Hyunbum Jang

Frederick National Laboratory for Cancer Research

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 88 papers. Top paper: “Anticancer drug resistance: An update and perspective”.

Anticancer drug resistance: An update and perspective

Drug Resistance Updates(2021)10.1016/j.drup.2021.100796

N/A

0.891DataRank · unranked

379 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

PI3K inhibitors: review and new strategies

Chemical Science(2020)10.1039/d0sc01676d

N/A

0.787DataRank · unranked

189 citations

Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

A new precision medicine initiative at the dawn of exascale computing

Signal Transduction and Targeted Therapy(2021)10.1038/s41392-020-00420-3

N/A

0.604DataRank · unranked

55 citations

Hyunbum Jang, Guy Nir, Chung‐Jung Tsai, Feixiong Cheng, Ruth Nussinov

Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.09.002

N/A

0.581DataRank · unranked

47 citations

Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

The mechanism of activation of MEK1 by B-Raf and KSR1

Cellular and Molecular Life Sciences(2022)10.1007/s00018-022-04296-0

N/A

0.553DataRank · unranked

39 citations

Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Ryan Maloney

Cell phenotypes can be predicted from propensities of protein conformations

Current Opinion in Structural Biology(2023)10.1016/j.sbi.2023.102722

N/A

0.529DataRank · unranked

33 citations

Yonglan Liu, Wengang Zhang, Hyunbum Jang, Ruth Nussinov

Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance

The Annual Review of Pharmacology and Toxicology(2023)10.1146/annurev-pharmtox-022823-113946

N/A

0.515DataRank · unranked

30 citations

Hyunbum Jang, Ruth Nussinov

Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics

The Journal of Physical Chemistry B(2021)10.1021/acs.jpcb.1c00891

N/A

0.494DataRank · unranked

26 citations

Nurcan Tunçbağ, Hyunbum Jang, Ruth Nussinov, Attila Gürsoy, Özlem Keskin +1 more

The value of protein allostery in rational anticancer drug design: an update

Expert Opinion on Drug Discovery(2024)10.1080/17460441.2024.2384467

N/A

0.489DataRank · unranked

25 citations

Hyunbum Jang, Ruth Nussinov

Allostery in Disease: Anticancer Drugs, Pockets, and the Tumor Heterogeneity Challenge

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169050

N/A

0.482DataRank · unranked

15 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia

Biophysical Journal(2022)10.1016/j.bpj.2022.05.030

N/A

0.477DataRank · unranked

23 citations

Hyunbum Jang, Mingzhen Zhang, Chung‐Jung Tsai, Ryan Maloney, Ruth Nussinov +1 more

The structural basis of Akt PH domain interaction with calmodulin

Biophysical Journal(2021)10.1016/j.bpj.2021.03.018

N/A

0.477DataRank · unranked

23 citations

Hyunbum Jang, Özlem Keskin, Ruth Nussinov, Attila Gürsoy, Jackson Weako

Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain

Journal of Molecular Biology(2023)10.1016/j.jmb.2023.168354

N/A

0.464DataRank · unranked

21 citations

Jiaye Chen, Lilia M. Iakoucheva, Ruth Nussinov, Hyunbum Jang

Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination

Advanced Science(2023)10.1002/advs.202303367

N/A

0.464DataRank · unranked

21 citations

Paolo Carai, Tonči Ivanišević, Mingzhen Zhang, Hyunbum Jang, Benoit Lechat +6 more

Kinase signaling cascades: an updated mechanistic landscape

Chemical Science(2025)10.1039/d5sc04657b

N/A

0.442DataRank · unranked

18 citations

Clil Regev, Hyunbum Jang, Ruth Nussinov

K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins

The EMBO Journal(2024)10.1038/s44318-024-00146-w

N/A

0.434DataRank · unranked

17 citations

Mikhail Steklov, Hyunbum Jang, Raj Nayan Sewduth, Amir Florentin, Benoit Lechat +7 more

Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide

Frontiers in Cell and Developmental Biology(2024)10.3389/fcell.2024.1376639

N/A

0.416DataRank · unranked

15 citations

Bengi Ruken Yavuz, Habibe Cansu Demirel, M. Kaan Arici, Hyunbum Jang, Nurcan Tunçbağ +1 more

