Robert T. Dirksen

Also affiliated with University of Rochester

Biochemistry, Genetics and Molecular BiologyMedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 36 papers. Top paper: “Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility”.

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility

Nature Communications(2022)10.1038/s41467-022-31088-8

N/A

0.793DataRank · unranked

17 citations

Linda Groom, Alper Celik, Natalia Kraeva, Chang Seok Lee, Sung Yun Jung +8 more

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Nature Communications(2020)10.1038/s41467-020-18865-z

N/A

0.489DataRank · unranked

25 citations

Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle W. Babcock +18 more

Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

Nature Aging(2025)10.1038/s43587-025-00902-5

N/A

0.425DataRank · unranked

16 citations

Nidhi Shah, Sarah Hachmer, Noah Salama, Fanju W. Meng, Alireza Mousaei +12 more

Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice

The Journal of General Physiology(2022)10.1085/jgp.202213114

N/A

0.396DataRank · unranked

13 citations

Laura Pietrangelo, Giorgia Rastelli, Feliciano Protasi, Robert T. Dirksen, Simona Boncompagni +1 more

An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease

The EMBO Journal(2024)10.1038/s44318-024-00273-4

N/A

0.292DataRank · unranked

6 citations

Antonio Michelucci, Laura Pietrangelo, Sundeep Malik, Linda Groom, Jennifer Leigh +8 more

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.29.559036

N/A

0.208DataRank · unranked

3 citations

Nan Zhao, Haley M. Orciuoli, Alice Brasile, Laura Pietrangelo, Miao He +8 more

NAD+ dyshomeostasis in RYR1-related myopathies

Skeletal Muscle(2025)10.1186/s13395-025-00390-6

N/A

0.165DataRank · unranked

2 citations

Willa Riekhof, Linda Groom, Pooja Varma, Irene C. Chrismer, Angela Kokkinis +12 more

Variant Curation Expert Panel Recommendations for RYR1 Pathogenicity Assertions in Malignant Hyperthermia Susceptibility

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.29.402768

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0DataRank · unranked

3 citations

Robert T. Dirksen, Thierry Girard, Stephen G. Gonsalves, Philip M. Hopkins, Sheila Riazi +8 more

Calmodulin Binding to the 3614–3643 Region of RyR1 Is Not Essential for Excitation–Contraction Coupling in Skeletal Myotubes

UNC Libraries(2020)10.17615/9zqp-r885

N/A

0DataRank · unranked

0 citations

Kristen O'Connell, Gerhard Meissner, Naohiro Yamaguchi, Robert T. Dirksen

Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility

Genetics in Medicine(2021)10.1038/s41436-021-01125-w

N/A

0DataRank · unranked

84 citations

Robert T. Dirksen, Thierry Girard, Stephen G. Gonsalves, Philip M. Hopkins, Sheila Riazi +8 more

Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

Metabolites(2021)10.3390/metabo11070424

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0DataRank · unranked

68 citations

Liang Chen, Feliciano Protasi, Robert T. Dirksen, Antonio Michelucci

Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers

The Journal of General Physiology(2021)10.1085/jgp.202112976

N/A

0DataRank · unranked

5 citations

Linda Groom, Robert T. Dirksen, Lan Wei‐LaPierre

How mutations in RYR1 that cause malignant hyperthermia increase RYR1 sensitivity to activators

Cell Calcium(2021)10.1016/j.ceca.2021.102412

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0DataRank · unranked

0 citations

Robert T. Dirksen, Susan L. Hamilton, Matthew L. Baker

A novel zebrafish model of SPEG -related centronuclear myopathy (CNM): characterization and comparison with other CNM model zebrafish

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.22.473918

N/A

0DataRank · unranked

0 citations

Salma Geissah, Linda Groom, Jonathan Volaptti, Ian C. Scott, Robert T. Dirksen +3 more

Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer’s Disease

Antioxidants(2022)10.3390/antiox11040692

N/A

0DataRank · unranked

83 citations

Robert T. Dirksen, Andrew P. Wojtovich, John O. Onukwufor

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

The Journal of General Physiology(2022)10.1085/jgp.202213081

N/A

0DataRank · unranked

19 citations

Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen, Maricela García‐Castañeda

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis

Frontiers in Immunology(2022)10.3389/fimmu.2022.1026574

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0DataRank · unranked

8 citations

Javier Rangel‐Moreno, Maricela Garcia-Castaneda, H. Mark Kenney, Ananta Paine, Michael Thullen +5 more

Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress

Skeletal Muscle(2022)10.1186/s13395-022-00291-y

N/A

0DataRank · unranked

10 citations

Jacob G. Kallenbach, Haley M. Orciuoli, Nicole D. Paris, John F. Bachman, Carl J. Johnston +5 more

Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy

Disease Models & Mechanisms(2022)10.1242/dmm.049437

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0DataRank · unranked

9 citations

Salma Geissah, Linda Groom, Jonathan Volpatti, Ian C. Scott, Robert T. Dirksen +3 more

