Timothy M. Frayling

Also affiliated with University of Exeter

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

9.6Author DataRank

Indexed papers

6in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 6 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A structural variation reference for medical and population genetics

Nature(2020)10.1038/s41586-020-2287-8

Top 3%

6.7DataRank

Top 3%1180 citations

Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli +201 more

Papers

Driven by 48 papers — median percentile 92. Top paper: “A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity”.

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Science(2007)10.1126/science.1141634

N/A

18.0DataRank · unranked

4497 citations

Nicholas J. Timpson, Michael N. Weedon, Eleftheria Zeggini, Rachel M. Freathy, Cecilia M. Lindgren +36 more

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics(2021)10.1038/s41588-021-00913-z

N/A

11.2DataRank · unranked

2226 citations

Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng +89 more

A structural variation reference for medical and population genetics

Nature(2020)10.1038/s41586-020-2287-8

Top 3%

6.7DataRank

Top 3%1180 citations

Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli +201 more

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications(2020)10.1038/s41467-019-12438-5

N/A

5.6DataRank · unranked

143 citations

James Zou, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier +174 more

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nature Communications(2020)10.1038/s41467-019-10717-9

N/A

5.2DataRank · unranked

191 citations

Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans +181 more

The effect of LRRK2 loss-of-function variants in humans

Nature Medicine(2020)10.1038/s41591-020-0893-5

N/A

4.9DataRank · unranked

114 citations

Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric V. Minikel, Julia K. Goodrich +214 more

Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations

American Journal of Epidemiology(2009)10.1093/aje/kwp145

N/A

4.0DataRank · unranked

67 citations

Lorraine Southam, David Altshuler, Kristin G. Ardlie, Inês Barroso, Michael Boehnke +27 more

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Nature Communications(2018)10.1038/s41467-018-04668-w

N/A

3.7DataRank · unranked

109 citations

Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan M. Bloom, Timothy Poterba +442 more

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Nature Communications(2018)10.1038/s41467-018-03911-8

N/A

3.1DataRank · unranked

104 citations

Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam +43 more

Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation

PLoS ONE(2013)10.1371/journal.pone.0064343

N/A

2.9DataRank · unranked

75 citations

John R. B. Perry, Toshiko Tanaka, Dena G. Hernandez, Hou-Feng Zheng, David Melzer +10 more

The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits

Cell Metabolism(2023)10.1016/j.cmet.2023.03.001

Top 8%

2.7DataRank

Top 8%136 citations

Marcin von Grotthuss, Jeffrey Massung, Dongkeun Jang, Lizz Caulkins, Ryan Koesterer +82 more

Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis

JNCI Journal of the National Cancer Institute(2022)10.1093/jnci/djac011

N/A

2.2DataRank · unranked

103 citations

Mingyang Song, Nikos Papadimitriou, Robert Carreras‐Torres, Claudia Langenberg, Richard M Martin +20 more

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Nature Genetics(2023)10.1038/s41588-023-01408-9

N/A

1.5DataRank · unranked

78 citations

Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley, Swarooparani Vadlamudi +94 more

Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study

Diabetes Care(2022)10.2337/dc21-0089

N/A

1.4DataRank · unranked

60 citations

Rebecca Richmond, Jack Bowden, Ciarrah-Jane Barry, Hassan S. Dashti, Iyas Daghlas +14 more

The mutational constraint spectrum quantified from variation in 141,456 humans

Nature(2020)10.1038/s41586-020-2308-7

N/A

1.4DataRank · unranked

9958 citations

Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo S. Wang +187 more

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

eLife(2021)10.7554/elife.72452

N/A

1.3DataRank · unranked

44 citations

Jessica Tyrrell, E. Louise Thomas, Matthew J. Bown, Andrew R. Wood, Robin N. Beaumont +19 more

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

Proceedings of the National Academy of Sciences(2017)10.1073/pnas.1705859115

N/A

1.2DataRank · unranked

36 citations

Alisa Manning, Marcio Almeida, Matthew Zawistowski, Katharina Domschke, Tanya M. Teslovich +82 more

Defining the role of common variation in the genomic and biological architecture of adult human height