Tumor-derived RHOA mutants interact with effectors in the GDP-bound state

Nature Communications(2024)10.1038/s41467-024-51445-z

N/A

0.402DataRank · unranked

7 citations

Theresa A. Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov +3 more

Binding Modalities and Phase-Specific Regulation of Cyclin/Cyclin-Dependent Kinase Complexes in the Cell Cycle

The Journal of Physical Chemistry B(2024)10.1021/acs.jpcb.4c03243

N/A

0.385DataRank · unranked

12 citations

Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Michael T. Bergman

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.16.553605

N/A

0.373DataRank · unranked

11 citations

Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Wengang Zhang

ERK Allosteric Activation: The Importance of Two Ordered Phosphorylation Events

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169130

N/A

0.330DataRank · unranked

8 citations

Hyunbum Jang, Ruth Nussinov, Clil Regev

Allostery in Biomolecular Condensates

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169446

N/A

0.269DataRank · unranked

5 citations

Clil Regev, Hyunbum Jang, Ruth Nussinov

Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family

Familial Cancer(2021)10.1007/s10689-021-00267-9

N/A

0.241DataRank · unranked

4 citations

Mai Xu, Michael R. Sargen, Hyunbum Jang, Mingzhen Zhang, Tongwu Zhang +24 more

Neurodevelopmental disorders and cancer networks share pathways; but differ in mechanisms, signaling strength, and outcome

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.16.536718

N/A

0.165DataRank · unranked

2 citations

M. Kaan Arici, Habibe Cansu Demirel, Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov +2 more

Cellular Mechanisms Underlying Melanoma Brain Metastasis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.24.689301

N/A

0.104DataRank · unranked

1 citations

Hyunbum Jang, Ruth Nussinov, Bengi Ruken Yavuz

Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family

medRxiv(2021)10.1101/2021.04.20.21254596

N/A

0.104DataRank · unranked

1 citations

Mai Xu, Michael R. Sargen, Hyunbum Jang, Mingzhen Zhang, Tongwu Zhang +24 more

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Journal of Molecular Biology(2022)10.1016/j.jmb.2022.167569

N/A

0DataRank · unranked

69 citations

Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Chung‐Jung Tsai, Hyunbum Jang +1 more

A New View of Activating Mutations in Cancer

Cancer Research(2022)10.1158/0008-5472.can-22-2125

N/A

0DataRank · unranked

39 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Allosteric regulation of autoinhibition and activation of c-Abl

Computational and Structural Biotechnology Journal(2022)10.1016/j.csbj.2022.08.014

N/A

0DataRank · unranked

32 citations

Mingzhen Zhang, Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov, Yonglan Liu

Allostery, and how to define and measure signal transduction

Biophysical Chemistry(2022)10.1016/j.bpc.2022.106766

N/A

0DataRank · unranked

46 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Neurodevelopmental disorders, immunity, and cancer are connected

iScience(2022)10.1016/j.isci.2022.104492

N/A

0DataRank · unranked

35 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Conformational Dynamics Allows Sampling of an “Active-like” State by Oncogenic K-Ras-GDP

Journal of Molecular Biology(2022)10.1016/j.jmb.2022.167695

N/A

0DataRank · unranked

30 citations

Hyunbum Jang, Nicholas Leschinsky, Ruth Nussinov, Vadim Gaponenko, Patrick Grudzien

Higher‐order interactions of Bcr‐Abl can broaden chronic myeloid leukemia (CML) drug repertoire

