David W. Christianson

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 55 papers. Top paper: “Structure of a unique binuclear manganese cluster in arginase”.

Structure of a unique binuclear manganese cluster in arginase

Nature(1996)10.1038/383554a0

N/A

14.7DataRank · unranked

442 citations

Laura R. Scolnick, David E. Ash, David W. Christianson, Zoltan F. Kanyo

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors,

Biochemistry(2008)10.1021/bi801610c

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0.788DataRank · unranked

190 citations

Stephanie L. Gantt, Samuel G. Gattis, Carol A. Fierke, David W. Christianson, Daniel Dowling +1 more

Multicomponent Synthesis, Binding Mode, and Structure–Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b01888

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0DataRank · unranked

53 citations

Melf Sönnichsen, J.D. Osko, Andrea Schöler, Julian Schliehe‐Diecks, Alexander Jan Skerhut +7 more

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Nature Communications(2020)10.1038/s41467-020-17642-2

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0DataRank · unranked

47 citations

Guangkai Bian, Corey J. Herbst‐Gervasoni, Takahiro Mori, Stephen A. Shinsky, Anwei Hou +8 more

Higher-order oligomerization of a chimeric αβγ bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent

Journal of Structural Biology(2020)10.1016/j.jsb.2020.107463

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0DataRank · unranked

22 citations

Kushol Gupta, David W. Christianson, Trey A. Ronnebaum

Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders

Journal of Structural Biology(2020)10.1016/j.jsb.2020.107681

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0DataRank · unranked

9 citations

Nicholas J. Porter, Christophe Decroos, Matthew S. Lee, P. R. Watson, Sarah E. Raible +4 more

Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6

Acta Crystallographica Section F Structural Biology Communications(2020)10.1107/s2053230x20010250

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0DataRank · unranked

8 citations

David W. Christianson, J.D. Osko

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

ACS Medicinal Chemistry Letters(2020)10.1021/acsmedchemlett.0c00395

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0DataRank · unranked

42 citations

Nicola Relitti, Margherita Brindisi, J.D. Osko, Giulia Chemi, Stefano Federico +26 more

Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase

ACS Chemical Biology(2020)10.1021/acschembio.0c00362

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0DataRank · unranked

41 citations

Raphael R. Steimbach, Michael Morgen, Aubry K. Miller, David W. Christianson, Corey J. Herbst‐Gervasoni

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

ChemMedChem(2020)10.1002/cmdc.202000149

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0DataRank · unranked

38 citations

Raphael R. Steimbach, Magalie Géraldy, Lars Hellweg, Peter Sehr, Johannes Ridinger +9 more

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation

ChemRxiv(2020)10.26434/chemrxiv.12440096.v3

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0DataRank · unranked

6 citations

Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu +9 more

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation

ChemRxiv(2020)10.26434/chemrxiv.12440096

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0DataRank · unranked

1 citations

Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu +9 more

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

Nature Communications(2021)10.1038/s41467-021-23609-8

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0DataRank · unranked

95 citations

P. R. Watson, Timothy W. Craven, Xinting Li, Stephen Rettie, Fátima Pardo‐Ávila +13 more

Structural insight on assembly-line catalysis in terpene biosynthesis

Nature Communications(2021)10.1038/s41467-021-23589-9

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0DataRank · unranked

44 citations

Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. García, Kenji Murakami +2 more

Visualizing transiently associated catalytic domains in assembly-line biosynthesis using cryo-electron microscopy

Journal of Structural Biology(2021)10.1016/j.jsb.2021.107802

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0DataRank · unranked

7 citations

David W. Christianson, Jacque Faylo

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**

ChemBioChem(2022)10.1002/cbic.202200180

N/A

0DataRank · unranked

22 citations

Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu +13 more

Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase

Biochemistry(2022)10.1021/acs.biochem.2c00509

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0DataRank · unranked

14 citations

Trevor van Eeuwen, Kushol Gupta, Kenji Murakami, David W. Christianson, Jacque Faylo

Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6

Biochemistry(2022)10.1021/acs.biochem.2c00332

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0DataRank · unranked

10 citations

Ping Bai, Changning Wang, Abigail D. Cragin, Jacob M. Hooker, David W. Christianson +1 more

A Novel Zinc Binding Group for HDAC6 Inhibition

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r3604

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0DataRank · unranked

12 citations

P. R. Watson, Beate König, Finn K. Hansen, David W. Christianson, Abigail D. Cragin

Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C–N Bond-Forming Reaction of Flavunoidine Biosynthesis

Biochemistry(2022)10.1021/acs.biochem.2c00335

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0DataRank · unranked

7 citations

Danielle A. Yee, Yi Tang, David W. Christianson, Margarita A. Tararina

First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement

ChemRxiv(2022)10.26434/chemrxiv-2022-pqhtn-v4

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0DataRank · unranked

2 citations

Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu +13 more

Aza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

ChemRxiv(2022)10.26434/chemrxiv-2021-37shs-v2

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0DataRank · unranked

1 citations

Corey J. Herbst‐Gervasoni, Severin Lechner, Tracy Murray Stewart, Glynis Klinke, Johannes Ridinger +13 more

Aromatic C‐F Interactions Influence Binding Mode of Inhibitors in HDAC6

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r2257

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0DataRank · unranked

0 citations

Jacob M. Hooker, David W. Christianson, P. R. Watson

Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01345

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0DataRank · unranked

48 citations

P. R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker‐Hübner, David W. Christianson +2 more

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01385

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0DataRank · unranked

36 citations

Anja Vogelmann, F Friedrich, Margarita A. Tararina, Emilia Neuwirt, Arianna Colcerasa +19 more

Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii

Biochemistry(2023)10.1021/acs.biochem.3c00288

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0DataRank · unranked

9 citations

David W. Christianson, P. R. Watson

Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105228

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0DataRank · unranked

9 citations

Juana Goulart Stollmaier, David W. Christianson, P. R. Watson

Reprogramming the Cyclization Cascade of epi-Isozizaene Synthase to Generate Alternative Terpene Products

Biochemistry(2023)10.1021/acs.biochem.3c00247

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0DataRank · unranked

7 citations

David W. Christianson, Samuel A. Eaton

Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6

ACS Chemical Biology(2023)10.1021/acschembio.3c00113

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0DataRank · unranked

7 citations

Suchetana Gupta, Parisa Hosseinzadeh, Benjamin P. Brown, David Baker, David W. Christianson +1 more

Methods for the preparation and analysis of the diterpene cyclase fusicoccadiene synthase

Methods in enzymology on CD-ROM/Methods in enzymology(2023)10.1016/bs.mie.2023.11.003

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0DataRank · unranked

1 citations

David W. Christianson, Eliott S. Wenger

Crystal Structure of Histone Deacetylase 6 Complexed with ( R )-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.08.552419

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0DataRank · unranked

3 citations

Juana Goulart Stollmaier, David W. Christianson, P. R. Watson

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

ChemRxiv(2023)10.26434/chemrxiv-2023-6kt1w-v3

N/A

0DataRank · unranked

2 citations

P. R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker‐Hübner, David W. Christianson +2 more

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

ChemRxiv(2023)10.26434/chemrxiv-2023-6kt1w-v4

N/A

0DataRank · unranked

1 citations

P. R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker‐Hübner, David W. Christianson +2 more

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

ChemRxiv(2023)10.26434/chemrxiv-2023-6kt1w

N/A

0DataRank · unranked

0 citations

P. R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker‐Hübner, David W. Christianson +2 more

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

ChemRxiv(2023)10.26434/chemrxiv-2023-6kt1w-v2

N/A

0DataRank · unranked

0 citations

P. R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker‐Hübner, David W. Christianson +2 more

Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases

Accounts of Chemical Research(2024)10.1021/acs.accounts.3c00801

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0DataRank · unranked

30 citations

David W. Christianson

Engineering substrate channeling in a bifunctional terpene synthase

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2408064121

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0DataRank · unranked

15 citations

Kollin Schultz, Ronen Marmorstein, David W. Christianson, Eliott S. Wenger

Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation

Journal of Structural Biology(2024)10.1016/j.jsb.2023.108060

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0DataRank · unranked

5 citations

Trey A. Ronnebaum, Kollin Schultz, Jacque Faylo, Ronen Marmorstein, David W. Christianson +1 more

Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10

ACS Medicinal Chemistry Letters(2024)10.1021/acsmedchemlett.4c00293

N/A

0DataRank · unranked

4 citations

P. R. Watson, David W. Christianson, Juana Goulart Stollmaier

Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product

Biochemistry(2024)10.1021/acs.biochem.4c00476

N/A

0DataRank · unranked

3 citations

Kristin R. Osika, David W. Christianson, Matthew N. Gaynes

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi-Isozizaene Synthase into α-Bisabolol Synthase

Biochemistry(2024)10.1021/acs.biochem.3c00681

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0DataRank · unranked

3 citations

David W. Christianson, Samuel A. Eaton

Methods for the preparation and analysis of a bifunctional class II diterpene synthase, copalyl diphosphate synthase from Penicillium fellutanum

Methods in enzymology on CD-ROM/Methods in enzymology(2024)10.1016/bs.mie.2023.11.002

N/A

0DataRank · unranked

0 citations

David W. Christianson, Matthew N. Gaynes

Engineering Substrate Channeling in Assembly-Line Terpene Biosynthesis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.25.586617

N/A

0DataRank · unranked

0 citations

Kollin Schultz, Ronen Marmorstein, David W. Christianson, Eliott S. Wenger

DREDge: robust motion correction for high-density extracellular recordings across species

Nature Methods(2025)10.1038/s41592-025-02614-5

N/A

0DataRank · unranked

20 citations

Han Yu, Angelique C. Paulk, Domokos Meszéna, William Muñoz, Julien Boussard +35 more

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02373

N/A

0DataRank · unranked

13 citations

Lukas Biermann, P. R. Watson, Jingyu Li, Beate König, Matthew N. Gaynes +11 more

Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization

Nature Communications(2025)10.1038/s41467-025-60537-3

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0DataRank · unranked

4 citations

David W. Christianson, Eliott S. Wenger

Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.21.634178

N/A

0DataRank · unranked

5 citations

Minghao Li, Grace Park, Jennifer Ramirez, Hudson Lee, P. R. Watson +10 more

Crystal Structure and Catalytic Mechanism of Drimenol Synthase, a Bifunctional Terpene Cyclase-Phosphatase

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.11.637696

N/A

0DataRank · unranked

1 citations

Matthew N. Gaynes, David W. Christianson, Kristin R. Osika

Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

eLife(2025)10.7554/elife.109043

N/A

0DataRank · unranked

1 citations

Minghao Li, Grace Park, Jennifer Ramirez, Hudson Lee, P. R. Watson +10 more

Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate is Subject to Redox Modulation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.04.631333

N/A

0DataRank · unranked

0 citations

B Czarnecki, David W. Christianson, Juana Goulart Stollmaier

Structure and Mechanism of Avermitilol Synthase, a Sesquiterpene Cyclase that Generates a Highly Strained 6-6-3 Tricyclic Alcohol

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.11.675706

N/A

0DataRank · unranked

0 citations

Kristin R. Osika, David W. Christianson, Matthew N. Gaynes

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase

Biochemistry(2025)10.1021/acs.biochem.5c00509

N/A

0DataRank · unranked

0 citations

Kollin Schultz, Eliott S. Wenger, Trey A. Ronnebaum, Ronen Marmorstein, David W. Christianson +1 more

Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

eLife(2025)10.7554/elife.109043.1

N/A

0DataRank · unranked

0 citations

Minghao Li, Grace Park, Jennifer Ramirez, Hudson Lee, P. R. Watson +10 more

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.20.671325

N/A

0DataRank · unranked

1 citations

Kollin Schultz, Eliott S. Wenger, Trey A. Ronnebaum, Ronen Marmorstein, David W. Christianson +1 more

Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127023

N/A

0DataRank · unranked

55 citations

David W. Christianson, J.D. Osko