Ellen Sapp

Also affiliated with Massachusetts General Hospital

NeuroscienceBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 20 papers. Top paper: “Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis”.

Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis

Molecular Neurobiology(2021)10.1007/s12035-021-02557-w

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0DataRank · unranked

53 citations

Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin +19 more

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum

Frontiers in Synaptic Neuroscience(2021)10.3389/fnsyn.2021.618391

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0DataRank · unranked

22 citations

Connor Seeley, Ellen Sapp, Erin L. Jones, Callie Martin, Xueyi Li +3 more

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Nucleic Acids Research(2021)10.1093/nar/gkab1126

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20 citations

Samuel Hildebrand, Sarah M. Davis, Rachael Miller, Faith Conroy, Ellen Sapp +10 more

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.22.436505

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0DataRank · unranked

2 citations

Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin +19 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models

Nature Communications(2022)10.1038/s41467-022-33061-x

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0DataRank · unranked

49 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.29.498088

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0DataRank · unranked

0 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.06.506795

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0DataRank · unranked

0 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +13 more

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease

Molecular Therapy(2023)10.1016/j.ymthe.2023.05.006

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0DataRank · unranked

56 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +16 more

Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model

Neurobiology of Disease(2023)10.1016/j.nbd.2023.106313

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12 citations

Ellen Sapp, Adel Boudi, Sophia Liu, Connor Seeley, Deanna M. Marchionini +3 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.26.542506

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0DataRank · unranked

7 citations

Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Furguson, Ellen Sapp +18 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Research Square(2023)10.21203/rs.3.rs-2987323/v1

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4 citations

Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan Fakih +18 more

A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.19.572404

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4 citations

Qi Tang, Sam Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.26.525697

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0DataRank · unranked

1 citations

Ellen Sapp, Adel Boudi, Sophia Liu, Connor Seeley, Deanna M. Marchionini +3 more

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system

Nucleic Acids Research(2024)10.1093/nar/gkae368

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26 citations

Qi Tang, Samuel Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102359

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0DataRank · unranked

20 citations

Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato +10 more

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Nucleic Acid Therapeutics(2024)10.1089/nat.2024.0027

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0DataRank · unranked

8 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.24.590997

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0DataRank · unranked

2 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.06.597639

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0DataRank · unranked

1 citations

Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato +10 more

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation

Brain Communications(2025)10.1093/braincomms/fcaf314

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0DataRank · unranked

5 citations

Adel Boudi, Andrew Iwanowicz, Jillian Belgrad, Rachael Miller, R. Meldrum Robertson +11 more

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.24.661398

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0DataRank · unranked

7 citations

Ashley Summers, Christian Landles, Jonathan Greene, Samuel Hildebrand, Emily G. Knox +21 more