Lei Shi

EngineeringBiochemistry, Genetics and Molecular BiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 62 papers. Top paper: “GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision”.

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Cell(2022)10.1016/j.cell.2022.03.042

N/A

0.708DataRank · unranked

111 citations

Daniel S. Terry, G. Glenn Gregorio, Alem W. Kahsai, Alessandro Borgia, Bing Xie +13 more

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Cell Reports(2021)10.1016/j.celrep.2021.109040

N/A

0.515DataRank · unranked

30 citations

Kathleen A. Trychta, Shyh‐Ming Yang, Susanne Bäck, Adam Yasgar, Emily S. Wires +21 more

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.1c00856

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0.483DataRank · unranked

24 citations

Andrew D. Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Mary Kudaibergenova +9 more

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

Communications Biology(2022)10.1038/s42003-022-03191-5

N/A

0.434DataRank · unranked

17 citations

Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler +7 more

Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.3c00322

N/A

0.269DataRank · unranked

5 citations

Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela Andrea Camacho‐Hernandez, Amarachi V. Okorom +7 more

Bayesian Confidence Interval for the Ratio of Marginal Probabilities in the Matched-Pair Design

Communications in Statistics - Theory and Methods(2009)10.1080/03610920802404116

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0.165DataRank · unranked

2 citations

Peng Bai, Lei Shi

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00424

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0DataRank · unranked

25 citations

R. Benjamin Free, Warren S. Weiner, Emmanuel Akano, Disha M. Gandhi, Ara M. Abramyan +10 more

Functional impact of cancer patient‐associated Bcl‐xL mutations

MedComm(2020)10.1002/mco2.36

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0DataRank · unranked

7 citations

Joseph Na, Samantha Li, Zhengming Chen, George Zhang, Sharon Pang +5 more

Collagen peptide simulated bending after applied axial deformation

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials(2020)10.1016/j.jmbbm.2020.103835

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0DataRank · unranked

3 citations

Lei Shi, Peter A. Torzilli, Jonathan W. Bourne

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

Molecular Pharmacology(2021)10.1124/molpharm.121.000336

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0DataRank · unranked

40 citations

Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K. A. Willette +8 more

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Biomolecules(2021)10.3390/biom11040570

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0DataRank · unranked

23 citations

Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy Hauck Newman +3 more

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

eLife(2021)10.7554/elife.68039

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0DataRank · unranked

23 citations

Mary Hongying Cheng, Josep Font, Alexandra C. Schwartz, Kaitlyn V. Ledwitch, Amanda M. Duran +14 more

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01353

N/A

0DataRank · unranked

18 citations

Comfort A. Boateng, Francisco O. Battiti, Alessandro Bonifazi, Jianjing Cao, Li Chen +6 more

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

Signal Transduction and Targeted Therapy(2021)10.1038/s41392-021-00630-3

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0DataRank · unranked

14 citations

Kathryn D. Luderman, R. Benjamin Free, Lei Shi, David R. Sibley

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

Biochimie(2021)10.1016/j.biochi.2021.01.007

N/A

0DataRank · unranked

12 citations

Alexander Holenstein, William R. Foster, Bing Xie, Kevin B. Hicks, Céline Bürer +12 more

Regime Shift of Genome Size Crossing the Chasm of Eukaryogenesis

Preprints.org(2021)10.20944/preprints202110.0027.v1

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0DataRank · unranked

1 citations

Xu Zhao, Xu Chi, Yang Liu, Ying Liu, Lei Shi +3 more

Psychomotor Impairments and Therapeutic Implications Revealed by a Mutation Associated with Infantile Parkinsonism-Dystonia

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.09.434693

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0DataRank · unranked

0 citations

Mary Hongying Cheng, Josep Font, Alexandra C. Schwartz, Kaitlyn V. Ledwitch, Amanda M. Duran +14 more

