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Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127906Source: DataRank Database

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection is a research paper published in Bioorganic & Medicinal Chemistry Letters (2021). On theSindex it has a DataRank of 0. It has been cited 24 times.

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0DataRank · unranked

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Open Access24 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 3.22)OA: greenTopics (67)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (24)

Miao Xu ORCID,Xin Hu ORCID,Emily M. Lee ORCID,Xiao Lü ORCID,Ruili Huang ORCID

Live enrichment

PubMed:33689873 PMC:PMC7936759 OpenAlex:https://openalex.org/W3135268658

NIAID NIH HHS

Grant: U19 AI131130

NIAID NIH HHS

Grant: R01 AI146342

National Institutes of Health

Grant: 5U19AI131130-04

Engineering a human brain organoid-based platform to study neurotropic viruses

National Institutes of Health

FWCI

3.22

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7936759

publisherhttps://api.elsevier.com/content/article/PII:S0960894X21001323?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X21001323?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmcl.2021.127906

Fields of Study

Mosquito-borne diseases and controlViral Infections and VectorsVirology and Viral Diseases0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Zika VirusViral ProteasesSARS-CoV-2AnimalsAntiviral AgentsBinding SitesChlorocebus aethiopsDrug StabilityHumansMicrobial Sensitivity TestsMicrosomes, LiverNiclosamideProtein BindingSerine EndopeptidasesStructure-Activity RelationshipVero CellsViral ProteinsMolecular StructureViral Nonstructural ProteinsNucleoside-TriphosphataseRatsDEAD-box RNA HelicasesMolecular Docking Simulation

Keywords

NiclosamideDrug repositioningChemistryDrugZika virusRepurposingPharmacologyProbenecidPotencyVirologyVirusBiochemistryMedicineIn vitroBiologySalicylanilideFlavivirusSmall MoleculeNs-1 AssayBinding SitesMolecular StructureSARS-CoV-2Serine EndopeptidasesMicrobial Sensitivity TestsViral Nonstructural ProteinsAntiviral AgentsArticleRatsMolecular Docking SimulationStructure-Activity RelationshipViral ProteinsDrug StabilityChlorocebus aethiopsMicrosomes, LiverAnimalsHumansVero CellsProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

FAIR Checklist

Authors (24)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)