Ruili Huang

Also affiliated with National Center for Advancing Translational Sciences

Computer SciencePharmacology, Toxicology and PharmaceuticsVeterinaryBiochemistry, Genetics and Molecular BiologyEnvironmental Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

6.7Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00264

Top 4%

5.0DataRank

Top 4%314 citations

Ruili Huang, Suramya Waidyanatha, Paul Shinn, Bradley J. Collins, Inthirany Thillainadarajah +19 more

Papers

Driven by 68 papers — median percentile 91. Top paper: “The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology”.

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00264

Top 4%

5.0DataRank

Top 4%314 citations

Ruili Huang, Suramya Waidyanatha, Paul Shinn, Bradley J. Collins, Inthirany Thillainadarajah +19 more

High-Throughput Screening to Predict Chemical-Assay Interference

Scientific Reports(2020)10.1038/s41598-020-60747-3

Top 13%

1.6DataRank

Top 13%43 citations

Ruili Huang, Srilatha Sakamuru, Menghang Xia, Anton Simeonov, Kamel Mansouri +4 more

Predictive Models for Human Organ Toxicity Based on In Vitro Bioactivity Data and Chemical Structure

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.9b00305

N/A

1.1DataRank · unranked

39 citations

Deborah K. Ngan, Lin Ye, Menghang Xia, Heidi Q. Xie, Bin Zhao +3 more

Systematic Identification of Molecular Targets and Pathways Related to Human Organ Level Toxicity

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00305

N/A

0.966DataRank · unranked

25 citations

Weida Tong, Menghang Xia, Anton Simeonov, Ruili Huang, Tuan Xu

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2

Nature Biotechnology(2021)10.1038/s41587-021-00839-1

N/A

0.601DataRank · unranked

54 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu, Emily M. Lee +15 more

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

Frontiers in Bioengineering and Biotechnology(2020)10.3389/fbioe.2020.00109

N/A

0.584DataRank · unranked

48 citations

Xue Liu, Masato Ooka, Li Zhang, Min Jae Song, Ruili Huang +5 more

Deep Graph Learning with Property Augmentation for Predicting Drug-Induced Liver Injury

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00322

N/A

0.550DataRank · unranked

38 citations

Weizhi An, Yuhong Wang, Hongmao Sun, Ruili Huang, Junzhou Huang +1 more

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Scientific Reports(2021)10.1038/s41598-021-86110-8

N/A

0.520DataRank · unranked

31 citations

Catherine Z. Chen, Srilatha Sakamuru, Jinghua Zhao, Deborah K. Ngan, Anton Simeonov +5 more

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Nature Communications(2023)10.1038/s41467-023-40537-x

N/A

0.489DataRank · unranked

25 citations

Yongwang Zhong, Xin Hu, Tuan Xu, Ying‐Hua Zhang, Stephen C. Kales +13 more

Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00230

N/A

0.464DataRank · unranked

21 citations

Shuaizhang Li, Andrew J. Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang +3 more

Use of Tox21 screening data to profile PFAS bioactivities on nuclear receptors, cellular stress pathways, and cytochrome p450 enzymes

Journal of Hazardous Materials(2024)10.1016/j.jhazmat.2024.134642

N/A

0.449DataRank · unranked

19 citations

Srilatha Sakamuru, Jinghua Zhao, Yanyan Qu, Yuhong Fang, Dingyin Tao +6 more

Evaluation of chemical compounds that inhibit neurite outgrowth using GFP-labeled iPSC-derived human neurons

NeuroToxicology(2021)10.1016/j.neuro.2021.01.003

N/A

0.434DataRank · unranked

17 citations

Li Zhang, Ruili Huang, Tuan Xu, Fred Parham, Mamta Behl +2 more

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

PLoS ONE(2022)10.1371/journal.pone.0261854

N/A

0.425DataRank · unranked

16 citations

Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck, J. Christopher Corton +1 more

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

Genomics Proteomics & Bioinformatics(2021)10.1016/j.gpb.2020.06.016

N/A

0.396DataRank · unranked

13 citations

Emily M. Lee, Jianbo Pan, Miao Xu, Hee‐Sool Rho, Yichen Cheng +20 more

Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action

Environmental Science & Technology(2025)10.1021/acs.est.4c07995

N/A

0.385DataRank · unranked

12 citations

Jinghua Zhao, Li Zhang, Ruili Huang, Srilatha Sakamuru, Charlotte TeKrony +6 more