Updated Variant Curation Expert Panel Criteria and Pathogenicity Classifications for 251 Variants for RYR1 -related Malignant Hyperthermia Susceptibility

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.23.497341

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0DataRank · unranked

1 citations

Robert T. Dirksen, Thierry Girard, Philip M. Hopkins, Natalia Kraeva, Ognoon Mungunsukh +13 more

Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy

Human Molecular Genetics(2023)10.1093/hmg/ddad178

N/A

0DataRank · unranked

3 citations

Linda Groom, Sabrina M. Wang, Emanuela Pannia, Nigel Griffiths, Jenica L.M. Van Gennip +5 more

Glutathione supports lipid abundance in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.10.524960

N/A

0DataRank · unranked

3 citations

Emily Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh +33 more

Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

Nature Communications(2024)10.1038/s41467-024-50454-2

N/A

0DataRank · unranked

54 citations

Emily Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh +33 more

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity

Free Radical Biology and Medicine(2024)10.1016/j.freeradbiomed.2024.09.034

N/A

0DataRank · unranked

9 citations

Kaitlin B Chung, B. Paige Lawrence, M. Kerry O’Banion, Robert T. Dirksen, Andrew P. Wojtovich +2 more

Constitutive, Muscle-Specific Orai1 Knockout Results in the Incomplete Assembly of Ca2+ Entry Units and a Reduction in the Age-Dependent Formation of Tubular Aggregates

Biomedicines(2024)10.3390/biomedicines12081651

N/A

0DataRank · unranked

5 citations

Matteo Serano, Miao He, Jennifer Leigh, Giorgia Rastelli, Robert T. Dirksen +3 more

Individuals and Families Affected by RYR1-Related Diseases: The Patient/Caregiver Perspective

Journal of Neuromuscular Diseases(2024)10.3233/jnd-240029

N/A

0DataRank · unranked

3 citations

Lizan Stinissen, Andrew Huseth, Brentney Simon, Jennifer Ryan, Anna Sárközy +8 more

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.08.607074

N/A

0DataRank · unranked

1 citations

Kaitlin B Chung, B. Paige Lawrence, M. Kerry O’Banion, Robert T. Dirksen, Andrew P. Wojtovich +2 more

Evaluation of dynamin 2 knockdown as a therapeutic strategy for RYR1 related myopathy

Neuromuscular Disorders(2025)10.1016/j.nmd.2025.105339

N/A

0DataRank · unranked

1 citations

Linda Groom, Liang Chen, Belinda S. Cowling, Mohammad M Ghahramani-Seno, Robert T. Dirksen +2 more

Muscle-specific SMN reduction reveals motor neuron–independent disease in spinal muscular atrophy models

Journal of Clinical Investigation(2020)10.1172/jci131989

N/A

0DataRank · unranked

100 citations

Narendra Nath Jha, Zhihua Feng, Michelle R. Faleiro, Claudia A. Chiriboga, Lan Wei‐LaPierre +4 more

Calibrating a functional assay for variant classification in RYR1 -related malignant hyperthermia susceptibility

Human Molecular Genetics(2025)10.1093/hmg/ddaf038

N/A

0DataRank · unranked

0 citations

Amber Douglass, Marwan A. Hawari, Linda Groom, Kathryn M. Stowell, Robert T. Dirksen +3 more

Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature

Skeletal Muscle(2020)10.1186/s13395-020-00243-4

N/A

0DataRank · unranked

93 citations

Joshua J. Todd, Jessica W. Witherspoon, Carsten G. Bönnemann, James J. Dowling, Susan L. Hamilton +3 more

Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA

The Journal of General Physiology(2020)10.1085/jgp.201912450

N/A

0DataRank · unranked

13 citations

David S. Auerbach, Zhen Zhi Tang, Charles A. Thornton, Robert T. Dirksen, Kevin M. Tylock

Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice

The Journal of General Physiology(2020)10.1085/jgp.202012617

N/A

0DataRank · unranked

46 citations

Simona Boncompagni, Laura Pietrangelo, Takahiro Takano, Feliciano Protasi, Robert T. Dirksen +1 more

Genomic Screening for Malignant Hyperthermia Susceptibility

Anesthesiology(2020)10.1097/aln.0000000000003547

N/A

0DataRank · unranked

40 citations

Robert T. Dirksen, Thierry Girard, Philip M. Hopkins, Sheila Riazi, Henry Rosenberg +3 more

Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene

UNC Libraries(2020)10.17615/hrbk-2487

N/A

0DataRank · unranked

4 citations

Michael Rose, Farshid Ghassemi, Susan Treves, Stefan Buk, Caroline A. Sewry +15 more

Muscle weakness in Ryr1 I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca 2+ ion permeation and release from the sarcoplasmic reticulum

UNC Libraries(2020)10.17615/c8af-7374

N/A

0DataRank · unranked

2 citations

Robert T. Dirksen, David H. MacLennan, Gerhard Meissner, Murat Orynbayev, W. Melzer +5 more