🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

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Andrew D. Huber

Andrew D. Huber

St. Jude Children's Research Hospital

ORCID: 0000-0002-3790-8368

Pharmacology, Toxicology and PharmaceuticsMedicineImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 16 papers. Top paper: “A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR”.

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research(2023)10.1093/nar/gkad1175

N/A

0.352DataRank · unranked

7 citations

Shyaron Poudel, Jing Wu, Darcie J. Miller, Wenwei Lin, Lei Yang +7 more

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Drug Metabolism and Disposition(2022)10.1124/dmd.122.000858

N/A

0DataRank · unranked

39 citations

Andrew D. Huber, Taosheng Chen, Shyaron Poudel

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Nucleic Acids Research(2022)10.1093/nar/gkac133

N/A

0DataRank · unranked

38 citations

Efren Garcia-Maldonado, Sergio C. Chai, Boer Xie, Shirish Chodankar, Andrew D. Huber +10 more

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217804120

N/A

0DataRank · unranked

18 citations

Andrew D. Huber, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure(2023)10.1016/j.str.2023.08.020

N/A

0DataRank · unranked

14 citations

Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J. Miller +2 more

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

Genes & Diseases(2023)10.1016/j.gendis.2023.101079

N/A

0DataRank · unranked

6 citations

Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D. Huber +6 more

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Acta Pharmaceutica Sinica B(2023)10.1016/j.apsb.2023.07.014

N/A

0DataRank · unranked

11 citations

Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett‐Miller +2 more

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Viruses(2023)10.3390/v15040981

N/A

0DataRank · unranked

2 citations

Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice +4 more

Structure-guided approach to modulate small molecule binding to the promiscuous pregnane X receptor

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.524030

N/A

0DataRank · unranked

0 citations

Wenwei Lin, Shyaron Poudel, Yongtao Li, J. Seetharaman, Darcie J. Miller +2 more

Regulation of PXR in drug metabolism: chemical and structural perspectives

Expert Opinion on Drug Metabolism & Toxicology(2024)10.1080/17425255.2024.2309212

N/A

0DataRank · unranked

26 citations

Andrew D. Huber, Taosheng Chen, Rebecca R. Florke Gee

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Nature Communications(2024)10.1038/s41467-024-48472-1

N/A

0DataRank · unranked

20 citations

Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu +5 more

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network

Structure(2024)10.1016/j.str.2024.09.016

N/A

0DataRank · unranked

10 citations

Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chen, Andrew D. Huber

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01926

N/A

0DataRank · unranked

10 citations

Kwan‐Young Jung, Yongtao Li, Wenwei Lin, Jing Wu, Shyaron Poudel +5 more

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators

Structure(2025)10.1016/j.str.2025.09.011

N/A

0DataRank · unranked

2 citations

Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu, Darcie J. Miller +2 more

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b02067

N/A

0DataRank · unranked

59 citations

Jude Chenge, Jingheng Wang, Hazel M. Girvan, Lei Yang, Sergio C. Chai +6 more

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

Nature Communications(2025)10.1038/s41467-025-64773-5

N/A

0DataRank · unranked

1 citations

Wenwei Lin, Kwan‐Young Jung, Shyaron Poudel, Guangwei Yang, Jing Wu +15 more