Gregory R. Bowman

ORCID: 0000-0002-2083-4892

Also affiliated with California University of Pennsylvania, University of Pennsylvania

Biochemistry, Genetics and Molecular BiologyComputer ScienceChemistryMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 52 papers. Top paper: “Investigating Cryptic Binding Sites by Molecular Dynamics Simulations”.

Investigating Cryptic Binding Sites by Molecular Dynamics Simulations

Accounts of Chemical Research(2020)10.1021/acs.accounts.9b00613

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215 citations

Gregory R. Bowman, Jordi Juárez‐Jiménez, Julien Michel, Francesco Luigi Gervasio, Antonija Kuzmanic

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

Cell Reports(2020)10.1016/j.celrep.2019.12.020

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53 citations

Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji‐Seung Yoo, Maxwell I. Zimmerman +7 more

Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

Science Signaling(2020)10.1126/scisignal.aay7315

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69 citations

Sjoerd van der Post, Arshag D. Mooradian, Matthew J. Egan, Maxwell I. Zimmerman, Jenna L. Clements +3 more

Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

eLife(2020)10.7554/elife.55132

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34 citations

Artur Meller, Maxwell I. Zimmerman, Michael J. Greenberg, Gregory R. Bowman, Justin R. Porter

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.17.158121

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81 citations

Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell‐Brereton, Michael D. Ward +9 more

SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.27.175430

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61 citations

Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller +13 more

SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.10.420109

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15 citations

Michael D. Ward, Maxwell I. Zimmerman, Borna Novak, Jonathan Borowsky, Sukrit Singh +2 more

DiffNets: deep learning the structural determinants of proteins biochemical properties by comparing different structural ensembles

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.01.182725

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3 citations

Maxwell I. Zimmerman, Artur Meller, Moses K. J. Chung, S. Joshua Swamidass, Gregory R. Bowman +1 more

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Nature Communications(2021)10.1038/s41467-021-21953-3

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593 citations

Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell‐Brereton, Michael D. Ward +9 more

SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome

Nature Chemistry(2021)10.1038/s41557-021-00707-0

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304 citations

Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller +13 more

SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

Biophysical Journal(2021)10.1016/j.bpj.2021.03.024

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83 citations

Michael D. Ward, Maxwell I. Zimmerman, Borna Novak, Jonathan Borowsky, Sukrit Singh +2 more

Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets

Nature Communications(2021)10.1038/s41467-021-23246-1

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80 citations

Maxwell I. Zimmerman, Artur Meller, Moses K. J. Chung, S. Joshua Swamidass, Gregory R. Bowman +1 more

Naturally Occurring Genetic Variants in the Oxytocin Receptor Alter Receptor Signaling Profiles

ACS Pharmacology & Translational Science(2021)10.1021/acsptsci.1c00095

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17 citations

Michael D. Ward, Yingye Fang, Justin R. Porter, Maxwell I. Zimmerman, Thomas Koelblen +7 more

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.14.439842

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2 citations

Upasana L. Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E. Frederick, Tairan Yuwen +4 more

Intrinsically disordered pathogen effector alters the STAT1 dimer to prevent recruitment of co-transcriptional activators CBP/p300

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.09.455663

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1 citations

Hejun Liu, Jay C. Nix, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe +2 more

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Nature Communications(2022)10.1038/s41467-022-31720-7

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39 citations

Hejun Liu, Jay C. Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman +3 more

Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102657

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17 citations

Samantha K. Barrick, Artur Meller, Jonathan Walklate, Jeffrey M. Lotthammer, Jian Wei Tay +6 more

The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102355

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7 citations

Justin J. Miller, Soumendranath Bhakat, Sumit Mukherjee, Suhas Bobba, Gregory R. Bowman +2 more

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Biophysical Journal(2022)10.1016/j.bpj.2021.11.2561

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5 citations

Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman +5 more

Multiple conserved states characterize the twist landscape of the bacterial actin homolog MreB

Computational and Structural Biotechnology Journal(2022)10.1016/j.csbj.2022.10.008

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3 citations

Michael D. Ward, Gregory R. Bowman, Handuo Shi, Kerwyn Casey Huang, Benjamin D. Knapp

Deep Generative Design of Epitope-Specific Binding Proteins by Latent Conformation Optimization

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.22.521698

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20 citations

Christian A. Choe, Udit Parekh, Irene S. Khalek, Michael D. Ward, Neha Vithani +4 more

Accelerating cryptic pocket discovery using AlphaFold

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.23.517577

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8 citations

Soumendranath Bhakat, Shahlo Solieva, Gregory R. Bowman, Artur Meller

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.02.478828

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2 citations

Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremías Incicco, Debjit Roy +7 more

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.05.506254

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1 citations

Jeffrey M. Lotthammer, Louis G. Smith, Borna Novak, Lindsey A. Lee, Catherine C Kuhn +5 more

Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network

Nature Communications(2023)10.1038/s41467-023-36699-3

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181 citations

Michael D. Ward, Jonathan Borowsky, Meghana Kshirsagar, Jeffrey M. Lotthammer, Felipe Oviedo +3 more

Accelerating Cryptic Pocket Discovery Using AlphaFold

Journal of Chemical Theory and Computation(2023)10.1021/acs.jctc.2c01189

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131 citations

Soumendranath Bhakat, Shahlo Solieva, Gregory R. Bowman, Artur Meller

Folding@home: Achievements from over 20 years of citizen science herald the exascale era

