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ERK Allosteric Activation: The Importance of Two Ordered Phosphorylation Events

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169130Source: DataRank Database

ERK Allosteric Activation: The Importance of Two Ordered Phosphorylation Events is a research paper published in Journal of Molecular Biology (2025). On theSindex it has a DataRank of 0.330. It has been cited 8 times.

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0.330DataRank · unranked

Scored on demand from live citation data

Open Access8 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 3.18)OA: hybridTopics (31)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.330

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (3)

Hyunbum Jang ORCID,Ruth Nussinov ORCID,Clil Regev ORCID

Live enrichment

PubMed:40216017 PMC:PMC12354100 OpenAlex:https://openalex.org/W4409307517

National Institutes of Health National Cancer Institute

Grant: HHSN261201500003I

Intramural NIH HHS

Grant: Z01 BC010440

Intramural NIH HHS

Grant: Z01 BC010441

Center for Cancer Research

U.S. Department of Health and Human Services

National Institutes of Health

FWCI

3.18

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.jmb.2025.169130

publisherhttps://doi.org/10.1016/j.jmb.2025.169130

publisherhttps://api.elsevier.com/content/article/PII:S0022283625001962?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022283625001962?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40216017

Fields of Study

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingComputational Drug Discovery MethodsPhosphorylationAllosteric RegulationMolecular Dynamics SimulationExtracellular Signal-Regulated MAP KinasesProtein ConformationEnzyme ActivationHumans

MeSH Terms

Allosteric RegulationEnzyme ActivationHumansPhosphorylationProtein ConformationExtracellular Signal-Regulated MAP KinasesMolecular Dynamics Simulation

Keywords

Allosteric regulationPhosphorylationMAPK/ERK pathwayChemistryCell biologyBiophysicsBiochemistryBiologyEnzymeMolecular dynamicsERK2Activation LoopDual Phosphorylation SitesSuccessive Phosphorylation