Kathleen M. Ruppel

Also affiliated with Cardiovascular Institute of the South, Equinox (United States), Stanford Medicine, Stanford University

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 19 papers. Top paper: “The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches”.

The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches

Annual Review of Biochemistry(2020)10.1146/annurev-biochem-011520-105234

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0DataRank · unranked

86 citations

Suman Nag, Annamma Spudich, Kathleen M. Ruppel, James A. Spudich, Darshan V. Trivedi

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Cell(2020)10.1016/j.cell.2020.08.050

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50 citations

Ádám I. Horváth, Demeter Túrós, Sharad Kumar Suthar, Máté Pénzes, Csilla Kurdi +13 more

Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.10.375493

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4 citations

Chao Liu, Makenna M. Morck, Kristina B. Kooiker, Gwanghyun Jung, Dan Song +12 more

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Circulation(2021)10.1161/circulationaha.121.053575

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304 citations

Kristina B. Kooiker, Mathew Ellenberger, Giovanni Fajardo, Mingming Zhao, Alison Schroer Vander Roest +18 more

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2025030118

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82 citations

Chao Liu, Makenna M. Morck, Kristina B. Kooiker, Gwanghyun Jung, Dan Song +12 more

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.11.463966

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1 citations

Debanjan Bhowmik, Aminah Dawood, James A. Spudich, Kathleen M. Ruppel, Makenna M. Morck

Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

Frontiers in Physiology(2022)10.3389/fphys.2022.975076

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56 citations

James A. Spudich, Kathleen M. Ruppel, Masataka Kawana

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

eLife(2022)10.7554/elife.76805

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24 citations

Debanjan Bhowmik, Divya Pathak, Aminah Dawood, James A. Spudich, Kathleen M. Ruppel +1 more

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Nature Communications(2023)10.1038/s41467-023-38698-w

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71 citations

Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak +6 more

Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments

Methods in molecular biology(2023)10.1007/978-1-0716-3527-8_10

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2 citations

Kathleen M. Ruppel, James A. Spudich, Chao Liu

Cryo-EM structure of the folded-back state of human β-cardiac myosin*

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.15.536999

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3 citations

Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak +6 more

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.08.544276

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2 citations

Alison Schroer Vander Roest, Cheavar A. Blair, Kerry Y. Kao, Samantha Bremner, Matthew C. Childers +19 more

Homologous mutations in β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.02.547385

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1 citations

Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J. Agostino, Gregory R. Bowman +4 more

Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy

The EMBO Journal(2024)10.1038/s44318-024-00199-x

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33 citations

Neha Nandwani, Julien Robert‐Paganin, Anne Houdusse, Kathleen M. Ruppel, James A. Spudich

Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2318413121

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14 citations

Alison S. Vander Roest, Cheavar A. Blair, Kerry Y. Kao, Samantha Bremner, Matthew C. Childers +19 more

Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2315472121

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0DataRank · unranked

5 citations

Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J. Agostino, Gregory R. Bowman +4 more

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.29.582851

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10 citations

Debanjan Bhowmik, Matthew C. Childers, Rama Reddy Goluguri, Aminah Dawood, Michael Regnier +3 more

A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.05.626936

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3 citations

Piyali Guhathakurta, Neha Nandwani, Aminah Dawood, Seiji Yakota, Osha Roopnarine +4 more

A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2504562122

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0DataRank · unranked

11 citations

Piyali Guhathakurta, Neha Nandwani, Aminah Dawood, Seiji Yokota, Osha Roopnarine +4 more