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Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Biomolecules(2021)10.3390/biom11040570Source: DataRank Database

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor is a research paper published in Biomolecules (2021). On theSindex it has a DataRank of 0. It has been cited 23 times.

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Open Access23 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 1.11)OA: goldTopics (67)IDs (PubMed, PMC, OpenAlex)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Bing Xie ORCID,Ana Semeano ORCID,Alessandro Bonifazi ORCID,Francisco O. Battiti ORCID,Amy Hauck Newman ORCID

Live enrichment

PubMed:33924613 PMC:PMC8069330 OpenAlex:https://openalex.org/W3154409679

National Institutes of Health

Grant: Z1A DA000389

National Institutes of Health

Grant: Z1A DA000606

Brain and Behavior Research Foundation

Grant: Young Investigator Award

National Institutes of Health

Grant: 1ZIADA000389-22

Novel and Atypical Dopamine Uptake Inhibitors

FWCI

1.11

Citation Percentile

0.8%

Citation Trend

2012

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/2218-273X/11/4/570/pdf?version=1618394441

publisherhttps://www.mdpi.com/2218-273X/11/4/570/pdf?version=1618394441

publisherhttps://www.mdpi.com/2218-273X/11/4/570/pdf

journalhttps://doi.org/10.3390/biom11040570

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33924613

Fields of Study

Receptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies ResearchChemical Synthesis and Analysis0301 basic medicine03 medical and health sciences0303 health sciencesAminopyridinesBinding SitesDopamine AgonistsEnergy TransferHEK293 CellsHumansLuminescenceMorpholinesProtein BindingReceptors, Dopamine D2Receptors, Dopamine D3StereoisomerismStructure-Activity Relationship

MeSH Terms

AminopyridinesBinding SitesEnergy TransferHumansMorpholinesProtein BindingStereoisomerismStructure-Activity RelationshipReceptors, Dopamine D2Dopamine AgonistsLuminescenceReceptors, Dopamine D3HEK293 Cells

Keywords

PharmacophoreDopamine receptor D3ChemistryAgonistDopamine receptor D2Functional selectivityPharmacologyReceptorG protein-coupled receptorStereochemistryBiologyBiochemistryChiralityDopamine D3 ReceptorDopamine D2 ReceptorSubtype SelectivityBiased AgonismBitopic LigandSubtype AffinityLuminescenceMorpholinesAminopyridinesMicrobiologyStructure-Activity RelationshipHumansBinding SitesReceptors, Dopamine D2Brief ReportReceptors, Dopamine D3StereoisomerismQR1-502HEK293 CellsEnergy TransferDopamine AgonistsProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 10: 10. No inequalitySDG 0: Good health and well-being