Thomas J. Gardella

Also affiliated with Endocrine Society, Massachusetts General Hospital

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 22 papers. Top paper: “Improved GPCR ligands from nanobody tethering”.

Improved GPCR ligands from nanobody tethering

Nature Communications(2020)10.1038/s41467-020-15884-8

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0DataRank · unranked

68 citations

Fabian A. Fischer, Andrew W. Woodham, Eileen J. Daley, Naomi Suminski, Thomas J. Gardella +2 more

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH

JBMR Plus(2020)10.1002/jbm4.10441

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31 citations

Shiv Kumar Verma, Ashok Khatri, Thomas Dean, Olga Göransson, Thomas J. Gardella +2 more

Optimization of PTH / PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog ( LA‐PTH )

JBMR Plus(2020)10.1002/jbm4.10367

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28 citations

Makoto Okazaki, Eri Joyashiki, Tatsuya Tamura, Yoshiki Kawabe, Ashok Khatri +5 more

Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues

Endocrinology(2020)10.1210/endocr/bqaa216

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7 citations

Ashok Khatri, Thomas Dean, Jean‐Pierre Vilardaga, Saheem A. Zaidi, Vsevolod Katritch +2 more

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Science Signaling(2021)10.1126/scisignal.abc5944

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0DataRank · unranked

83 citations

Karina A. Peña, Lisa J. Clark, Christian Santa Maria, Shi Liu, Frédéric Jean‐Alphonse +14 more

Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands

RSC Chemical Biology(2021)10.1039/d1cb00118c

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20 citations

Fabian A. Fischer, Thomas J. Gardella, Hidde L. Ploegh, Ross W. Cheloha

Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling

Cell chemical biology(2021)10.1016/j.chembiol.2021.05.020

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15 citations

Ross W. Cheloha, Tomoyuki Watanabe, Thomas J. Gardella, Jeremy M. Baskin, Dongjun Liang

Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102332

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18 citations

Alex D. White, Sofya Savransky, Ignacio Portales Castillo, Frédéric Jean‐Alphonse, Thomas J. Gardella +3 more

Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay

ACS Chemical Biology(2022)10.1021/acschembio.2c00595

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13 citations

Brian P. Cary, Tae Wook Kim, Kevin D. Nguyen, Thomas J. Gardella, Samuel H. Gellman +1 more

Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice

Endocrinology(2022)10.1210/endocr/bqac054

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12 citations

Sung-Hee Yoon, Monica Reyes, Michael Bruce, Daniel J. Brooks, Mary Bouxsein +7 more

Functional Properties of Two Distinct PTH1R Mutants Associated With Either Skeletal Defects or Pseudohypoparathyroidism

JBMR Plus(2022)10.1002/jbm4.10604

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6 citations

Thomas Dean, Ashok Khatri, Harald Jüppner, Thomas J. Gardella, Ignacio Portales‐Castillo

Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome

Communications Biology(2023)10.1038/s42003-023-04966-0

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14 citations

Thomas Dean, Ross W. Cheloha, Brendan A. Creemer, Jean‐Pierre Vilardaga, Sofya Savransky +4 more

Substantially Delayed Maturation of Growth Plate Chondrocytes in “Humanized” PTH1R Mice with the H223R Mutation of Jansen's Disease

JBMR Plus(2023)10.1002/jbm4.10802

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11 citations

Damla Firat, Patrick Hanna, Mohd Golam Quader Khan, Michael Bruce, Maria Shvedova +5 more

Homozygous Ser-1 to Pro-1 mutation in parathyroid hormone identified in hypocalcemic patients results in secretion of a biologically inactive pro-hormone

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2208047120

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6 citations

Ashok Khatri, Shawn Choi, Séverine Brabant, Matti L. Gild, Marie Piketty +8 more

Highly biased agonism for GPCR ligands via nanobody tethering

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.10.561766

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0DataRank · unranked

0 citations

Brendan A. Creemer, Thomas J. Gardella, Ross W. Cheloha, Shivani Sachdev

Highly biased agonism for GPCR ligands via nanobody tethering

Nature Communications(2024)10.1038/s41467-024-49068-5

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26 citations

Brendan A. Creemer, Thomas J. Gardella, Ross W. Cheloha, Shivani Sachdev

Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis

Journal of Bone and Mineral Research(2024)10.1093/jbmr/zjae148

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4 citations

Jeremy Allgrove, Jakob Höppner, Moira Cheung, Saji Alexander, Lorenzo Garagnani +5 more

Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants

Journal of the American Chemical Society(2024)10.1021/jacs.3c09694

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5 citations

Eileen J. Daley, Lauren My-Linh Tran, Zhen Yu, Monica Reyes, Thomas Dean +8 more

Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.28.601153

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1 citations

Tadatoshi Sato, Caroline Houghton, Parthena E. Kotsalidis, Katelyn E. Strauss, Thomas Dean +5 more

A mouse model of Jansen’s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2500176122

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6 citations

Damla Firat, Mohd Parvez-Khan, Monica Reyes, Patrick Hanna, Prem Swaroop Yadav +12 more

Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation

Nature Communications(2025)10.1038/s41467-025-59665-7

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6 citations

H Noda, Anju Krishnan Anitha, Ross W. Cheloha, Thomas Dean, Michael I. Bruce +8 more

A novel brachydactyly type E syndrome caused by variants in helix 8 of the PTH1R

Journal of Bone and Mineral Research(2025)10.1093/jbmr/zjaf134

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1 citations

Jakob Höppner, H. Jüppner, Audrey Rick, Elyshia McNamara, William Tee +9 more