Mark J. Henderson

Also affiliated with National Center for Advancing Translational Sciences

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 33 papers. Top paper: “Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors”.

Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00193

N/A

3.1DataRank · unranked

90 citations

Gregory J. Tawa, Mark J. Henderson, Carina Danchik, Suiyang Liu, Pranav Shah +10 more

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00916

N/A

1.7DataRank · unranked

63 citations

Daniel J. Urban, Bryan T. Mott, Xin Hu, Shyh‐Ming Yang, Gloria A. Benavides +40 more

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Cell Reports(2021)10.1016/j.celrep.2021.109040

N/A

0.515DataRank · unranked

30 citations

Kathleen A. Trychta, Shyh‐Ming Yang, Susanne Bäck, Adam Yasgar, Emily S. Wires +21 more

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Nature Communications(2023)10.1038/s41467-023-40537-x

N/A

0.489DataRank · unranked

25 citations

Yongwang Zhong, Xin Hu, Tuan Xu, Ying‐Hua Zhang, Stephen C. Kales +13 more

High-Throughput Cellular Thermal Shift Assay Using Acoustic Transfer of Protein Lysates

ACS Chemical Biology(2022)10.1021/acschembio.1c00760

N/A

0.442DataRank · unranked

18 citations

Michael J. Iannotti, Tino W. Sanchez, Ty C. Voss, Abhijeet Kapoor, Matthew D. Hall +5 more

High-Throughput Detection of Ligand-Protein Binding Using a SplitLuc Cellular Thermal Shift Assay

Methods in molecular biology(2021)10.1007/978-1-0716-1665-9_2

N/A

0.416DataRank · unranked

15 citations

Ashley E. Owens, Natalia J. Martinez, Eric Wallgren, Anton Simeonov, Mark J. Henderson +1 more

XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6

Human Molecular Genetics(2022)10.1093/hmg/ddac010

N/A

0.330DataRank · unranked

8 citations

Wenjing Yan, Jingjing Ruan, Mike Fang, Changjun Yu, Shaojun Du +5 more

The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases

Cancer Research(2025)10.1158/0008-5472.can-24-1793

N/A

0.269DataRank · unranked

5 citations

Yi‐Han Lin, Jeremy Spence, Aleksandra Głogowska, Thatchawan Thanasupawat, Jason Beiko +11 more

Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein–Protein Interactions with a Native VapB1 Inhibitor

Journal of Chemical Information and Modeling(2022)10.1021/acs.jcim.1c01188

N/A

0.269DataRank · unranked

5 citations

Nathan P. Coussens, Carina Danchik, Leah M. Wachsmuth, Mark J. Henderson, Samarjit Patnaik +5 more

Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections

Applied and Environmental Microbiology(2024)10.1128/aem.02046-24

N/A

0.175DataRank · unranked

2 citations

Maxim Chudaev, Wenjuan Ye, Amy Q. Wang, Kenneth J. Wilson, Xin Xu +12 more

Developing a Robust and High Throughput Assay for Screening Innate Immune Training Molecules

The Journal of Immunology(2023)10.4049/jimmunol.210.supp.161.14

N/A

0.104DataRank · unranked

1 citations

Heera James, Mark J. Henderson, Sinu P. John, Iain D. C. Fraser, Greta E Forbes

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Redox Biology(2023)10.1016/j.redox.2023.102611

N/A

0DataRank · unranked

24 citations

Ganesha Rai, A. V. Kozyr, Nathaniel De Jonge, Emily F. Gliniewicz, Lars J. Berg +16 more

High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson’s disease

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2406009121

N/A

0DataRank · unranked

23 citations

Logan M. Glasstetter, Tiffany T. Jong, Tiffany Chen, Abhijeet Kapoor, Sha Zhu +12 more

Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice

Cell Reports(2024)10.1016/j.celrep.2024.114144

N/A

0DataRank · unranked

8 citations

Daniela Gutiérrez, Andrés E. Dulcey, Marcelo Lara, Lina Moitoso de Vargas, Yi‐Han Lin +21 more

Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-23-0790

N/A

0DataRank · unranked

2 citations

Raul Calvo, Anju Kumari, Rushikesh Sable, Yuhong Fang, Dingyin Tao +17 more

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.22.586364

N/A

0DataRank · unranked

3 citations

Logan M. Glasstetter, Tiffany T. Jong, Abhijeet Kapoor, Sha Zhu, Yanping Zhu +8 more

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1 ‐Associated Parkinsonism

Movement Disorders(2025)10.1002/mds.70168

N/A

0DataRank · unranked

1 citations

Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan Marugán, Ellen Sidransky +1 more

Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

Biochemical Pharmacology(2025)10.1016/j.bcp.2025.117300

N/A

0DataRank · unranked

1 citations

Abigail M Keith, Wenjuan Ye, Xin Hu, Noel Southall, Juan Marugán +6 more

Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.16.649181

N/A

0DataRank · unranked

0 citations

Abigail M Keith, Wenjuan Ye, Xin Hu, Noel Southall, Juan J. Marugan +6 more

An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine

Analytical Chemistry(2025)10.1021/acs.analchem.4c06628

N/A

0DataRank · unranked

0 citations

Yuhong Fang, Maya L. Gosztyla, Edward L. Zhu, Abhijeet Kapoor, Andrés E. Dulcey +12 more

Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.23.661126

N/A

0DataRank · unranked

0 citations

Charis Ma, Richard Sam, Jens Lichtenberg, Tiffany Chen, Ying Hao +16 more

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

ACS Infectious Diseases(2020)10.1021/acsinfecdis.0c00349

N/A

0DataRank · unranked

93 citations

Catherine Z. Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu-Shan Cheng +21 more

SCOPE: Revealing Hidden Mechanisms in Phenotypic Screens Through Target and Pathway Enrichment

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.11.664427

N/A

0DataRank · unranked

0 citations

Keith J. Kelleher, Suzanne M. Underhill, Sankalp Jain, Brandon K. Harvey, Mark J. Henderson +1 more

The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101191

N/A

0DataRank · unranked

40 citations

Warunee Dansithong, Stephen C. Kales, Sharan Paul, Gentrie Maag, Erika Aoyama +12 more

Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00019

N/A

0DataRank · unranked

29 citations

Karavadhi Surendra, Rajan Pragani, Li Liu, Yuhong Fang, Weihe Zhang +28 more

A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity

Scientific Reports(2021)10.1038/s41598-021-85279-2

N/A

0DataRank · unranked

9 citations

Hongxuan Feng, Xin Hu, Xin Sun, Wang Zheng, Pan P. Li +10 more

Inhibiting SARS‐CoV‐2 infection with lysosomal alkalizers

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.02122

N/A

0DataRank · unranked

0 citations

Catherine Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu‐Shan Cheng +21 more

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.07.467657

N/A

0DataRank · unranked

0 citations

Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris Brown, Punn Augsornworawat +12 more

Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome

JCI Insight(2022)10.1172/jci.insight.156549

N/A

0DataRank · unranked

30 citations

Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris Brown, Punn Augsornworawat +12 more

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102228

N/A

0DataRank · unranked

21 citations

Mandi Gandelman, Sharan Paul, Thomas S. Dexheimer, Warunee Dansithong, Karla P. Figueroa +11 more

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Frontiers in Pharmacology(2022)10.3389/fphar.2022.899536

N/A

0DataRank · unranked

11 citations

Elias Carvalho Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez +6 more

Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2

Communications Biology(2022)10.1038/s42003-022-04143-9

N/A

0DataRank · unranked

9 citations

Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel Southall +13 more

RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r2398

N/A

0DataRank · unranked

0 citations

Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel Southall +10 more