Protein Science(2022)10.1002/pro.4504

N/A

0DataRank · unranked

20 citations

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov, Yonglan Liu

Activation mechanisms of clinically distinct B‐Raf V600E and V600K mutants

Cancer Communications(2022)10.1002/cac2.12395

N/A

0DataRank · unranked

13 citations

Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

The Mechanism of Activation of MEK1 by B-Raf and KSR1

Research Square(2022)10.21203/rs.3.rs-1412459/v1

N/A

0DataRank · unranked

0 citations

Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Ryan Maloney

Protein conformational ensembles in function: roles and mechanisms

RSC Chemical Biology(2023)10.1039/d3cb00114h

N/A

0DataRank · unranked

101 citations

Yonglan Liu, Wengang Zhang, Hyunbum Jang, Ruth Nussinov

AlphaFold, allosteric, and orthosteric drug discovery: Ways forward

Drug Discovery Today(2023)10.1016/j.drudis.2023.103551

N/A

0DataRank · unranked

93 citations

Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov

Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK

Biophysical Reviews(2023)10.1007/s12551-023-01054-9

N/A

0DataRank · unranked

52 citations

Bengi Ruken Yavuz, M. Kaan Arici, Habibe Cansu Demirel, Mingzhen Zhang, Yonglan Liu +4 more

Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome

npj Genomic Medicine(2023)10.1038/s41525-023-00377-6

N/A

0DataRank · unranked

39 citations

M. Kaan Arici, Habibe Cansu Demirel, Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov +2 more

Strategy toward Kinase-Selective Drug Discovery

Journal of Chemical Theory and Computation(2023)10.1021/acs.jctc.2c01171

N/A

0DataRank · unranked

32 citations

Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities

Cellular and Molecular Life Sciences(2023)10.1007/s00018-023-05052-8

N/A

0DataRank · unranked

25 citations

Wengang Zhang, Hyunbum Jang, Ruth Nussinov, Yonglan Liu

The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization

Chemical Science(2023)10.1039/d3sc04690g

N/A

0DataRank · unranked

24 citations

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov, Yonglan Liu

Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus

Frontiers in Molecular Biosciences(2023)10.3389/fmolb.2023.1111574

N/A

0DataRank · unranked

6 citations

Pedro T. Resende-Lara, Bálint Dudás, Hyunbum Jang, David Pérahia, Ruth Nussinov +2 more

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.26.525746

N/A

0DataRank · unranked

7 citations

Jiaye Chen, Lilia M. Iakoucheva, Ruth Nussinov, Hyunbum Jang

Molecular Mechanism of Regulation of RhoA GTPase by Phosphorylation of RhoGDI

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.10.540210

N/A

0DataRank · unranked

0 citations

Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty, Krishnendu Sinha

Anticancer drugs: How to select small molecule combinations?

Trends in Pharmacological Sciences(2024)10.1016/j.tips.2024.04.012

N/A

0DataRank · unranked

29 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Slower CDK4 and faster CDK2 activation in the cell cycle

Structure(2024)10.1016/j.str.2024.04.012

N/A

0DataRank · unranked

21 citations

Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Wengang Zhang

Single cell spatial biology over developmental time can decipher pediatric brain pathologies

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106597

N/A

0DataRank · unranked

12 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Ras, RhoA, and vascular pharmacology in neurodevelopment and aging

Neurochemistry International(2024)10.1016/j.neuint.2024.105883

N/A

0DataRank · unranked

3 citations

Hyunbum Jang, Feixiong Cheng, Ruth Nussinov

Disruption of Ca 2+ /calmodulin: KSR1 interaction lowers ERK activation

Protein Science(2024)10.1002/pro.4982

N/A

0DataRank · unranked

4 citations

Hyunbum Jang, Zhigang Li, Samar Sayedyahossein, Ryan Maloney, Ruth Nussinov +2 more

Co-occurring Mutations in Different Genes Can Fuel Oncogenic Signaling and Serve as Metastatic Tumor Markers

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.01.592039

N/A

0DataRank · unranked

1 citations

Uğur Şahin, Hyunbum Jang, Ruth Nussinov, Nurcan Tunçbağ, Bengi Ruken Yavuz

Molecular principles underlying aggressive cancers

Signal Transduction and Targeted Therapy(2025)10.1038/s41392-025-02129-7

N/A

0DataRank · unranked

69 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Allostery: allosteric networks and allosteric signaling bias

Quarterly Reviews of Biophysics(2025)10.1017/s0033583525100061

N/A

0DataRank · unranked

14 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Drug resistance and tumor heterogeneity: cells and ensembles

Biophysical Reviews(2025)10.1007/s12551-025-01320-y

N/A

0DataRank · unranked

13 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Discovering anticancer drug target combinations via network-informed signaling-based approach