Nature Genetics(2014)10.1038/ng.3097

N/A

1.1DataRank · unranked

2093 citations

Emilio Rodríguez-Ruiz, The PAGE Consortium, Diana O. Perkins, Tonu Esko, Jian Yang +479 more

Efficient Bayesian mixed-model analysis increases association power in large cohorts

Nature Genetics(2015)10.1038/ng.3190

N/A

1.1DataRank · unranked

1781 citations

George Tucker, Brendan K Bulik-Sullivan, Bjarni J. Vilhjálmsson, Hilary K. Finucane, Rany M. Salem +9 more

OTTERS: a powerful TWAS framework leveraging summary-level reference data

Nature Communications(2023)10.1038/s41467-023-36862-w

N/A

1.1DataRank · unranked

56 citations

Geyu Zhou, Luca Pinello, Urmo Võsa, Lude Franke, Alexis Battle +81 more

The genetic architecture of type 2 diabetes

Nature(2016)10.1038/nature18642

N/A

1.1DataRank · unranked

1106 citations

Menachem Fromer, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton +334 more

Understanding multicellular function and disease with human tissue-specific networks

Nature Genetics(2015)10.1038/ng.3259

N/A

1.0DataRank · unranked

925 citations

Krishnan, Arjun, Aaron K. Wong, Emanuela Ricciotti, Daniel S. Himmelstein, Ran Zhang +12 more

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.01.002

N/A

0.984DataRank · unranked

46 citations

Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P Wilson, Anne H. Moxley +66 more

Transcript expression-aware annotation improves rare variant interpretation

Nature(2020)10.1038/s41586-020-2329-2

N/A

0.796DataRank · unranked

201 citations

Konrad J. Karczewski, Ditte Demontis, Eleanor G. Seaby, Nicholas A. Watts, Moriel Singer-Berk +177 more

Evaluating drug targets through human loss-of-function genetic variation

Nature(2020)10.1038/s41586-020-2267-z

N/A

0.779DataRank · unranked

179 citations

Konrad J. Karczewski, Hilary C. Martin, Beryl B. Cummings, Nicola Whiffin, Daniel R. Rhodes +150 more

Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels

Nature Genetics(2025)10.1038/s41588-025-02095-4

N/A

0.449DataRank · unranked

19 citations

V. Kartik Chundru, Leigh Jackson, Kashyap A. Patel, Anna Murray, Andrew R. Wood +5 more

Blood‐based multivariate methylation risk score for cognitive impairment and dementia

Alzheimer s & Dementia(2024)10.1002/alz.14061

N/A

0.434DataRank · unranked

17 citations

Rachel Cavill, Rick A. Reijnders, Joshua Harvey, Jan Homann, Morteza Kouhsar +52 more

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.08.004

N/A

0.396DataRank · unranked

13 citations

Josan Gandawijaya, Rosemary A. Bamford, Emily-Rose Martin, Andrew R. Wood, Peter J. van der Most +28 more

Identification and analysis of individuals who deviate from their genetically-predicted phenotype

PLoS Genetics(2023)10.1371/journal.pgen.1010934

N/A

0.385DataRank · unranked

12 citations

Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N. Beaumont, Jessica Tyrrell +5 more

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Nature Communications(2020)10.1038/s41467-020-15236-6

Top 57%

0.275DataRank

Top 57%2 citations

Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan M. Bloom, Timothy Poterba +442 more

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Oxford University Research Archive (ORA) (University of Oxford)(2020)10.17615/gc55-0r45

N/A

0.221DataRank · unranked

2 citations

Sonsoles Morcillo, Nicholas J. Wareham, Richard A. Jensen, Allan Linnenberg, Josée Dupuis +74 more

Chapter 1 Transcription factor genes in type 2 diabetes

Advances in Molecular and Cellular Endocrinology(2006)10.1016/s1569-2566(06)05001-0

N/A

0.208DataRank · unranked

3 citations

Andrew T. Hattersley, Timothy M. Frayling, Michael N. Weedon

The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study

medRxiv(2022)10.1101/2022.10.11.22280427

N/A

0DataRank · unranked

1 citations

Rebecca Richmond, Emma L. Anderson, Jack Bowden, Ciarrah-Jane Barry, Hassan S. Dashti +18 more

