🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Ashley Hutchinson

University Health Network

ORCID: 0000-0002-3481-8025

Also affiliated with Health Net

Biochemistry, Genetics and Molecular BiologyMedicineNeuroscienceComputer Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile
0Author DataRank

Indexed papers

1in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Top data-sharing exemplar

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A resource to enable chemical biology and drug discovery of WDR Proteins

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.03.583197
Top 100%
0DataRank
Top 100%0 citations

Fengling Li, Magda Szewczyk, Almagul Seitova, P. Loppnau, Hong Zeng +65 more

Papers

Driven by 21 papers — median percentile 0. Top paper: “CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13”.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

Journal of Chemical Information and Modeling(2025)10.1021/acs.jcim.5c00535
N/A
0.292DataRank · unranked
6 citations

Madhushika Silva, Ayaz Ahmad, Oscar E. A. Arce, Roly J. Armstrong, Cheryl Arrowsmith +105 more

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

ChemRxiv(2025)10.26434/chemrxiv-2025-8f0rq-v3
N/A
0.165DataRank · unranked
2 citations

Madhushika Silva, Abd Al‐Aziz A. Abu‐Saleh, Ayaz Ahmad, Jesus Antonio Alvarado-Huayhuaz, Oscar E. A. Arce +104 more

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

ChemRxiv(2025)10.26434/chemrxiv-2025-8f0rq
N/A
0.150DataRank · unranked
1 citations

Madhushika Silva, Abd Al‐Aziz A. Abu‐Saleh, Ayaz Ahmad, Jesus Antonio Alvarado-Huayhuaz, Oscar E. A. Arce +104 more

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

Communications Biology(2021)10.1038/s42003-021-02895-4
N/A
0DataRank · unranked
59 citations

Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle +15 more

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.23.449282
N/A
0DataRank · unranked
22 citations

Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li +9 more

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.02.438217
N/A
0DataRank · unranked
3 citations

Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle +12 more

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

Nature Chemical Biology(2022)10.1038/s41589-022-01059-7
N/A
0DataRank · unranked
211 citations

Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li +9 more

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.21.516512
N/A
0DataRank · unranked
1 citations

Justin C. Deme, Claudia Alvarez, P. Loppnau, Ashley Hutchinson, Alma Seitova +9 more

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01471
N/A
0DataRank · unranked
18 citations

Jin Xu, Jianwen A. Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi +20 more

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40

Structure(2023)10.1016/j.str.2023.06.002
N/A
0DataRank · unranked
16 citations

Justin C. Deme, Claudia Alvarez, P. Loppnau, Ashley Hutchinson, Alma Seitova +9 more

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.21.552681
N/A
0DataRank · unranked
2 citations

Jin Xu, Jianwen A. Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi +19 more

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c02010
N/A
0DataRank · unranked
22 citations

Fengling Li, Magda Szewczyk, Almagul Seitova, P. Loppnau, Hong Zeng +67 more

Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c01795
N/A
0DataRank · unranked
13 citations

Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B. Miller +15 more

Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials”

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01411
N/A
0DataRank · unranked
1 citations

Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B. Miller +15 more

A resource to enable chemical biology and drug discovery of WDR Proteins

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.03.583197
Top 100%
0DataRank
Top 100%0 citations

Fengling Li, Magda Szewczyk, Almagul Seitova, P. Loppnau, Hong Zeng +65 more

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1

Chemical Science(2025)10.1039/d4sc07532c
N/A
0DataRank · unranked
5 citations

Marta Glavatskikh, Xiaowen Wang, Antonio Jesús Lara Ordóñez, Fengling Li, Irene Chau +17 more

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities

Journal of Chemical Information and Modeling(2025)10.1021/acs.jcim.5c00588
N/A
0DataRank · unranked
1 citations

Evgeny Gutkin, Francesco Gentile, Fuqiang Ban, S. Benjamin Koby, Fengling Li +19 more

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.05.674529
N/A
0DataRank · unranked
2 citations

Rahul Ravichandran, G.J. Correy, Oleksandra Herasymenko, Madhushika Silva, Suzanne Ackloo +11 more

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1

UNC Libraries(2025)10.17615/qcft-3792
N/A
0DataRank · unranked
0 citations

Suzanne Ackloo, C. Arrowsmith, Alma Seitova, Li F, Albina Bolotokova +17 more

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2

ChemRxiv(2025)10.26434/chemrxiv-2025-d1v7v
N/A
0DataRank · unranked
0 citations

Madhushika Silva, G.J. Correy, Abd Al‐Aziz A. Abu‐Saleh, Suzanne Ackloo, C. Arrowsmith +74 more

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

UNC Libraries(2025)10.17615/d4ft-pp53
N/A
0DataRank · unranked
0 citations

John W. Cuozzo, Peter J. Brown, Jianwen A. Feng, Pegah Ghiabi, Ashley Hutchinson +20 more