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

ChemRxiv(2021)10.26434/chemrxiv-2021-l1hfw

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0DataRank · unranked

0 citations

Alexander A. Goldberg, Lei Shi, Bing Xie

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

Computational and Structural Biotechnology Journal(2022)10.1016/j.csbj.2022.05.013

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0DataRank · unranked

27 citations

Alexander Goldberg, Lei Shi, Bing Xie

Disentangling autoproteolytic cleavage from tethered agonist–dependent activation of the adhesion receptor ADGRL3

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102594

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0DataRank · unranked

27 citations

Max W. VanDyck, Kuo Hao Lee, Lei Shi, Jonathan A. Javitch, Nicole A. Perry

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists

Molecules(2022)10.3390/molecules27196455

N/A

0DataRank · unranked

11 citations

Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Alexander Goldberg, Bing Xie +9 more

Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00202

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0DataRank · unranked

5 citations

Ashley N. Nilson, Noelia Boldizsar, Trevor Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov +14 more

Editorial: Targeting Membrane Proteins: Structure-Function-Dynamics Relationships

Frontiers in Chemistry(2022)10.3389/fchem.2022.862802

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0DataRank · unranked

0 citations

İvet Bahar, Lei Shi, Josep Font, Claire Colas

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

ChemRxiv(2022)10.26434/chemrxiv-2021-l1hfw-v2

N/A

0DataRank · unranked

0 citations

Alexander Goldberg, Lei Shi, Bing Xie

Identification and Characterization of ML321: a Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.14.516475

N/A

0DataRank · unranked

0 citations

Ashley N. Nilson, Noelia Boldizsar, Trevor Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov +14 more

Alkoxy chain length governs the potency of 2-benzylbenzimidazole ‘nitazene’ opioids associated with human overdose

Psychopharmacology(2023)10.1007/s00213-023-06451-2

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0DataRank · unranked

48 citations

Marthe M. Vandeputte, Li Chen, Donna Walther, Meng-Hua M. Tsai, Lei Shi +3 more

Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide

Drug and Alcohol Dependence(2023)10.1016/j.drugalcdep.2023.109939

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0DataRank · unranked

37 citations

Meng-Hua M. Tsai, Li Chen, Grant C. Glatfelter, Donna Walther, Christophe P. Stove +3 more

Binding preference at the μ-opioid receptor underlies distinct pharmacology of cyclopropyl versus valeryl analogs of fentanyl

Neuropharmacology(2023)10.1016/j.neuropharm.2023.109442

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0DataRank · unranked

19 citations

Valerie P. Le Rouzic, Alexander Goldberg, Meng-Hua M. Tsai, Li Chen, Tiffany Zhang +5 more

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2304089120

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0DataRank · unranked

13 citations

Ara M. Abramyan, Per Plenge, Lingle Wang, Christoffer Bundgaard, Benny Bang‐Andersen +3 more

Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor

ACS Chemical Neuroscience(2023)10.1021/acschemneuro.3c00530

N/A

0DataRank · unranked

12 citations

Rezvan Chitsazi, Christopher Lucaj, Phuong T. Tran, Alexander F. Hoffman, Michael H. Baumann +3 more

Dopamine receptor divergence revealed using a common ligand

Trends in Pharmacological Sciences(2023)10.1016/j.tips.2023.08.002

N/A

0DataRank · unranked

3 citations

Ashley N. Nilson, Amy E. Moritz, Lei Shi, David R. Sibley

A Novel “Activation Switch” Motif Common to All Aminergic Receptors

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00732

N/A

0DataRank · unranked

9 citations

Jamie J. Manning, Jonathan A. Javitch, Lei Shi, Kuo Hao Lee

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c02037

N/A

0DataRank · unranked

8 citations

Gisela Andrea Camacho‐Hernandez, Kristine Salomon, Kuo Hao Lee, Therese Ku, Jianjing Cao +11 more