Biophysical Journal(2023)10.1016/j.bpj.2023.03.028

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69 citations

Vijay S. Pande, Gregory R. Bowman, Vincent A. Voelz

Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2215371120

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45 citations

Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremías Incicco, Debjit Roy +8 more

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

eLife(2023)10.7554/elife.83602

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35 citations

Jeffrey M. Lotthammer, Louis G. Smith, Borna Novak, Lindsey A. Lee, Catherine C Kuhn +5 more

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors

Frontiers in Molecular Biosciences(2023)10.3389/fmolb.2023.1171143

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23 citations

Saulo De Oliveira, Aram Davtyan, Tigran M. Abramyan, Gregory R. Bowman, Henry van den Bedem +1 more

Folding@home: achievements from over twenty years of citizen science herald the exascale era

arXiv (Cornell University)(2023)10.48550/arxiv.2303.08993

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4 citations

Vijay S. Pande, Gregory R. Bowman, Vincent A. Voelz

Divergent molecular phenotypes in point mutations at the same residue in beta-myosin heavy chain lead to distinct cardiomyopathies

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.03.547580

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4 citations

Artur Meller, Shahlo Solieva, Jeffrey M. Lotthammer, Lina Greenberg, Stephen J. Langer +5 more

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.22.533829

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3 citations

Saulo De Oliveira, Aram Davtyan, Tigran M. Abramyan, Gregory R. Bowman, Henry van den Bedem +1 more

Homologous mutations in β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.02.547385

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1 citations

Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J. Agostino, Gregory R. Bowman +4 more

POPSHIFT: A THERMODYNAMICALLY SOUND APPROACH TO ESTIMATE BINDING FREE ENERGIES BY ACCOUNTING FOR LIGAND-INDUCED POPULATION SHIFTS FROM A LIGAND-FREE MSM

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.14.549110

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1 citations

Borna Novak, Meghan Osato, David L. Mobley, Gregory R. Bowman, Louis G. Smith

G protein activation occurs via a largely universal mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.24.563885

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0 citations

Tyson D. Todd, Sukrit Singh, Kendall Blumer, Gregory R. Bowman, Neha Vithani

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Alzheimer s & Dementia(2024)10.1002/alz.13877

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33 citations

Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo, Xiaoying Chen +55 more

Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants

Protein Science(2024)10.1002/pro.4902

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20 citations

Devin Kelly, Louis G. Smith, Gregory R. Bowman, Artur Meller

PopShift: A Thermodynamically Sound Approach to Estimate Binding Free Energies by Accounting for Ligand-Induced Population Shifts from a Ligand-Free Markov State Model

Journal of Chemical Theory and Computation(2024)10.1021/acs.jctc.3c00870

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14 citations

Borna Novak, Meghan Osato, David L. Mobley, Gregory R. Bowman, Louis G. Smith

Accounting for Fast vs Slow Exchange in Single Molecule FRET Experiments Reveals Hidden Conformational States

Journal of Chemical Theory and Computation(2024)10.1021/acs.jctc.4c01068

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9 citations

Upasana L. Mallimadugula, Maxwell I. Zimmerman, Melissa D. Stuchell‐Brereton, Andrea Soranno, Gregory R. Bowman +1 more

Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2315472121

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5 citations

Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J. Agostino, Gregory R. Bowman +4 more

Stabilization of interdomain closure by a G protein inhibitor

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2311711121

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8 citations

Neha Vithani, Sukrit Singh, Gregory R. Bowman, Kendall Blumer, Andrea Soranno +1 more

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168892

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1 citations

Shahlo Solieva, Daniel Hwang, Viviane S. De Paula, Charina Fabilane, Michael C. Young +7 more

SGLT2 inhibitors activate pantothenate kinase in the human heart

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.07.26.605401

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13 citations

Deborah Eaton, Jiten Patel, Caitlyn E. Bowman, Ryo Kawakami, Ivan A. Kuznetsov +14 more

Rapid and accurate prediction of protein homo-oligomer symmetry with Seq2Symm

Research Square(2024)10.21203/rs.3.rs-4215086/v1

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6 citations

Artur Meller, Ian R. Humphreys, Samuel Sledzieski, Yixi Xu, Rahul Dodhia +7 more

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.04.616739

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5 citations

Shahlo Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh +34 more

The G protein inhibitor YM-254890 is an allosteric glue

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.11.25.625299

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5 citations

Justin J. Miller, Gregory R. Bowman, Tony Trent

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.22.609218

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1 citations

Matthew A. Cruz, Neha Vithani, Maxwell I. Zimmerman, Gregory R. Bowman, Upasana L. Mallimadugula

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

eLife(2025)10.7554/elife.104514.3

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3 citations

Matthew A. Cruz, Neha Vithani, Maxwell I. Zimmerman, Gregory R. Bowman, Upasana L. Mallimadugula

The G Protein Inhibitor YM-254890 is an Allosteric Glue

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169084

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5 citations

Justin J. Miller, Kendall Blumer, Gregory R. Bowman, Tony Trent

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

eLife(2025)10.7554/elife.104514

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1 citations

Matthew A. Cruz, Neha Vithani, Maxwell I. Zimmerman, Gregory R. Bowman, Upasana L. Mallimadugula

Pathogenic BRCA1 mutations disrupt allosteric control by BARD1

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.07.658438

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0 citations

Gregory R. Bowman, Ayan Bhattacharjee