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Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

eLife(2025)10.7554/elife.104514Source: DataRank Database

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes is a research paper published in eLife (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (4 grants)OA: goldTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Matthew A. Cruz ORCID,Neha Vithani ORCID,Maxwell I. Zimmerman ORCID,Gregory R. Bowman ORCID,Upasana L. Mallimadugula ORCID

Live enrichment

PubMed:40892042 PMC:PMC12404614 OpenAlex:https://openalex.org/W4406048375

National Institute of General Medical Sciences

Grant: R35GM152085

NSF Division of Molecular and Cellular Biosciences

Grant: 2218156

National Institutes of Health

Grant: F31AI157079

NIGMS NIH HHS

Grant: R25 GM103757

goldLicense: cc-by

journalhttps://elifesciences.org/reviewed-preprints/104514.pdf

publisherhttps://elifesciences.org/reviewed-preprints/104514.pdf

publisherhttps://cdn.elifesciences.org/articles/104514/elife-104514-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/104514/elife-104514-v1.xml

publisherhttps://elifesciences.org/articles/104514

Fields of Study

RNA and protein synthesis mechanismsRNA Research and SplicingRNA regulation and diseaseRNA, Double-StrandedViral Regulatory and Accessory ProteinsProtein BindingEbolavirusModels, MolecularMarburgvirusProtein ConformationBinding SitesRNA-Binding Proteins

MeSH Terms

Binding SitesModels, MolecularProtein BindingProtein ConformationRNA, Double-StrandedRNA-Binding ProteinsMarburgvirusEbolavirusViral Regulatory and Accessory Proteins

Keywords

Closing (real estate)RNAComputational biologyVirologyGeneticsBiologyCell biologyBusinessBiochemistryprotein dynamicsStructural BiologyAllosteryNoneChemical BiologyMolecular BiophysicsCryptic Pocket

Sustainable Development Goals

SDG 0: Good health and well-being

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

FAIR Checklist

Authors (5)

Funding (4 grants)

Open Access

Topics

Annotations (Europe PMC)