Prediction of chemical-induced acute toxicity using in vitro assay data and chemical structure

Toxicology and Applied Pharmacology(2024)10.1016/j.taap.2024.117098

N/A

0.373DataRank · unranked

11 citations

Tuan Xu, Deborah K. Ngan, Menghang Xia, Jinghua Zhao, Srilatha Sakamuru +3 more

NAD activates olfactory receptor 1386 to regulate type I interferon responses in Plasmodium yoelii YM infection

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2403796121

N/A

0.362DataRank · unranked

6 citations

Jian Wu, Xiao He, Jin Dai, Lu Xia, Paola Carolina Valenzuela Leon +11 more

In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity

Toxicology and Applied Pharmacology(2023)10.1016/j.taap.2023.116600

N/A

0.345DataRank · unranked

9 citations

Menghang Xia, Anton Simeonov, Ruili Huang, Deborah K. Ngan

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

Cell Genomics(2024)10.1016/j.xgen.2024.100679

N/A

0.292DataRank · unranked

6 citations

Cleide Dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini, Ruili Huang +92 more

Leveraging viral genome sequences and machine learning models for identification of potentially selective antiviral agents

Communications Chemistry(2025)10.1038/s42004-025-01583-2

N/A

0.241DataRank · unranked

4 citations

Miao Xu, Qi Zhang, Catherine Z. Chen, Wei Zheng, Ruili Huang +1 more

Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation

Toxicology and Applied Pharmacology(2025)10.1016/j.taap.2025.117315

N/A

0.165DataRank · unranked

2 citations

Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Stephen Ferguson, David M. Reif +3 more

Prediction of Drug Targets based on In Vitro Activity Profiles Toward Drug Repurposing for Rare Diseases

PubMed(2023)10.1109/bibm58861.2023.10386046

N/A

0.165DataRank · unranked

2 citations

Ruili Huang, Qian Zhu, Yanji Xu, Binghan Xue

Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity

Toxicology and Applied Pharmacology(2025)10.1016/j.taap.2025.117567

N/A

0.104DataRank · unranked

1 citations

Li Zhang, Srilatha Sakamuru, Precious Adedayo Adesina, Jinghua Zhao, Menghang Xia +13 more

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Frontiers in Pharmacology(2022)10.3389/fphar.2022.899536

N/A

0DataRank · unranked

11 citations

Elias Carvalho Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez +6 more

Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways

Frontiers in Pharmacology(2022)10.3389/fphar.2022.935399

N/A

0DataRank · unranked

11 citations

Ruili Huang, Menghang Xia, Srilatha Sakamuru

Lestaurtinib induces DNA damage that is related to estrogen receptor activation

Current Research in Toxicology(2022)10.1016/j.crtox.2022.100102

N/A

0DataRank · unranked

4 citations

Shu Yang, Li Zhang, Kota Kojima, Ruili Huang, Kouji Hirota +3 more

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.26.505462

N/A

0DataRank · unranked

1 citations

Erin Oliphant, Bryan Queme, Laurence Lamy, Yuhong Wang, Ruili Huang +4 more

High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions

The Annual Review of Pharmacology and Toxicology(2023)10.1146/annurev-pharmtox-112122-104310

N/A

0DataRank · unranked

55 citations

Srilatha Sakamuru, Masato Ooka, Ruili Huang, Carleen Klumpp‐Thomas, Paul Shinn +10 more

High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice

Acta Pharmaceutica Sinica B(2023)10.1016/j.apsb.2023.10.017

N/A

0DataRank · unranked

27 citations

Mengwei Niu, Shaogui Wang, Xiaowen Ma, Xiao Yang, Hua Sun +10 more

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

Disease Models & Mechanisms(2023)10.1242/dmm.049863

N/A

0DataRank · unranked

18 citations

Erin Oliphant, Bryan Queme, Laurence Lamy, Yuhong Wang, Ruili Huang +4 more

In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review

Food and Chemical Toxicology(2023)10.1016/j.fct.2023.113948

N/A

0DataRank · unranked

18 citations

Ruili Huang, Minjun Chen, Hyun Kil Shin

Three-Dimensional Structural Insights Have Revealed the Distinct Binding Interactions of Agonists, Partial Agonists, and Antagonists with the µ Opioid Receptor

