Hiroaki Mitsuya

National Center for Global Health and Medicine

Also affiliated with National Cancer Institute, Kumamoto University

MedicineImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 46 papers. Top paper: “Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2”.

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Nature(2022)10.1038/s41586-022-04856-1

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10.7DataRank · unranked

293 citations

Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda +64 more

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature Communications(2021)10.1038/s41467-021-20900-6

N/A

0.792DataRank · unranked

196 citations

Nobuyo Higashi‐Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut +18 more

Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement

Chemical and Pharmaceutical Bulletin(2023)10.1248/cpb.c23-00562

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0.330DataRank · unranked

8 citations

Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi‐Kuwata, Chika Azuma, Kouki Shinohara +8 more

HIV-1 resistance to islatravir/tenofovir combination therapy in wild-type or NRTI resistant strains of diverse HIV-1 subtypes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.18.545484

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0.208DataRank · unranked

3 citations

Xin Wen, Aaron B. Reeve, Obiaara Ukah, Alexa A. Snyder, Ciro M. Carrillo +10 more

Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication

RSC Medicinal Chemistry(2024)10.1039/d4md00454j

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0.208DataRank · unranked

3 citations

Ashwin Nair, Yana Astter, Emma Treco, Brian D. Peyser, Rick Gussio +10 more

Pharmacokinetics of 4′-cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease

Journal of Infection and Chemotherapy(2020)10.1016/j.jiac.2020.12.014

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0DataRank · unranked

0 citations

Kazuaki Taguchi, Shuhei Imoto, Keishi Yamasaki, Hiroaki Mitsuya, Masaki Otagiri +1 more

Characterization of a new SARS-CoV-2 variant that emerged in Brazil

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2106535118

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0DataRank · unranked

87 citations

Peter Halfmann, Seiya Yamayoshi, Kiyoko Iwatsuki‐Horimoto, S. Chiba, Tokiko Watanabe +54 more

Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals

Scientific Reports(2021)10.1038/s41598-021-01930-y

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69 citations

Masayuki Amano, Yukari Uemura, K. Tsuchiya, Tomoko Matsushima, Kenta Noda +17 more

Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters

Journal of Virology(2021)10.1128/jvi.01551-21

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0DataRank · unranked

26 citations

Masaki Imai, Kenji Maeda, Noriko Nakajima, Nobuyo Higashi‐Kuwata, Kiyoko Iwatsuki‐Horimoto +9 more

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Molecules(2021)10.3390/molecules26195782

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14 citations

Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy +8 more

Correlates of Neutralizing/SARS-CoV-2-S1-binding Antibody Response with Adverse Effects and Immune Kinetics in BNT162b2-Vaccinated Individuals

Research Square(2021)10.21203/rs.3.rs-847396/v1

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16 citations

Masayuki Amano, Yukari Uemura, K. Tsuchiya, Tomoko Matsushima, Kenta Noda +17 more

Correlates of Neutralizing/SARS-CoV-2-S1-binding Antibody Response with Adverse Effects and Immune Kinetics in BNT162b2-Vaccinated Individuals

medRxiv(2021)10.1101/2021.07.27.21261237

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0DataRank · unranked

9 citations

Masayuki Amano, Yukari Uemura, K. Tsuchiya, Tomoko Matsushima, Kenta Noda +17 more

Mathematical Epidemiological Model of the Propagation and Prevention of Infectious Diseases Considering COVID-19 Vaccination

Research Square(2021)10.21203/rs.3.rs-709496/v1

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0DataRank · unranked

0 citations

Hiroaki Mitsuya, Kazumi Omata

Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance

Chemical Communications(2022)10.1039/d2cc04541a

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0DataRank · unranked

24 citations

Irene T. Weber, Hiroaki Mitsuya, Arun K. Ghosh

Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variants

Scientific Reports(2022)10.1038/s41598-022-17071-9

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0DataRank · unranked

10 citations

Sachiko Otsu, Kenji Maeda, Yukari Uemura, Yosuke Shimizu, Kazumi Omata +4 more

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Antimicrobial Agents and Chemotherapy(2022)10.1128/aac.01715-21