The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor

International Journal of Molecular Sciences(2023)10.3390/ijms241612848

N/A

0DataRank · unranked

4 citations

Bing Xie, Lei Shi, Alexander Goldberg

Dynamic extracellular vestibule of human SERT: unveiling druggable potential with novel high-affinity allosteric inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-wcjnt

N/A

0DataRank · unranked

1 citations

Ara M. Abramyan, Per Plenge, Lingle Wang, Benny Bang‐Andersen, Claus J. Løland +2 more

A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.10.544442

N/A

0DataRank · unranked

1 citations

Rezvan Chitsazi, Christopher Lucaj, Phuong T. Tran, Alexander F. Hoffman, Michael H. Baumann +3 more

Physiological effects of fentanyl analogs found in recreational drug markets

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.174350

N/A

0DataRank · unranked

0 citations

Shelby A. McGriff, Eric B. Thorndike, Li Chen, Donna Walther, Kenner C. Rice +3 more

Examining the mu-opioid receptor bias of fentanyl and 2-benzylbenzimidazole opioids in clandestine drug markets

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.156170

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0DataRank · unranked

0 citations

Li Chen, Michael H. Baumann, Lei Shi, Meng-Hua M. Tsai

The molecular mechanism of positive allosteric modulation at the dopamine D1 receptor

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.27.550907

N/A

0DataRank · unranked

0 citations

Bing Xie, Lei Shi, Alexander Goldberg

In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.3c00750

N/A

0DataRank · unranked

27 citations

Li Chen, Michael H. Baumann, Meritxell Canals, Jonathan A. Javitch, J. Robert Lane +2 more

Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress

Cellular and Molecular Life Sciences(2024)10.1007/s00018-023-05023-z

N/A

0DataRank · unranked

10 citations

Yuko Yasui, Semnyonga Foncham, Ioannis Grammatikakis, Ashish Lal, Lei Shi +2 more

Linkers in Bitopic Agonists Shape Bias Profile among Transducers for the Dopamine D2 and D3 Receptors

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00119

N/A

0DataRank · unranked

7 citations

Rian Garland, Alessandro Bonifazi, Kuo Hao Lee, John Famiglietti, Wenqi Zhang +6 more

Unraveling Activation-Related Rearrangements and Intrinsic Divergence from Ligand-Specific Conformational Changes of the Dopamine D3 and D2 Receptors

Journal of Chemical Information and Modeling(2024)10.1021/acs.jcim.3c01956

N/A

0DataRank · unranked

3 citations

Lei Shi, Kuo Hao Lee

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

Biomolecules(2024)10.3390/biom14060713

N/A

0DataRank · unranked

1 citations

Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman, Lei Shi, Kuo-Hao Lee

A Putative Binding Model of Nitazene Derivatives at the μ -Opioid Receptor

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.03.616560

N/A

0DataRank · unranked

1 citations

Lei Shi, Michael J. Robertson, Georgios Skiniotis, Michael Michaelides, Lidiya Stavitskaya +2 more

A subtle modification of modafinil-based DAT inhibitors changes conformational preference

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.06.583808

N/A

0DataRank · unranked

0 citations

Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman, Lei Shi, Kuo Hao Lee

A putative binding model of nitazene derivatives at the μ-opioid receptor

Neuropharmacology(2025)10.1016/j.neuropharm.2025.110437

N/A

0DataRank · unranked

11 citations

Lei Shi, Michael J. Robertson, Georgios Skiniotis, Michael Michaelides, Lidiya Stavitskaya +2 more

Locomotor activity depends on β-arrestin recruitment by the dopamine D1 receptor in the striatal D1-D3 receptor heteromer

Pharmacological Research(2025)10.1016/j.phrs.2025.107826

N/A

0DataRank · unranked

5 citations

Marc Ciruela-Jardí, William Rea, Bradley M. Keegan, Marjorie R. Levinstein, Alessandro Bonifazi +13 more

