(2022)10.1093/nar/gkac133

N/A

0DataRank · unranked

38 citations

Efren Garcia-Maldonado, Sergio C. Chai, Boer Xie, Shirish Chodankar, Andrew D. Huber +10 more

Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library

Biochemistry(2022)10.1021/acs.biochem.2c00256

N/A

0DataRank · unranked

6 citations

Ka Yang, Xue Zhang, Yingxue Fu, Jay M. Yarbro, Zhiping Wu +4 more

Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis

Science Advances(2023)10.1126/sciadv.adg8156

N/A

0DataRank · unranked

59 citations

Luigi Mari, Nicholas J. Barrows, Mao Yang, Sebastian Ruehl, Jinan Chen +5 more

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

Blood(2023)10.1182/blood.2023021359

N/A

0DataRank · unranked

58 citations

Milad Rasouli, Masayuki Umeda, Ryan Hiltenbrand, Sherif Abdelhamed, Rebecca Mohnani +23 more

Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

Nature Communications(2023)10.1038/s41467-023-39717-6

N/A

0DataRank · unranked

43 citations

Shivendra V. Singh, Changde Cheng, Sivaraman Natarajan, Heather Sheppard, Ahmed Abu‐Zaid +24 more

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity

Molecular Cell(2023)10.1016/j.molcel.2023.01.019

N/A

0DataRank · unranked

38 citations

Moeko T. King, Kheewoong Baek, Clifford T. Gee, Ravi Kalathur, Jerry Li +10 more

Taosheng Chen

Indexed papers

Top data-sharing exemplar

Papers