Alyssa N. Coyne

MedicineBiochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

3.5Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Nature Neuroscience(2022)10.1038/s41593-021-01006-0

Top 7%

3.1DataRank

Top 7%159 citations

Terri G. Thompson, Jonathan Li, Julia Kaye, Ryan G. Lim, Jie Wu +95 more

Papers

Driven by 27 papers — median percentile 75. Top paper: “Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines”.

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Nature Neuroscience(2022)10.1038/s41593-021-01006-0

Top 7%

3.1DataRank

Top 7%159 citations

Terri G. Thompson, Jonathan Li, Julia Kaye, Ryan G. Lim, Jie Wu +95 more

Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

Nature Computational Science(2022)10.1038/s43588-022-00299-w

N/A

1.8DataRank · unranked

54 citations

Kristen Severson, Soumya Ghosh, Karen Sachs, Answer ALS, Emily G. Baxi +94 more

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

iScience(2021)10.1016/j.isci.2021.103221

N/A

0.593DataRank · unranked

51 citations

Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono +92 more

NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency

Scientific Data(2023)10.1038/s41597-022-01687-7

Top 44%

0.427DataRank

Top 44%11 citations

Vineet Vaibhav, Ronald J. Holewinski, Vidya Venkatraman, Victoria Dardov, Danica-Mae Manalo +32 more

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

Science Translational Medicine(2021)10.1126/scitranslmed.abd5991

N/A

0DataRank · unranked

80 citations

Haruo Aikawa, Rita Fuerst, Yue Li, Andrei Ursu, Samantha M. Meyer +19 more

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

Cell Reports(2021)10.1016/j.celrep.2021.108925

N/A

0DataRank · unranked

32 citations

Zhe Zhang, Kirstin Maulding, Alyssa N. Coyne, Weiwei Cheng, Lindsey R. Hayes +4 more

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01228-0

N/A

0DataRank · unranked

23 citations

Jeffrey D. Rothstein, Alyssa N. Coyne

Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01150-5

N/A

0DataRank · unranked

13 citations

Jeffrey D. Rothstein, Alyssa N. Coyne

Nuclear pore complexes — a doorway to neural injury in neurodegeneration

Nature Reviews Neurology(2022)10.1038/s41582-022-00653-6

N/A

0DataRank · unranked

96 citations

Jeffrey D. Rothstein, Alyssa N. Coyne

Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins

Science Translational Medicine(2022)10.1126/scitranslmed.abq3215

N/A

0DataRank · unranked

23 citations

Quinlan T. Mewborne, Amandeep Girdhar, Udit Sheth, Alyssa N. Coyne, Ritika Punathil +23 more

SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis

Brain(2023)10.1093/brain/awad291

N/A

0DataRank · unranked

40 citations

Sampath Rapuri, Emma Mehlhop, Alyssa N. Coyne, Victoria Baskerville

G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons

Acta Neuropathologica(2023)10.1007/s00401-023-02652-3

N/A

0DataRank · unranked

38 citations

Victoria Baskerville, Sampath Rapuri, Emma Mehlhop, Paymaan Jafar‐Nejad, Frank Rigo +5 more

Nuclear pore complex and nucleocytoplasmic transport disruption in neurodegeneration

FEBS Letters(2023)10.1002/1873-3468.14729

N/A

0DataRank · unranked

25 citations

Sampath Rapuri, Alyssa N. Coyne, América Chandía Cristi

Highly variable molecular signatures of TDP-43 loss of function are associated with nuclear pore complex injury in a population study of sporadic ALS patient iPSNs

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.12.571299

N/A

0DataRank · unranked

17 citations

Caroline Warlick, Alyssa N. Coyne, Jeffrey D. Rothstein

G 2 C 4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in C9orf72 ALS/FTD human neurons

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.26.546581

N/A

0DataRank · unranked

0 citations

Victoria Baskerville, Sampath Rapuri, Emma Mehlhop, Paymaan Jafar‐Nejad, Frank Rigo +5 more

Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls

Nature Communications(2024)10.1038/s41467-024-47758-8

N/A

0DataRank · unranked

13 citations

Kelsey Valentine, Velina Kozareva, Aneesh Donde, Aaron P. Frank, Susan Lei +95 more

Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease

Nucleus(2024)10.1080/19491034.2024.2349085

N/A

0DataRank · unranked

14 citations

Alyssa N. Coyne, Olivia Keeley

CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS

Acta Neuropathologica Communications(2024)10.1186/s40478-024-01916-7

N/A

0DataRank · unranked

10 citations

Emma Mendoza, Druv Menon, Alyssa N. Coyne, Olivia Keeley

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes

Neuron(2024)10.1016/j.neuron.2024.10.007

N/A

0DataRank · unranked

7 citations

Jenny H To, Vaishali Gautam, Lena Annika Street, Chloe Nguyen, Jack T. Naritomi +19 more

Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Nature Neuroscience(2025)10.1038/s41593-025-01889-3

N/A

0DataRank · unranked

32 citations

Alexander J. Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé +18 more

Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function

Nature Communications(2025)10.1038/s41467-025-62482-7

N/A

0DataRank · unranked

14 citations

Olivia Keeley, Caroline Warlick, Timothy M. Miller, Cindy V. Ly, Jonathan D. Glass +2 more

Visualizing nuclear pore complex plasticity with pan-expansion microscopy

The Journal of Cell Biology(2025)10.1083/jcb.202409120

N/A

0DataRank · unranked

11 citations

Emma Carley, Alyssa N. Coyne, Jeffrey D. Rothstein, C. Patrick Lusk, Megan C. King +1 more

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

Neuron(2020)10.1016/j.neuron.2020.06.027

N/A

0DataRank · unranked

169 citations

Benjamin L. Zaepfel, Lindsey R. Hayes, Boris Fitchman, Yuval Salzberg, En‐Ching Luo +10 more

Identification of molecular and clinical ALS subgroups based on TDP-43 loss of function molecular markers from population-based patient-derived iPS motor neurons

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.28.696512

N/A

0DataRank · unranked

1 citations

shaili tripathi, Yike Guo, Parimala Vedula, R. Li, Michael Potanin +9 more

G 4 C 2 repeat RNA mediates the disassembly of the nuclear pore complex in C9orf72 ALS/FTD

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.13.947721

N/A

0DataRank · unranked

3 citations

Benjamin L. Zaepfel, Lindsey R. Hayes, Boris Fitchman, Yuval Salzberg, Kelly Bowen +7 more

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.01.362269

N/A

0DataRank · unranked

3 citations

Emilda Gomez, Lindsay Panther, Aaron P. Frank, Susan Lei, Berhan Mandefro +40 more

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Science Translational Medicine(2021)10.1126/scitranslmed.abe1923

N/A

0DataRank · unranked

148 citations

Victoria Baskerville, Benjamin L. Zaepfel, Dennis W. Dickson, Frank Rigo, Frank Bennett +3 more

Alyssa N. Coyne

Indexed papers

Top data-sharing exemplar

Papers