International Journal of Molecular Sciences(2023)10.3390/ijms24087042

N/A

0DataRank · unranked

13 citations

Jie Liu, Fan Dong, Nancy Chang, Ruili Huang, Menghang Xia +3 more

Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.2c01516

N/A

0DataRank · unranked

13 citations

Md Kabir, Srilatha Sakamuru, Pranav Shah, Elias Carvalho Padilha, Deborah K. Ngan +5 more

Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library

Computational Toxicology(2023)10.1016/j.comtox.2023.100271

N/A

0DataRank · unranked

1 citations

Katie Paul Friedman, Keith A. Houck, Li Zhang, Ruili Huang, Menghang Xia +3 more

Fingerprinting Interactions between Proteins and Ligands for Facilitating Machine Learning in Drug Discovery

Biomolecules(2024)10.3390/biom14010072

N/A

0DataRank · unranked

33 citations

Ruili Huang, Menghang Xia, Tucker A. Patterson, Huixiao Hong, Zoe Li

Exploring NCATS in-house biomedical data for evidence-based drug repurposing

PLoS ONE(2024)10.1371/journal.pone.0289518

N/A

0DataRank · unranked

4 citations

Andrew Patt, Chloe Chen, Ruili Huang, Yanji Xu, Ewy A. Mathé +2 more

3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.01.004

N/A

0DataRank · unranked

6 citations

Ruili Huang, John Braisted, Pei‐Hsuan Chu, Anton Simeonov, David Gerhold +1 more

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Frontiers in Toxicology(2024)10.3389/ftox.2024.1321857

N/A

0DataRank · unranked

6 citations

Tuan Xu, Judy Strickland, Li Zhang, Yuhong Fang, Dingyin Tao +5 more

Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development

Molecules(2024)10.3390/molecules29112635

N/A

0DataRank · unranked

3 citations

Ruili Huang, Menghang Xia, Nancy Chang, Wenjing Guo, Jie Liu +7 more

ICRF193 potentiates the genotoxicity of etoposide

Scientific Reports(2025)10.1038/s41598-025-03522-6

N/A

0DataRank · unranked

1 citations

Leah Mitchell, Jinghua Zhao, Kouji Hirota, Ruili Huang, Takuya Abe +2 more

Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system

Toxicological Sciences(2025)10.1093/toxsci/kfaf020

N/A

0DataRank · unranked

2 citations

Kristin M. Eccles, Cynthia V. Rider, Srilatha Sakamuru, Menghang Xia, Ruili Huang +4 more

Expanded Tox21 Biological Assay Panel for the Prediction of Drug-Induced Liver Injury and Cardiotoxicity

Environmental Health Perspectives(2025)10.1021/ehp.6c00052

N/A

0DataRank · unranked

1 citations

Masato Ooka, Jinghua Zhao, Srilatha Sakamuru, Deborah K. Ngan, Li Zhang +13 more

Systematic identification of cancer pathways and potential drugs for intervention through multi-omics analysis

The Pharmacogenomics Journal(2025)10.1038/s41397-025-00361-6

N/A

0DataRank · unranked

2 citations

Deborah K. Ngan, Wei Zheng, Ruili Huang, Tuan Xu

MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100244

N/A

0DataRank · unranked

2 citations

Srilatha Sakamuru, James Travers, Tuan Xu, Shu Yang, Menghang Xia +4 more

Genetic Variants of GBP4: Reduced Risks for Drug‐Induced Acute Liver Failure in Non‐Finnish European Population

Liver International(2025)10.1111/liv.70011

N/A

0DataRank · unranked

1 citations

Menghang Xia, Paul H. Hayashi, Bohun Pan, Guruprasad P. Aithal, M. Isabel Lucena +7 more

Identifying androgen receptor antagonists using a metabolically competent high-throughput screening assay

Current Research in Toxicology(2025)10.1016/j.crtox.2025.100278

N/A

0DataRank · unranked

0 citations

Pranav Shah, Jinghua Zhao, Xin Xu, Ruili Huang, Menghang Xia +1 more

The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2004332117

N/A

0DataRank · unranked

46 citations

Lu Xia, Xiangyu Yao, Xiao Yu, Keyla C. Tumas, Wenxiang Sun +15 more

Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.114368

N/A

0DataRank · unranked

25 citations

Srilatha Sakamuru, Ruili Huang, Jake Niebler, Stephen Ferguson, Menghang Xia +1 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.18.255877