Communications Medicine(2025)10.1038/s43856-025-01150-9

N/A

0DataRank · unranked

7 citations

Hyunbum Jang, Ruth Nussinov, Bengi Ruken Yavuz

How residence time works in allosteric drugs

Current Opinion in Structural Biology(2025)10.1016/j.sbi.2025.103149

N/A

0DataRank · unranked

6 citations

Hyunbum Jang, Ruth Nussinov

Distinct Allosteric Networks in CDK4 and CDK6 in the Cell Cycle and in Drug Resistance

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169121

N/A

0DataRank · unranked

5 citations

Devin Bradburn, Gretchen Heidebrink, Yonglan Liu, Hyunbum Jang, Ruth Nussinov +2 more

M-Ras distinct activation scenarios: A mechanistic outlook and targeting

Computational and Structural Biotechnology Journal(2025)10.1016/j.csbj.2025.11.025

N/A

0DataRank · unranked

4 citations

Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Liang Xu

Reimagining computational macromolecular modeling: AI-driven approaches

Biophysical Journal(2025)10.1016/j.bpj.2025.11.028

N/A

0DataRank · unranked

3 citations

Hyunbum Jang, Ruth Nussinov, Özlem Keskin, Attila Gürsoy, E. Sıla Özdemir

Phosphorylation induces altered protonation states and allosterically regulates Rac1– RhoGDI complex

Protein Science(2025)10.1002/pro.70413

N/A

0DataRank · unranked

2 citations

Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty, Krishnendu Sinha

The structural heterogeneity of AKT autoinhibition

Protein Science(2025)10.1002/pro.70420

N/A

0DataRank · unranked

2 citations

Meryem Eren, Jackson Weako, Hyunbum Jang, Özlem Keskin, Attila Gürsoy +2 more

Tumors and their microenvironments: Learning from pediatric brain pathologies

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer(2025)10.1016/j.bbcan.2025.189328

N/A

0DataRank · unranked

3 citations

Bengi Ruken Yavuz, Hyunbum Jang, Ruth Nussinov

Molecular mechanism of regulation of RhoA GTPase by phosphorylation of RhoGDI

Biophysical Journal(2023)10.1016/j.bpj.2023.11.018

N/A

0DataRank · unranked

12 citations

Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty, Krishnendu Sinha

Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction

Biophysical Journal(2020)10.1016/j.bpj.2020.04.026

N/A

0DataRank · unranked

16 citations

Hyunbum Jang, Hannah A. Davies, Martin Niemiec, Joe G. N. Garcia, Ruth Nussinov +4 more

SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations

The Journal of Chemical Physics(2020)10.1063/5.0013926

N/A

0DataRank · unranked

23 citations

Hyunbum Jang, David Fushman, Ruth Nussinov, Tsung-Jen Liao

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.01.002

N/A

0DataRank · unranked

20 citations

Cihan Aydın, Ezgi Odabasi, E. Sıla Özdemir, Elif Nur Firat‐Karalar, Hyunbum Jang +6 more

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

Frontiers in Molecular Biosciences(2020)10.3389/fmolb.2020.00145

N/A

0DataRank · unranked

16 citations

Franci Merzel, Hyunbum Jang, Ruth Nussinov, David Pérahia, Erika Balog +1 more

RAS Signaling in the PI3K/AKT/MTOR Pathway

Biophysical Journal(2020)10.1016/j.bpj.2019.11.458

N/A

0DataRank · unranked

5 citations

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov

Ras assemblies and signaling at the membrane

Current Opinion in Structural Biology(2020)10.1016/j.sbi.2020.01.009

N/A

0DataRank · unranked

46 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

Molecular Cancer Research(2020)10.1158/1541-7786.mcr-20-0818

N/A

0DataRank · unranked

45 citations

Mingzhen Zhang, Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective

Cancer Research(2020)10.1158/0008-5472.can-20-0911

N/A

0DataRank · unranked

42 citations

Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

The Mystery of Rap1 Suppression of Oncogenic Ras

Trends in cancer(2020)10.1016/j.trecan.2020.02.002

N/A

0DataRank · unranked

39 citations

Hyunbum Jang, Mingzhen Zhang, Chung‐Jung Tsai, Anna Sablina, Ruth Nussinov

High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1

Journal of the American Chemical Society(2020)10.1021/jacs.9b10710

N/A

0DataRank · unranked

37 citations

Hyunbum Jang, Ruth Nussinov, David Fushman, Tsung-Jen Liao

Are Parallel Proliferation Pathways Redundant?

