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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure(2023)10.1016/j.str.2023.08.020Source: DataRank Database

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand is a research paper published in Structure (2023). On theSindex it has a DataRank of 0. It has been cited 14 times.

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Open Access14 citations

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Enrichment:Funding (10 grants)Impact (FWCI 3.57)OA: bronzeTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Shyaron Poudel ORCID,Yongtao Li ORCID,Wenwei Lin ORCID,Jing Wu ORCID,Darcie J. Miller

Live enrichment

PubMed:37729916 PMC:PMC10872772 OpenAlex:https://openalex.org/W4386865188

National Institute of General Medical Sciences

Grant: R35GM118041

National Institute of General Medical Sciences

Grant: S10_OD027000

National Institute of General Medical Sciences

Grant: S10_RR028976

National Institute of General Medical Sciences

Grant: S10_RR25528

Basic Energy Sciences

Grant: W-31-109-Eng-38

Argonne National Laboratory

National Institutes of Health

Office of Science

U.S. Department of Energy

American Lebanese Syrian Associated Charities

FWCI

3.57

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://www.cell.com/article/S0969212623002976/pdf

publisherhttp://www.cell.com/article/S0969212623002976/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0969212623002976?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212623002976?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2023.08.020

Fields of Study

Cholesterol and Lipid MetabolismHormonal Regulation and HypertensionPharmacogenetics and Drug MetabolismHumansPregnane X ReceptorReceptors, SteroidLigandsReceptors, Cytoplasmic and NuclearFluorocarbonsBenzenesulfonamides

MeSH Terms

Pregnane X ReceptorBenzenesulfonamidesFluorocarbonsHumansLigandsReceptors, SteroidReceptors, Cytoplasmic and Nuclear

Keywords

Pregnane X receptorNuclear receptorLigand (biochemistry)ChemistryLiver X receptorReceptorBinding siteSelectivityTranscription factorAgonistStereochemistryBiochemistryBiophysicsBiologyGeneDrug designPromiscuity

Sustainable Development Goals

SDG 0: Good health and well-being

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

FAIR Checklist

Authors (7)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)