Issam Ben‐Sahra

Biochemistry, Genetics and Molecular BiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 28 papers. Top paper: “Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages”.

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Nature Metabolism(2020)10.1038/s42255-020-00305-3

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0DataRank · unranked

413 citations

Abhijit Kale, Rosalba Perrone, José A López-Domínguez, Angela Oliveira Pisco, Herbert G. Kasler +26 more

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

Molecular Cell(2020)10.1016/j.molcel.2020.05.001

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74 citations

Umakant Sahu, Elodie Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet +4 more

mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

Molecular Cell(2021)10.1016/j.molcel.2021.03.009

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179 citations

Umakant Sahu, Brendan P. O’Hara, Eunüs S. Ali, Kathryn A. Helmin, John M. Asara +4 more

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

Molecular Metabolism(2021)10.1016/j.molmet.2021.101309

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37 citations

Yann Cormerais, Krystle C. Kalafut, Víctor Barrera, James E Hughes Hallett, Shannan Ho Sui +6 more

mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion

Brain(2021)10.1093/brain/awab451

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9 citations

Miriam C. Aziz, Hannah C. Happ, Jonathan Gunti, Colleen Gleason, Najma Mohamed +24 more

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.02.442369

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4 citations

Yann Cormerais, Krystle C. Kalafut, Víctor Barrera, James E Hughes Hallett, Shannan Ho Sui +6 more

The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.10.468146

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1 citations

Alexander R. Terry, Medha Priyadarshini, Grace Guzman, José Córdoba‐Chacón, Issam Ben‐Sahra +3 more

Determining the pathogenicity of variants of uncertain significance and identification of a founder variant in the epilepsy-associated gene, SZT2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.06.425612

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0DataRank · unranked

0 citations

Miriam C. Aziz, Hannah C. Happ, Jonathan Gunti, Colleen Gleason, Najma Mohamed +24 more

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

Nature Communications(2022)10.1038/s41467-022-30362-z

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86 citations

R. Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari +16 more

The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

Molecular Cell(2022)10.1016/j.molcel.2022.06.008

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41 citations

Anna Lipońska, Brendan P. O’Hara, David R. Amici, Michael D. Torno, Peng Gao +5 more

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2111262119

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24 citations

Daniel J. Ansel, Kyle Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri +14 more

Iron Drives Anabolic Metabolism Through Active Histone Demethylation and mTORC1

Research Square(2022)10.21203/rs.3.rs-2042947/v1

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1 citations

Hsiang‐Chun Chang, Zibo Zhao, Zohra Waxali, Bong Jin Hong, Haimei Chen +21 more

Regulation of nucleotide metabolism in cancers and immune disorders

Trends in Cell Biology(2023)10.1016/j.tcb.2023.03.003

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118 citations

Issam Ben‐Sahra, Eunüs S. Ali

Iron drives anabolic metabolism through active histone demethylation and mTORC1

Nature Cell Biology(2023)10.1038/s41556-023-01225-6

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41 citations

Hsiang‐Chun Chang, Yuki Tatekoshi, Zibo Zhao, Zohra Sattar Waxali, Bong Jin Hong +23 more

Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models

European Heart Journal(2023)10.1093/eurheartj/ehad044

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29 citations

Qiuhua Yang, Jiean Xu, Hunter Sellers, Zachary Brown, Zhiping Liu +20 more

Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations

Journal of Clinical Investigation(2023)10.1172/jci169993

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19 citations

Kaixiang Cao, Jun Watanabe, Cassandra N. Philips, Jacob M. Zeidner, Yukitomo Ishi +10 more

Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

JCI Insight(2023)10.1172/jci.insight.166956

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12 citations

Hongyan Ning, Norrina B. Allen, Mercedes R. Carnethon, Amisha Wallia, James D. Otvos +5 more

The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment

Cell Death and Disease(2023)10.1038/s41419-023-06275-0

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10 citations

Yongjian Guo, A. Mazzu, Marie Irondelle, Matthieu Rouleau, Chiara Lago +6 more

GATOR2 rings GATOR1 to speak to mTORC1

Molecular Cell(2023)10.1016/j.molcel.2022.12.011

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7 citations

Issam Ben‐Sahra, Umakant Sahu

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

Molecular Cancer Therapeutics(2023)10.1158/1535-7163.mct-23-0258

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2 citations

Eunüs S. Ali, Marcela Krečmerová, Joanna Marie H. Aguilar, Jesse Alt, Diane E. Peters +11 more

Mechano-dependent sorbitol accumulation supports biomolecular condensate

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.24.550444

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5 citations

William M. Oldham, Andrés R. Tejedor, Ignacio Sanchez‐Burgos, Nesrine Rachedi, Kéren Fraissard +11 more

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.17.562750

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0 citations

Yongjian Guo, Magalie Larcher, Liliana Mirabal-Ortega, Matthieu Rouleau, Marie Irondelle +13 more

Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis

Science(2024)10.1126/science.adh2771

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70 citations

Elodie Villa, Colleen R. Reczek, Zibo Zhao, Brendan P. O’Hara, Michael D. Torno +8 more

Mechano-dependent sorbitol accumulation supports biomolecular condensate

Cell(2024)10.1016/j.cell.2024.10.048

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30 citations

William M. Oldham, Andrés R. Tejedor, Ignacio Sanchez‐Burgos, Lara Nasr, Nesrine Rachedi +13 more

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

Cell Death Discovery(2024)10.1038/s41420-024-02100-5

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5 citations

Yongjian Guo, Magalie Larcher, Liliana Mirabal-Ortega, Matthieu Rouleau, Marie Irondelle +13 more

Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2424046122

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16 citations

Abhishek Vijay Thakkar, Adam W. T. Steffeck, Eric M. Pfrender, Kaitlyn Hung, Pei Zhu +9 more

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

Molecular Cell(2025)10.1016/j.molcel.2025.10.002

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8 citations

Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel J. McGrail +9 more

Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation

Molecular Cell(2025)10.1016/j.molcel.2025.11.009

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2 citations

Daniela Samaniego-Castruita, Sakshi Khurana, Jalees Rehman, Vipul Shukla, Issam Ben‐Sahra +2 more