David L. Williams

Also affiliated with National Security Agency, Environment Agency, University of Cambridge

Agricultural and Biological SciencesImmunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 43 papers. Top paper: “Trained immunity, tolerance, priming and differentiation: distinct immunological processes”.

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Nature Immunology(2020)10.1038/s41590-020-00845-6

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603 citations

Peter Aaby, Shabaana A. Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis +39 more

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Frontiers in Immunology(2020)10.3389/fimmu.2020.587913

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270 citations

Jingjing Xu, Min Fan, Fei Tu, Xiaohui Wang, Tuanzhu Ha +3 more

β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies

Journal of Clinical Investigation(2020)10.1172/jci134778

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76 citations

Mathieu Bohm, Alícia Corbellini Piffer, Rachel Lavenir, David L. Williams, Bénédicte Neven +4 more

Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis

Frontiers in Immunology(2020)10.3389/fimmu.2020.00825

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59 citations

Xiaohui Wang, Xia Zhang, Tuanzhu Ha, Yana Wang, Min Fan +8 more

Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction

JCI Insight(2020)10.1172/jci.insight.139640

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38 citations

Kun Yang, Xiaohui Wang, Yana Wang, Fei Tu, Tuanzhu Ha +4 more

Using Expanded Natural Killer Cells as Therapy for Invasive Aspergillosis

Journal of Fungi(2020)10.3390/jof6040231

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14 citations

Joan Hui Juan Lim, David L. Williams, Jessamine Geraldine Goh, Zhaohong Tan, Qi Hui Sam +7 more

Cholinergic leukocytes in sepsis and at the neuroimmune junction in the spleen

International Immunopharmacology(2020)10.1016/j.intimp.2020.106359

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22 citations

Megan D. Poston, Stacy D. Brown, Sarah Lawson, Cherie E. Bond, Anthony M. Downs +3 more

Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126

Frontiers in Immunology(2020)10.3389/fimmu.2020.00566

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42 citations

Xiaohui Wang, Min Fan, Fei Tu, Kun Yang, Tuanzhu Ha +5 more

Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Journal of Leukocyte Biology(2020)10.1002/jlb.3ce0720-468

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2 citations

David L. Williams, Edward R. Sherwood

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Cell Death and Differentiation(2021)10.1038/s41418-021-00841-9

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772 citations

Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, Fei Tu +6 more

β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages

The Journal of Immunology(2021)10.4049/jimmunol.2100107

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106 citations

Katherine R. Burelbach, Allison M. Owen, Naeem K. Patil, Margaret A. McBride, Julia K. Bohannon +6 more

Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata

mSphere(2021)10.1128/msphere.00406-21

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72 citations

Chad Johnson, Robert Żarnowski, Brody D. Andes, Taylor J. Schoen, John F. Kernien +7 more

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

npj Biofilms and Microbiomes(2021)10.1038/s41522-021-00257-w

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28 citations

Yasir Almuhanna, Mohammad Y. Alshahrani, Douglas W. Lowman, Peter J. Rice, Chris Gell +18 more

Glucan and glycogen exist as a covalently linked macromolecular complex in the cell wall of Candida albicans and other Candida species

The Cell Surface(2021)10.1016/j.tcsw.2021.100061

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23 citations

M. Sameer Al‐Abdul‐Wahid, Zuchao Ma, Michael Kruppa, Elena Rustchenko, David L. Williams +1 more

Frontline Science: The expression of integrin αDβ2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis

Journal of Leukocyte Biology(2021)10.1002/jlb.3hi0820-529rr

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15 citations

Kui Cui, Christopher L. Ardell, Kasey R. Keever, Sanjay K. Singh, Diego J. Rodriguez‐Gil +4 more

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

JCI Insight(2022)10.1172/jci.insight.158183

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135 citations

Lu Liu, Keman Xu, Ramón Cueto, Ying Shao, Yifan Lu +14 more

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Cell(2022)10.1016/j.cell.2022.01.009

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124 citations

Valentina Poli, Ellen Shrock, Roberto Spreafico, Xin Liu, Novalia Pishesha +29 more

Innate Immune Memory and the Host Response to Infection

The Journal of Immunology(2022)10.4049/jimmunol.2101058

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96 citations

Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Allison M. Owen, Antonio Hernandez +4 more

Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis

Frontiers in Immunology(2022)10.3389/fimmu.2022.872652

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26 citations

Tammy R. Ozment, Nicole Lewis, Edward R. Sherwood, David L. Williams, Parkash S. Gill

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

Frontiers in Immunology(2022)10.3389/fimmu.2022.868679

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19 citations

Matthew T. Holt, Min Fan, Victor L. Lam, Yong Yang, Tuanzhu Ha +4 more

Modification of Extracellular Matrix by the Product of DHA Oxidation Switches Macrophage Adhesion Patterns and Promotes Retention of Macrophages During Chronic Inflammation

Frontiers in Immunology(2022)10.3389/fimmu.2022.867082

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6 citations

Kasey R. Keever, Christopher L. Ardell, David L. Williams, Detao Gao, Eugene A. Podrez +3 more

β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping

Immunology and Cell Biology(2022)10.1111/imcb.12536

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7 citations

Beatrice Volpe, Rory Doolan, Gillian Coakley, Mati Moyat, Julia Esser‐von Bieren +9 more

Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

Science Advances(2023)10.1126/sciadv.adc9465

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382 citations

Kun Yang, Xiaohui Wang, Linjian Chen, Parkash S. Gill, Tuanzhu Ha +5 more

Glycogen Metabolism in Candida albicans Impacts Fitness and Virulence during Vulvovaginal and Invasive Candidiasis

mBio(2023)10.1128/mbio.00046-23

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34 citations

Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael Kruppa +2 more

Bacteria- and fungus-derived PAMPs induce innate immune memory via similar functional, metabolic, and transcriptional adaptations