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Nature Methods(2025)10.1038/s41592-025-02919-5

N/A

0DataRank · unranked

0 citations

Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj, Zilin Li, Hufeng Zhou +544 more

Across-cohort QC analyses of GWAS summary statistics from complex traits

UNC Libraries(2020)10.17615/mfev-3g68

N/A

0DataRank · unranked

0 citations

Jian Yang, Matthew R. Robinson, Sang Lee, Peter M. Visscher, Guo‐Bo Chen +12 more

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Diabetologia(2023)10.1007/s00125-023-05923-6

N/A

0DataRank · unranked

18 citations

Robin N. Beaumont, Jessica Tyrrell, Grace M. Power, Andrew R. Wood, Markku Laakso +7 more

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion

medRxiv(2023)10.1101/2023.02.03.23285420

N/A

0DataRank · unranked

1 citations

Robin N. Beaumont, Jessica Tyrrell, Grace M. Power, Andrew R. Wood, Markku Laakso +7 more

The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study

Scientific Reports(2024)10.1038/s41598-024-58007-9

N/A

0DataRank · unranked

4 citations

Rebecca Richmond, Emma L. Anderson, Jack Bowden, Ciarrah-Jane Barry, Hassan S. Dashti +18 more

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.24.639925

N/A

0DataRank · unranked

3 citations

Harrison I. W. Wright, Robin N. Beaumont, V. Kartik Chundru, Aimee Hanson, Leigh Jackson +7 more

Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.06.686913

N/A

0DataRank · unranked

0 citations

Harrison I.W. Wright, Timothy M. Frayling, Andrew R. Wood, Michael N. Weedon, Caroline F. Wright +3 more

Federated cross-biobank conditional analysis identifies LDL-C lowering effects of DNAJC13 haploinsufficiency and LDLR regulation

bioRxiv (Cold Spring Harbor Laboratory)(2026)10.64898/2026.02.03.702791

N/A

0DataRank · unranked

0 citations

Liza Darrous, Lauric Ferrat, V. Kartik Chundru, Aurelie Kamoun, Katharina Domschke +9 more

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

UNC Libraries(2020)10.17615/2bje-6g29

N/A

0DataRank · unranked

0 citations

Deborah J. Thompson, Hannes Helgason, Timothy M. Frayling, Hilary K. Finucane, Patrick Sulem +211 more

Genome-wide meta-analysis of common variant differences between men and women

Faculty of Health; Institute of Health and Biomedical Innovation(2020)10.17615/psgr-b356

N/A

0DataRank · unranked

0 citations

Vincenza Colonna, Timothy M. Frayling, Stefania Bandinelli, Tōnu Esko, Jeanette Erdmann +27 more

Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight

Human Molecular Genetics(2021)10.1093/hmg/ddab356

N/A

0DataRank · unranked

8 citations

Robin N. Beaumont, Alan Kuang, Nicole M. Warrington, Yingjie Ji, Jessica Tyrrell +15 more

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

medRxiv(2021)10.1101/2021.12.10.21267599

N/A

0DataRank · unranked

4 citations

Eleanor Sanderson, Vanessa Y Tan, Katherine S. Ruth, Timothy M. Frayling, Niki Dimou +10 more

Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease.

Research Square(2021)10.21203/rs.3.rs-537397/v2

N/A

0DataRank · unranked

0 citations

Jessica Tyrrell, E. Louise Thomas, Matthew J. Bown, Andrew R. Wood, Robin N. Beaumont +18 more

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

UNC Libraries(2020)10.17615/55vz-3f21

N/A

0DataRank · unranked

0 citations

Richard N. Bergman, Katherine S. Elliott, Harald Grallert, Eleftheria Zeggini, Peter Almgren +27 more

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

medRxiv(2020)10.1101/2020.11.13.20224360

N/A

0DataRank · unranked

0 citations

A G Jones, Jonathan P Evans, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell +4 more

Timothy M. Frayling

Indexed papers

Top data-sharing exemplar

Papers