Benjamin C. Orsburn

Also affiliated with UPMC Hillman Cancer Center, Io Therapeutics (United States)

ChemistryBiochemistry, Genetics and Molecular BiologyImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 30 papers. Top paper: “Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies”.

Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies

Drug Metabolism and Disposition(2023)10.1124/dmd.122.001043

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0.558DataRank · unranked

14 citations

Colten D. Eberhard, Eric P. Mosher, Yuting Yuan, Hannah Wilkins, Herana Kamal Seneviratne +3 more

Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry

Nature Communications(2022)10.1038/s41467-022-34919-w

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74 citations

Yuting Yuan, Namandjé N. Bumpus, Benjamin C. Orsburn

EstG is a novel esterase required for cell envelope integrity in Caulobacter

Current Biology(2022)10.1016/j.cub.2022.11.037

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8 citations

Benjamin C. Orsburn, Zan Chen, Laura Álvarez, Colten D. Eberhard, Kousik Sundararajan +8 more

Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid‐Based Electrochemical Sensors

Angewandte Chemie(2022)10.1002/ange.202211292

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4 citations

Kelly Waters, Benjamin C. Orsburn, Namandjé N. Bumpus, Nandini Kundu, Jonathan T. Sczepanski +3 more

Single‐Cell Proteomic Profiling of Hepatocytes Reveals Heterogeneous Responses to Hepatotoxic Drugs Nevirapine, Efavirenz, and Acetaminophen

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r4856

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2 citations

Benjamin C. Orsburn, Namandjé N. Bumpus, Yuting Yuan

Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.12.480144

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4 citations

Yuting Yuan, Namandjé N. Bumpus, Benjamin C. Orsburn

EstG is a novel esterase required for cell envelope integrity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.12.488081

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1 citations

Benjamin C. Orsburn, Zan Chen, Laura Álvarez, Colten D. Eberhard, Kousik Sundararajan +9 more

Spatial Heterogeneity of Brain Lipids in SIV-infected Macaques Treated with Antiretroviral Therapy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.26.508302

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0 citations

Andrew M. Gausepohl, Hannah Wilkins, Colten D. Eberhard, Benjamin C. Orsburn, Dionne W. Williams +1 more

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.29.522244

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0 citations

Sanim Rahman, Benjamin C. Orsburn, Namandjé N. Bumpus, Cynthia Wolberger, Sara T. Haile

Time-of-Flight Fragmentation Spectra Generated by the Proteomic Analysis of Single Human Cells Do Not Exhibit Atypical Fragmentation Patterns

Journal of Proteome Research(2023)10.1021/acs.jproteome.2c00715

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16 citations

Benjamin C. Orsburn

Metabolomic, Proteomic, and Single-Cell Proteomic Analysis of Cancer Cells Treated with the KRAS G12D Inhibitor MRTX1133

Journal of Proteome Research(2023)10.1021/acs.jproteome.3c00212

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16 citations

Benjamin C. Orsburn

Chorioamnionitis disrupts erythropoietin and melatonin homeostasis through the placental-fetal-brain axis during critical developmental periods

Frontiers in Physiology(2023)10.3389/fphys.2023.1201699

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3 citations

Nethra K. Madurai, Sarah Hamimi, Ryan L. Hellinger, O. Angel Odukoya, Sindhu Ramachandra +11 more

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems

Drug Metabolism and Disposition(2023)10.1124/dmd.122.001195

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4 citations

Benjamin C. Orsburn, Namandjé N. Bumpus, Abigail Wheeler

Tenofovir Activation in Brain and Liver is Diminished in Creatine Kinase Brain-Type Knockout Mice

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.167260

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1 citations

Benjamin C. Orsburn, Namandjé N. Bumpus, Colten D. Eberhard

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms(2023)10.1016/j.bbagrm.2023.194929

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1 citations

Sanim Rahman, James K. Fields, Benjamin C. Orsburn, Namandjé N. Bumpus, Cynthia Wolberger +1 more

Acetic acid is a superior ion pairing modifier for sub-nanogram and single cell proteomics

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.01.551522

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4 citations

Benjamin C. Orsburn, Colten D. Eberhard

Metabolomic, proteomic and single cell proteomic analysis of cancer cells treated with the KRAS G12D inhibitor MRTX1133

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.23.533981

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2 citations

Benjamin C. Orsburn

Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.28.551042

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1 citations

Stephen Knerler, A C Price, Rodnie Colón Ortiz, Alicia Mercado, Hannah Wilkins +4 more

Identifying post-translational modifications with single cell proteomics

OSF Preprints (OSF Preprints)(2023)10.31219/osf.io/465er

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0 citations

Benjamin C. Orsburn

A multiplexed single cell proteomic workflow applicable to drug treatment studies

OSF Preprints (OSF Preprints)(2023)10.31219/osf.io/9nv5w

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0DataRank · unranked

0 citations

Benjamin C. Orsburn, Colten D. Eberhard

The Human Ganglioside Interactome in Live Cells Revealed Using Clickable Photoaffinity Ganglioside Probes

Journal of the American Chemical Society(2024)10.1021/jacs.4c03196

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0DataRank · unranked

24 citations

Mitchell J. Porter, Abduselam K. Awol, Benjamin C. Orsburn, Samuel W. Canner, Jeffrey J. Gray +4 more

Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier

Fluids and Barriers of the CNS(2024)10.1186/s12987-023-00507-3

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10 citations

Stephen Knerler, Lisa B. Fridman, Alicia Mercado, A C Price, Jose J. Rosado‐Franco +5 more

Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus

Glycobiology(2024)10.1093/glycob/cwae065

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9 citations

Anabel Gonzalez-Gil, Abduselam K. Awol, Steven J. Ackerman, Benjamin C. Orsburn, Ronald L. Schnaar +1 more

All Blood Brain Barrier Cell Types Demonstrate Capability to Influence Differential Tenofovir and Emtricitabine Metabolism and Transport in the Brain

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00510

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4 citations

Stephen Knerler, Ahmed Warshanna, Rodnie Colón Ortiz, Kate Haas, Benjamin C. Orsburn +2 more

Single cell proteomics by mass spectrometry reveals deep epigenetic insight into the actions of an orphan histone deacetylase inhibitor

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.05.574437

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13 citations

Benjamin C. Orsburn

Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.01.606165

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0DataRank · unranked

1 citations

Stephen Knerler, Ahmed Warshanna, Rodnie Colón Ortiz, Kate Haas, Benjamin C. Orsburn +2 more

Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2528478122

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5 citations

Sunil Jamuna Tripathi, Edwin Vázquez-Rosa, Kalyani Chaubey, Hisashi Fujioka, Emiko Miller +12 more

Simultaneous single-cell proteomics and epigenetic analysis of histone deacetylase inhibition in human cells

Communications Biology(2025)10.1038/s42003-025-09452-3

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3 citations

Benjamin C. Orsburn

Characterization of antipsychotic medications, amino acid signatures, and platelet-activating factor in first-episode psychosis

Biomarkers in Neuropsychiatry(2021)10.1016/j.bionps.2021.100045

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0DataRank · unranked

6 citations

Kun Yang, Ida Shinder, Benjamin C. Orsburn, Rana Rais, Shin‐ichi Kano +3 more

dELTA-MS: A Mass Spectrometry-Based Proteomics Approach for Identifying ADP-Ribosylation Sites and Forms

Journal of Proteome Research(2025)10.1021/acs.jproteome.4c00890

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0DataRank · unranked

0 citations

Emily Zahn, Richard Searfoss, Han-Byeol Kim, Morgan Dasovich, Jim Voorneveld +9 more