N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108174

N/A

0DataRank · unranked

4 citations

Jonathan R Du Rand, Kuo Hao Lee, Lei Shi, Jonathan A. Javitch, Nicole A. Perry

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Nature Communications(2020)10.1038/s41467-020-15292-y

N/A

0DataRank · unranked

50 citations

Ara M. Abramyan, G. Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether +4 more

Decoding the Structure–Activity Relationship of the Dopamine D3 Receptor-Selective Ligands Using Machine and Deep Learning Approaches

Journal of Chemical Information and Modeling(2025)10.1021/acs.jcim.5c00575

N/A

0DataRank · unranked

1 citations

Benjoe Rey B. Visayas, Kuo Hao Lee, Rey Y. Capangpangan, Lei Shi, Sung Joon Won

ESG‐1‐60 and ESG‐1‐61: Novel dopamine D3 receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

British Journal of Pharmacology(2025)10.1111/bph.70021

N/A

0DataRank · unranked

4 citations

Bradley M. Keegan, Hannah Alton, Guo‐Hua Bi, Emily Linz, Caleb D. Vogt +5 more

Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01585

N/A

0DataRank · unranked

1 citations

Feijun Wang, Nora S. Madaras, Amber M. Kelley, Kirsten K. Snyder, Disha M. Gandhi +8 more

Decoding the Structure-Activity Relationship of the Dopamine D3 Receptor-Selective Ligands Using Machine and Deep Learning Approaches

ChemRxiv(2025)10.26434/chemrxiv-2025-qtp1q

N/A

0DataRank · unranked

0 citations

Benjoe Rey B. Visayas, Kuo Hao Lee, Rey Y. Capangpangan, Lei Shi, Sung Joon Won

Conformational dynamics of the active state of β-arrestin 1

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.10.658911

N/A

0DataRank · unranked

0 citations

Wesley B. Asher, Jonathan A. Javitch, Lei Shi, Van A. Ngo

Membrane Permeability Drives the Extreme Potency of Fentanyl but not Isotonitazene

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.22.666146

N/A

0DataRank · unranked

0 citations

George J. Farmer, Jacqueline R. Glenn, Shailesh N. Mistry, J. Robert Lane, Lei Shi +4 more

Ligand Reorganization for End-Point Binding Free Energy Calculations: Identifying Preferred Poses of Fentanyls in the μ Opioid Receptor

Journal of Chemical Theory and Computation(2025)10.1021/acs.jctc.4c01073

N/A

0DataRank · unranked

4 citations

David A. Cooper, Bing Xie, Lei Shi, David D. L. Minh

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

Science Signaling(2020)10.1126/scisignal.aaw5885

N/A

0DataRank · unranked

47 citations

Ravi Kumar Verma, Blair K. A. Willette, Elizabeth C. Gonye, Annah M. Moore, Amy E. Moritz +6 more

The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor

Computational and Structural Biotechnology Journal(2020)10.1016/j.csbj.2019.12.012

N/A

0DataRank · unranked

17 citations

Hideaki Yano, Ming Xu, Leanne Liu, Sett Naing, Andrew D. Fant +2 more

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00425

N/A

0DataRank · unranked

15 citations

Alessandro Bonifazi, Adrian M. Guerrero, Vivek Kumar, R. Benjamin Free, J. Robert Lane +5 more

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

eLife(2020)10.7554/elife.52189

N/A

0DataRank · unranked

41 citations

Ara M. Abramyan, Pramisha Adhikari, Alastair C. Keen, Kuo‐Hao Lee, Julie Sanchez +6 more

Positive Allosteric Modulation of the 5-HT1A Receptor by Indole-Based Synthetic Cannabinoids Abused by Humans

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00034

N/A

0DataRank · unranked

26 citations

Pramisha Adhikari, Sett Naing, Alexander F. Hoffman, Michael H. Baumann, Carl R. Lupica +2 more