N/A

0DataRank · unranked

30 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.27.223578

N/A

0DataRank · unranked

15 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Emily M. Lee, Shihua He +11 more

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

UNC Libraries(2020)10.17615/dsv6-m426

N/A

0DataRank · unranked

0 citations

Raymond R. Tice, Oksana Kosyk, Yi‐Hui Zhou, Fred A. Wright, Menghang Xia +8 more

AI-based language models powering drug discovery and development

Drug Discovery Today(2021)10.1016/j.drudis.2021.06.009

N/A

0DataRank · unranked

158 citations

Ruth Roberts, Madhu Lal‐Nag, Xi Chen, Ruili Huang, Weida Tong +1 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Frontiers in Pharmacology(2021)10.3389/fphar.2020.592737

N/A

0DataRank · unranked

95 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Trade-off Predictivity and Explainability for Machine-Learning Powered Predictive Toxicology: An in-Depth Investigation with Tox21 Data Sets

Chemical Research in Toxicology(2021)10.1021/acs.chemrestox.0c00373

N/A

0DataRank · unranked

67 citations

Ruili Huang, Igor V. Tetko, Zhonghua Xia, Joshua Xu, Weida Tong

Identification of Compounds for Butyrylcholinesterase Inhibition

SLAS DISCOVERY(2021)10.1177/24725552211030897

N/A

0DataRank · unranked

56 citations

Andrew J. Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp‐Thomas +3 more

A Universal and High-Throughput Proteomics Sample Preparation Platform

Analytical Chemistry(2021)10.1021/acs.analchem.1c00265

N/A

0DataRank · unranked

47 citations

Yaqin Zhang, Tuan Xu, Zhengxi Wei, Qin Yao, Yuhong Fang +8 more

Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

Drug Metabolism and Disposition(2021)10.1124/dmd.120.000320

N/A

0DataRank · unranked

40 citations

Sankalp Jain, Pranav Shah, Nao Torimoto‐Katori, Alexey Zakharov, Ðắc-Trung Nguyễn +8 more

High‐throughput screening assays for SARS‐CoV‐2 drug development: Current status and future directions

Drug Discovery Today(2021)10.1016/j.drudis.2021.05.012

N/A

0DataRank · unranked

35 citations

Wei Zheng, Ruili Huang, Tuan Xu

Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.1c00439

N/A

0DataRank · unranked

27 citations

Jinghua Zhao, Menghang Xia, Huixiao Hong, Anton Simeonov, Iosif I. Vaisman +2 more

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127906

N/A

0DataRank · unranked

24 citations

Miao Xu, Xin Hu, Emily M. Lee, Xiao Lü, Ruili Huang +19 more

Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules

Methods in molecular biology(2021)10.1007/7651_2021_394

N/A

0DataRank · unranked

10 citations

Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang +9 more

Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium

PLoS neglected tropical diseases(2021)10.1371/journal.pntd.0009432

N/A

0DataRank · unranked

3 citations

Ulrich Fabien Prodjinotho, Nagwa Elkhafif, Ruili Huang, Anton Simeonov, Thomas Spangenberg +2 more

Correction to: Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules

Methods in molecular biology(2021)10.1007/7651_2021_458

N/A

0DataRank · unranked

1 citations

Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang +9 more

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data

Toxicology and Applied Pharmacology(2022)10.1016/j.taap.2022.116250

N/A

0DataRank · unranked

44 citations

Deborah K. Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, Srilatha Sakamuru +6 more

A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling

Methods in molecular biology(2022)10.1007/978-1-0716-2213-1_13

N/A

0DataRank · unranked

22 citations

Ruili Huang

Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c01372

N/A

0DataRank · unranked

26 citations

Miao Xu, Wei Zhu, Catherine Z. Chen, Qi Zhang, Wei Zheng +2 more

Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation

Archives of Toxicology(2022)10.1007/s00204-022-03291-5

N/A

0DataRank · unranked

24 citations

Jinghua Zhao, Pranav Shah, Jameson Travers, Carleen Klumpp‐Thomas, Xin Xu +7 more

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

JCI Insight(2022)10.1172/jci.insight.153868

N/A

0DataRank · unranked

10 citations

Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Srilatha Sakamuru +10 more

Ruili Huang

Indexed papers

Top data-sharing exemplar

Papers