Shaun K. Olsen

The University of Texas at San Antonio Health Science Center

Also affiliated with Institute for Neurodegenerative Disorders, Cancer Research Institute of the Slovak Academy of Sciences, The University of Texas at San Antonio

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 27 papers. Top paper: “Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design”.

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Science Advances(2020)10.1126/sciadv.abd4596

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483 citations

Zongyang Lv, Mikołaj Żmudziński, Stephanie Patchett, Digant Nayak, Scott J. Snipas +6 more

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Nature Communications(2021)10.1038/s41467-021-27210-x

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0DataRank · unranked

149 citations

Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang +19 more

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Nature Communications(2021)10.1038/s41467-021-23833-2

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86 citations

Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen +3 more

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Cell Reports(2021)10.1016/j.celrep.2021.109754

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53 citations

Zongyang Lv, Wioletta Rut, Miklós Békés, Marcin Drąg, Shaun K. Olsen +2 more

Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification

Nature Communications(2021)10.1038/s41467-021-22598-y

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30 citations

Zongyang Lv, Melanie J. Adams, Shaun K. Olsen, Lingmin Yuan

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Nature Communications(2022)10.1038/s41467-022-32613-5

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17 citations

Fei Gao, Zongyang Lv, Digant Nayak, Anindita Nayak, Priscila dos Santos Bury +11 more

Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy

Cell chemical biology(2022)10.1016/j.chembiol.2022.05.011

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1 citations

Elizabeth V. Wasmuth, Shaun K. Olsen, Digant Nayak

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins – PL pro and M pro proteases, and nsp14 guanine N7- methyltransferase

Research Square(2022)10.21203/rs.3.rs-1546114/v1

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4 citations

Wioletta Rut, Kamila Olech, Jarosław M. Granda, Mirosław Giurg, Małgorzata Burda‐Grabowska +14 more

Crystal Structures of an E1‐E2‐ubiquitin Thioester Mimetic Reveal Molecular Mechanisms of Transthioesterification

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.l7463

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0 citations

Shaun K. Olsen

Structural insights into BCDX2 complex function in homologous recombination

Nature(2023)10.1038/s41586-023-06219-w

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52 citations

Lijia Jia, Aviv Meir, Shuo Zhou, Hardeep Kaur, Eliza A. Ruben +14 more

Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer

Nature Communications(2023)10.1038/s41467-023-39780-z

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30 citations

Guanqun Liu, Lijia Jia, Eliza A. Ruben, Digant Nayak, Zuberwasim Sayyad +10 more

TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells

Nucleic Acids Research(2023)10.1093/nar/gkad952

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15 citations

Arijit Dutta, Gayathri Srinivasan, Yaxia Yuan, Daohong Zhou, Montaser Shaheen +14 more

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature Communications(2024)10.1038/s41467-024-46922-4

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49 citations

Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak +8 more

Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination

Nature(2024)10.1038/s41586-024-07910-2

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35 citations

James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina +24 more

Mechanism of SETX-BRCA1-BARD1 complex in resolution of R-loops and transcription-replication conflicts

Research Square(2024)10.21203/rs.3.rs-3833044/v1

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5 citations

Arijit Dutta, Jae‐Hoon Ji, Qingming Fang, Shuo Zhou, Fengshan Liang +22 more

Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.14.618187

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0 citations

Stefanie A. Morosky, Teresa L. Rosato, Amy Henrickson, Guowu Lin, Cynthia S. Hinck +7 more

E3 ubiquitin ligases in signaling, disease, and therapeutics

Trends in Biochemical Sciences(2025)10.1016/j.tibs.2025.07.009

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33 citations

Caleb M. Stratton, Shaun K. Olsen, Pirouz Ebadi

Molecular choreography of E1 enzymes in ubiquitin-like protein cascades: New insights into dynamics and specificity

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110415

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9 citations

Pirouz Ebadi, Shaun K. Olsen, Caleb M. Stratton

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

Nature Communications(2025)10.1038/s41467-025-61283-2

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7 citations

Yashpal Rawal, Anna L Palovcak-Lightbourn, Gayatri S. Ganesan, Phoebe S. Parker, Reagan A Russell +15 more

Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation

Cell Reports(2025)10.1016/j.celrep.2025.115654

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4 citations

Wenjing Li, Mollie E. Uhrig, Jeffrey N. Katz, Shahrez Syed, Neelam Sharma +14 more

Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer

Nature Structural & Molecular Biology(2025)10.1038/s41594-025-01681-8

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4 citations

Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury +11 more

Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.168935

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1 citations

Stefanie A. Morosky, Teresa L. Rosato, Amy Henrickson, Guowu Lin, Cynthia S. Hinck +7 more

Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.28.667286

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2 citations

Surajit Chakraborty, Cindy Chiang, Caleb M. Stratton, Anna A. Tumanova, Shaun K. Olsen +2 more

Unveiling BCL-xL-specific PROTAC Efficiency and Dissociation Mechanisms Using Native Mass Spectrometry

ChemRxiv(2025)10.26434/chemrxiv-2025-zfjsj

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1 citations

Kailyn L. Nonhof, Digant Nayak, Peiyi Zhang, Olivia E. Dioli, Guangrong Zheng +4 more

Single-Assay Characterization of Ternary Complex Assembly and Activity in Targeted Protein Degradation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.20.671298

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0 citations

Vi Dougherty, Dongwen Lv, Pirouz Ebadi, Shikha Dubey, Digant Nayak +5 more

Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group

ACS Medicinal Chemistry Letters(2025)10.1021/acsmedchemlett.5c00301

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0 citations

Mikołaj Żmudziński, Mohammad Afsar, Ciyana James, Anindita Nayak, Digant Nayak +8 more

Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway

Molecular Cell(2025)10.1016/j.molcel.2025.10.028

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0 citations

Seyed Arad Moghadasi, Ankita Shukla, Farid El Oualid, Beatrix Ueberheide, Shaun K. Olsen +2 more