Trends in Biochemical Sciences(2020)10.1016/j.tibs.2020.03.013

N/A

0DataRank · unranked

33 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics

Biophysical Journal(2020)10.1016/j.bpj.2020.12.007

N/A

0DataRank · unranked

31 citations

Hyunbum Jang, Ruth Nussinov, Nurit Haspel

The structural basis of the oncogenic mutant K-Ras4B homodimers

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.07.285783

N/A

0DataRank · unranked

2 citations

Meltem Eda Omur, Hyunbum Jang, Ruth Nussinov, Özlem Keskin, Attila Gürsoy +1 more

The mechanism of activation of monomeric B-Raf V600E

Computational and Structural Biotechnology Journal(2021)10.1016/j.csbj.2021.06.007

N/A

0DataRank · unranked

83 citations

Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov, Ryan Maloney

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

iScience(2021)10.1016/j.isci.2021.102438

N/A

0DataRank · unranked

64 citations

Iris Nira Smith, Charis Eng, Ruth Nussinov, Hyunbum Jang

The mechanism of Raf activation through dimerization

Chemical Science(2021)10.1039/d1sc03444h

N/A

0DataRank · unranked

57 citations

Ryan Maloney, Hyunbum Jang, Ruth Nussinov, Mingzhen Zhang

B-Raf autoinhibition in the presence and absence of 14-3-3

Structure(2021)10.1016/j.str.2021.02.005

N/A

0DataRank · unranked

54 citations

Hyunbum Jang, Zhigang Li, David B. Sacks, Ruth Nussinov, Mingzhen Zhang

Mechanistic Differences of Activation of Rac1P29S and Rac1A159V

The Journal of Physical Chemistry B(2021)10.1021/acs.jpcb.1c00883

N/A

0DataRank · unranked

34 citations

Hyunbum Jang, Ruth Nussinov, Özlem Keskin, Attila Gürsoy, Simge Senyuz

Inhibition of Nonfunctional Ras

Cell chemical biology(2021)10.1016/j.chembiol.2020.12.012

N/A

0DataRank · unranked

31 citations

Hyunbum Jang, Attila Gürsoy, Özlem Keskin, Vadim Gaponenko, Ruth Nussinov

Mechanism of activation and the rewired network: New drug design concepts

Medicinal Research Reviews(2021)10.1002/med.21863

N/A

0DataRank · unranked

30 citations

Mingzhen Zhang, Ryan Maloney, Chung‐Jung Tsai, Bengi Ruken Yavuz, Nurcan Tunçbağ +2 more

Signaling in the crowded cell

Current Opinion in Structural Biology(2021)10.1016/j.sbi.2021.05.009

N/A

0DataRank · unranked

27 citations

Chung‐Jung Tsai, Hyunbum Jang, Ruth Nussinov

Ras isoform-specific expression, chromatin accessibility, and signaling

Biophysical Reviews(2021)10.1007/s12551-021-00817-6

N/A

0DataRank · unranked

26 citations

Mingzhen Zhang, Ryan Maloney, Hyunbum Jang, Ruth Nussinov

The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations

Current Opinion in Structural Biology(2021)10.1016/j.sbi.2021.06.008

N/A

0DataRank · unranked

15 citations

Nicholas Leschinsky, Hyunbum Jang, Avik Banerjee, Ruth Nussinov, Vadim Gaponenko +1 more

Drugging multiple same-allele driver mutations in cancer

Expert Opinion on Drug Discovery(2021)10.1080/17460441.2021.1905628

N/A

0DataRank · unranked

14 citations

Mingzhen Zhang, Ryan Maloney, Hyunbum Jang, Ruth Nussinov

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.06.425565

N/A

0DataRank · unranked

2 citations

Iris Nira Smith, Charis Eng, Ruth Nussinov, Hyunbum Jang