Journal of Leukocyte Biology(2023)10.1093/jleuko/qiad120

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19 citations

Cody L. Stothers, Benjamin A. Fensterheim, Katherine R Caja, Allison M. Owen, Antonio Hernandez +10 more

Development of Negative Controls for Fc-C-Type Lectin Receptor Probes

Microbiology Spectrum(2023)10.1128/spectrum.01135-23

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3 citations

M. Kay, Fabián Salazar, Daniel P. Conn, David L. Williams, Peter C. Cook +3 more

Lactate’s impact on immune cells in sepsis: unraveling the complex interplay

Frontiers in Immunology(2024)10.3389/fimmu.2024.1483400

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55 citations

Linjian Chen, Gatkek Kueth, E. Shao, Xiaohui Wang, Tuanzhu Ha +5 more

Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation

Journal of Neuroinflammation(2024)10.1186/s12974-023-03001-7

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47 citations

Kui Cui, Jared L. Casteel, Sanjay K. Singh, Donald B. Hoover, David L. Williams +3 more

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

Nature Immunology(2024)10.1038/s41590-024-01830-z

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45 citations

David Alejandro Bejarano, Natalie Katzmarski, Jessica Haub, Jonas Schulte-Schrepping, Jiangyan Yu +27 more

Candida albicans N-Linked Mannans Potentiate the Induction of Trained Immunity via Dectin-2

The Journal of Infectious Diseases(2024)10.1093/infdis/jiae112

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25 citations

Arnab Pradhan, Julia I. P. van Heck, Leonie Helder, Martin Jaeger, Neil A. R. Gow +6 more

Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity

Cell Reports(2024)10.1016/j.celrep.2024.113932

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15 citations

María Moreno, Lisa U. Teufel, Sofía Chilibroste, Samuel T. Keating, Laszlo Groh +11 more

Trained immunity enhances host resistance to infection in aged mice

Journal of Leukocyte Biology(2024)10.1093/jleuko/qiae259

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3 citations

Katherine R Caja, Margaret A. McBride, Allison M. Owen, Julia K. Bohannon, Antonio Hernández +5 more

Self‐recognition through Dectin‐1 exacerbates liver inflammation

Genes to Cells(2024)10.1111/gtc.13106

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4 citations

Douglas W. Lowman, Toshihiko Sugiki, David L. Williams, Sho Yamasaki, Shota Torigoe

Recent advances in chemical synthesis of phosphodiester linkages found in fungal mannans

Carbohydrate Research(2024)10.1016/j.carres.2024.109325

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3 citations

Harry E. Ensley, Douglas W. Lowman, Michael Kruppa, David L. Williams, Zuchao Ma

Synthesis of a unique mannose α-1-phosphate side chain moiety found in Candida auris cell wall mannan

Carbohydrate Research(2024)10.1016/j.carres.2024.109059

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3 citations

Harry E. Ensley, Bridget Graves, Michael Kruppa, Peter J. Rice, Douglas W. Lowman +2 more

Glycogen synthase activity in Candida albicans is partly controlled by the functional ortholog of Saccharomyces cerevisiae Gac1p

mSphere(2024)10.1128/msphere.00575-24

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0 citations

David L. Williams, Michael Kruppa, Brian M. Peters, Jian Miao

Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy

Cardiovascular Research(2025)10.1093/cvr/cvaf158

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9 citations

Junedh Amrute, Attila Kovács, Abhinav Diwan, David L. Williams, Douglas L. Mann +1 more

Metabolic adaptations driving innate immune memory: mechanisms and therapeutic implications

Journal of Leukocyte Biology(2025)10.1093/jleuko/qiaf037

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7 citations

Margaret A. McBride, Julia K. Bohannon, Antonio Hernández, Benjamin Klein, David L. Williams +2 more

In vitro protocol demonstrating five functional steps of trained immunity in mice: Implications on biomarker discovery and translational research

Cell Reports(2025)10.1016/j.celrep.2025.116202

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6 citations

Jana Baranda, Leticia Pérez‐Rodríguez, Patricia Conde, Carlos de la Calle‐Fabregat, Marcos J. Berges-Buxeda +17 more

HSPA12B Protects Against Age‐Related Endothelial Cell Senescence by Regulating STING Degradation

Aging Cell(2025)10.1111/acel.70260

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5 citations

Peilin Zhu, J. S. Adams, Fei Tu, Jialing Wang, Chloe G. Garbe +8 more

Heme drives cardiac endothelial senescence in sepsis via STING activation

Cell Death and Disease(2025)10.1038/s41419-025-08370-w

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3 citations

Peilin Zhu, Jialing Wang, Tao Zhang, J. S. Adams, Fei Tu +8 more

Dectin-1 stimulating β-glucans inhibit Chlamydia infections both in vitro and in vivo

Pathogens and Disease(2025)10.1093/femspd/ftaf002

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2 citations

Morgan Callaghan, Lillith Bulawa, Angela Chu, Zuchao Ma, David L. Williams +4 more

β‐Glucan Protects Against Sepsis‐Induced Kupffer Cell Loss by Inhibiting Pyroptosis and Promoting Self‐Renewal

Immunology(2025)10.1111/imm.70043

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0 citations

Tingting Li, Peilin Zhu, Chloe G. Garbe, Fei Tu, Jared L. Casteel +5 more