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0DataRank · unranked

9 citations

Ravikiran S. Yedidi, Pedro Miguel Salcedo-Gómez, Hironori Hayashi, Kazuya Hasegawa, Cuthbert D. Martyr +3 more

Third-Dose BNT162b2 Vaccination Elicits Markedly High-Level SARS-CoV-2–Neutralizing Antibodies in Vaccinees Who Responded Poorly to a Second Dose in Japan

The Journal of Infectious Diseases(2022)10.1093/infdis/jiac209

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0DataRank · unranked

9 citations

Kenji Maeda, K. Tsuchiya, Shinya Shimada, Hiroaki Mitsuya, Masayuki Amano

Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine

The Journal of Infectious Diseases(2022)10.1093/infdis/jiac393

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0DataRank · unranked

8 citations

Sachiko Otsu, Yasuko Ichikawa, Nobuyo Higashi‐Kuwata, Shuzo Matsushita, Shinya Shimada +2 more

Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands

ChemMedChem(2022)10.1002/cmdc.202200058

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0DataRank · unranked

6 citations

Satish Kovela, Ashish Sharma, Dana Shahabi, Ajay K. Ghosh, Denver R. Hopkins +11 more

Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters

Journal of Pharmacological Sciences(2022)10.1016/j.jphs.2022.09.002

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0DataRank · unranked

1 citations

Hirofumi Hashimoto, Meika Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito +6 more

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Nature Communications(2023)10.1038/s41467-023-36729-0

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0DataRank · unranked

45 citations

Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai +30 more

Neutralization activity of IgG antibody in COVID‑19‑convalescent plasma against SARS-CoV-2 variants

Scientific Reports(2023)10.1038/s41598-023-28591-3

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0DataRank · unranked

18 citations

Kenji Maeda, Kouki Matsuda, Yuki Takamatsu, Noriko Kinoshita, Satoshi Kutsuna +6 more

SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129489

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0DataRank · unranked

12 citations

Dana Shahabi, Mackenzie E.C. Imhoff, Satish Kovela, Ashish Sharma, Shin-ichiro Hattori +4 more

A novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associated cellular marker perturbation in human hepatocytes

Virus Research(2023)10.1016/j.virusres.2023.199094

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0DataRank · unranked

8 citations

Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya +2 more

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115449

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0DataRank · unranked

10 citations

Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata +6 more

Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129168

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0DataRank · unranked

8 citations

Dana Shahabi, Maya Kipfmiller, Ajay K. Ghosh, Megan Johnson, Yuan-Fang Wang +5 more

Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115385

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0DataRank · unranked

5 citations

Jennifer L. Mishevich, Satish Kovela, Ryan Shaktah, Ajay K. Ghosh, Megan Johnson +9 more

Comparison of neutralization activity against Omicron BA.2/BA.5 in sera from HCWs receiving heterologous/homologous COVID-19 vaccines

Journal of Infection(2023)10.1016/j.jinf.2023.01.038

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0DataRank · unranked

4 citations

Yasuko Ichikawa, Yukari Uemura, Shota Matsumoto, Kenji Maeda, Shuzo Matsushita +3 more

Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

RSC Advances(2023)10.1039/d3ra01750h

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0DataRank · unranked

2 citations

Nobuyo Higashi‐Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda +9 more

Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation

Synlett(2023)10.1055/s-0043-1763629

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0DataRank · unranked

0 citations

Hiroki Kumamoto, Shuhei Imoto, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya, Kazuhiro Haraguchi

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116132

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0DataRank · unranked

15 citations

Monika Yadav, Iddum Satyanarayana, Somayeh Ghazi, Emma K. Lendy, Uttara Jayashankar +8 more

Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2404175121

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0DataRank · unranked

15 citations

Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa +10 more

An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

PNAS Nexus(2024)10.1093/pnasnexus/pgae578

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9 citations

Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso +23 more

High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with in vitro viral neutralizing activity

Heliyon(2024)10.1016/j.heliyon.2024.e24513

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0DataRank · unranked

5 citations

Yuki Takamatsu, Yusuke Asai, K. Tsuchiya, Kouki Matsuda, Yusuke Oshiro +10 more

Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies

Organic & Biomolecular Chemistry(2024)10.1039/d4ob00506f

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0DataRank · unranked

2 citations

Daniel Lee, Ashish Sharma, Megan Johnson, Ajay K. Ghosh, Yuan-Fang Wang +6 more

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01520

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0DataRank · unranked

4 citations

Jyoti Vishwakarma, Katharina Sylvester, Nobuyo Higashi‐Kuwata, Agnieszka Dąbrowska, Renee Delgado +16 more

Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity

Virus Research(2025)10.1016/j.virusres.2025.199615

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0DataRank · unranked

3 citations

Mariko Kato, Shin-ichiro Hattori, Yuki Takamatsu, Hiroaki Mitsuya, Nobuyo Higashi‐Kuwata

SARS-CoV-2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

ACS Omega(2025)10.1021/acsomega.5c05856

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0DataRank · unranked

2 citations

Takuya Kobayakawa, Kohei Tsuji, Yuki Takamatsu, Hiroaki Mitsuya, Hirokazu Tamamura +1 more

Potent HIV‑1 protease inhibitors containing oxabicyclo octanol-derived P2-ligands: Design, synthesis, and X‑ray structural studies of inhibitor-HIV-1 protease complexes

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130109

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0DataRank · unranked

3 citations

Monika Yadav, Ashish Sharma, Megan Johnson, Ajay K. Ghosh, Rangu Prasad +5 more

Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117880

N/A

0DataRank · unranked

0 citations

Ryan Shaktah, Ajay K. Ghosh, Megan Johnson, Dipendra Bhandari, Masayuki Amano +4 more

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Scientific Reports(2020)10.1038/s41598-020-65993-z

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0DataRank · unranked

82 citations

Shin‐ichiro Hattori, Hiromi Aoki-Ogata, Hironori Hayashi, Debananda Das, Manabu Aoki +6 more

SARS-CoV-2 Main Protease Inhibitors Containing 5-Substituted Benzothiazole-2-carbonyl Moieties at the P1′ Site and Their Derivatives

ACS Omega(2025)10.1021/acsomega.5c05168

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0DataRank · unranked

0 citations

Takuya Kobayakawa, Nobuyo Higashi‐Kuwata, Takahiro Ishii, Kouki Shinohara, Ryusei Yamamoto +5 more

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

mBio(2020)10.1128/mbio.01833-20

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0DataRank · unranked

79 citations

Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, David A. Davis +11 more

Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Journal of Hepatology(2020)10.1016/j.jhep.2020.12.006

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0DataRank · unranked

28 citations

Sanae Hayashi, Hiroki Kumamoto, Hiromi Ogata-Aoki, Debananda Das, David Venzon +12 more

7-Deaza-7-fluoro modification confers on 4′-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

Antiviral Research(2020)10.1016/j.antiviral.2020.104744

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0DataRank · unranked

7 citations

Nobuyo Higashi‐Kuwata, Debananda Das, Kota Tomaya, Kohei Yamada, Shuko Murakami +7 more

Pharmacokinetic Properties of Orally Administered 4′-Cyano-2′-deoxyguanosine, a Novel Nucleoside Analog Inhibitor of the Hepatitis B Virus, in Viral Liver Injury Model Rats

Biological and Pharmaceutical Bulletin(2020)10.1248/bpb.b20-00372

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2 citations

Kazuaki Taguchi, Shuhei Imoto, Keishi Yamasaki, Hiroaki Mitsuya, Masaki Otagiri +1 more